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Potassium channel inhibitors induce oxidative stress in breast cancer cells

Çağri Öner

Çağri Öner

Department of Medical Biology, Medical Faculty, Eskişehir Osmangazi UniversityEskişehir, Turkey
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Öner, Çağri
, 
Ertuğrul Çolak

Ertuğrul Çolak

Department of Biostatics and Bioinformatics, Medical Faculty, Eskişehir Osmangazi UniversityEskişehir, Turkey
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Çolak, Ertuğrul
 and 
Didem Turgut Coşan

Didem Turgut Coşan

Department of Medical Biology, Medical Faculty, Eskişehir Osmangazi UniversityEskişehir, Turkey
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Coşan, Didem Turgut
  
Mar 21, 2018
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Article Category: Original article
Published Online: Mar 21, 2018
Page range: 323 - 330
DOI: https://doi.org/10.1515/abm-2018-0004
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© 2017 Çağri Öner, Ertuğrul Çolak, Didem Turgut Coşan
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Figure 1

The effects of voltage-gated potassium channel inhibitors on the total antioxidant, oxidant, and oxidative stress levels of MCF-7 breast cancer cells. (A) The effects of tetraethyl ammonium chloride (TEA), 4-aminopyridine (4-AP), margatoxin (MgTX), or astemizole (AST) on the total antioxidant levels in MCF-7 cells. (B) The effects of TEA, 4-AP, MgTX, or AST on the total oxidant level in MCF-7 cells. (C) The effects of TEA, 4-AP, MgTX, or AST on the oxidative stress level in MCF-7 cells. n = 7 for each experiment group; error bars = 10 standard deviations. ∗P < 0.001
The effects of voltage-gated potassium channel inhibitors on the total antioxidant, oxidant, and oxidative stress levels of MCF-7 breast cancer cells. (A) The effects of tetraethyl ammonium chloride (TEA), 4-aminopyridine (4-AP), margatoxin (MgTX), or astemizole (AST) on the total antioxidant levels in MCF-7 cells. (B) The effects of TEA, 4-AP, MgTX, or AST on the total oxidant level in MCF-7 cells. (C) The effects of TEA, 4-AP, MgTX, or AST on the oxidative stress level in MCF-7 cells. n = 7 for each experiment group; error bars = 10 standard deviations. ∗P < 0.001

Figure 2

The effects of voltage-gated potassium channel inhibitors on the total antioxidant, oxidant and oxidative stress levels of MDA-MB-231 breast cancer cells. (A) The effects of tetraethyl ammonium chloride (TEA), 4-aminopyridine (4-AP), margatoxin (MgTX), and astemizole (AST) on the total antioxidant levels in MDA-MB-231 cells. (B) The effects of TEA, 4-AP, MgTX, and AST on the total oxidant level in MDA-MB-231 cells. (C) The effects of TEA, 4-AP, MgTX, and AST on the oxidative stress level of MDA-MB-231 cells. n = 7 for each experiment group; error bars = 10 standard deviations; ∗P < 0.001
The effects of voltage-gated potassium channel inhibitors on the total antioxidant, oxidant and oxidative stress levels of MDA-MB-231 breast cancer cells. (A) The effects of tetraethyl ammonium chloride (TEA), 4-aminopyridine (4-AP), margatoxin (MgTX), and astemizole (AST) on the total antioxidant levels in MDA-MB-231 cells. (B) The effects of TEA, 4-AP, MgTX, and AST on the total oxidant level in MDA-MB-231 cells. (C) The effects of TEA, 4-AP, MgTX, and AST on the oxidative stress level of MDA-MB-231 cells. n = 7 for each experiment group; error bars = 10 standard deviations; ∗P < 0.001
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