Serum HBV DNA | >10 · IU/ml | >2000 IU/ml (constantly raised or fluctuating) | <2000 IU/mL | >2000 IU/mL | undetectable |
ALT | normal | elevated | normal | elevated | normal |
HBeAg | positive | positive | negative | negative | negative |
HBsAg | high | high/intermediate | low | intermediate | negative |
cccDNA | +++++ | +++++ | ++ | +++ | + |
Integrated HBV DNA | +++ | ++++ | +++ | ++++ | + |
Liver disease (Necro-inflammatory changes) | none/minimal | moderate to severe | none | moderate to severe | none |
Progression to cirrhosis | none | possible | none | more rapid than in other phases | none |
Treatment | not generally indicated | may be indicated | not indicated | may be indicated | not indicated |