Serum HBV DNA |
>10 · IU/ml |
>2000 IU/ml (constantly raised or fluctuating) |
<2000 IU/mL |
>2000 IU/mL |
undetectable |
ALT |
normal |
elevated |
normal |
elevated |
normal |
HBeAg |
positive |
positive |
negative |
negative |
negative |
HBsAg |
high |
high/intermediate |
low |
intermediate |
negative |
cccDNA |
+++++ |
+++++ |
++ |
+++ |
+ |
Integrated HBV DNA |
+++ |
++++ |
+++ |
++++ |
+ |
Liver disease (Necro-inflammatory changes) |
none/minimal |
moderate to severe |
none |
moderate to severe |
none |
Progression to cirrhosis |
none |
possible |
none |
more rapid than in other phases |
none |
Treatment |
not generally indicated |
may be indicated |
not indicated |
may be indicated |
not indicated |