<abstract xmlns="http://www.w3.org/1999/xhtml"><p>In this study, optimal conditions to form cellulose-MgO nanocomposite with antibacterial properties were evaluated. Applying the Taguchi method, 9 experiments were designed and the effects of different concentrations of biopolymers cellulose (0.5, 1 and 2 mg/ml), MgO nanoparticles (2, 4 and 8 mg/ml) and stirring times (30, 60 and 90 min) on antibacterial activity of synthesized nanocomposites were assessed. The characterizations of products were investigated by dynamic light scattering (DLS), raman spectroscopy, scanning electron microscope (SEM), thermogravimetric analysis (TGA) and differential thermal analysis (DTA). The results showed that the nano-composite produced in the conditions of experiment 9 (MgO 8 mg/ml, cellulose 2 mg/ml and stirring time of 60 min) has the strongest antibacterial activity. The outcomes of both methods of colony forming units (CFU) and disc diffusion indicated that the antibacterial activity of cellulose-MgO nanocomposite was significantly higher than its components (P &lt;0.05). Thermal analysis indicated improvement in the thermal stability of the cellulose biopolymer after the formation of the nanocomposite. Due to the improvement of the antibacterial properties of cellulose-MgO nanocomposite compared to its components, we can use it as a new antibacterial agent in the fields of pharmaceutical, medicine and dentistry.</p></abstract>

In this study, optimal conditions to form cellulose-MgO nanocomposite with antibacterial properties were evaluated. Applying the Taguchi method, 9 experiments were designed and the effects of different concentrations of biopolymers cellulose (0.5, 1 and 2 mg/ml), MgO nanoparticles (2, 4 and 8 mg/ml) and stirring times (30, 60 and 90 min) on antibacterial activity of synthesized nanocomposites were assessed. The characterizations of products were investigated by dynamic light scattering (DLS), raman spectroscopy, scanning electron microscope (SEM), thermogravimetric analysis (TGA) and differential thermal analysis (DTA). The results showed that the nano-composite produced in the conditions of experiment 9 (MgO 8 mg/ml, cellulose 2 mg/ml and stirring time of 60 min) has the strongest antibacterial activity. The outcomes of both methods of colony forming units (CFU) and disc diffusion indicated that the antibacterial activity of cellulose-MgO nanocomposite was significantly higher than its components (P <0.05). Thermal analysis indicated improvement in the thermal stability of the cellulose biopolymer after the formation of the nanocomposite. Due to the improvement of the antibacterial properties of cellulose-MgO nanocomposite compared to its components, we can use it as a new antibacterial agent in the fields of pharmaceutical, medicine and dentistry.

Application of Taguchi method in the optimization of synthesis of cellulose-MgO bionanocomposite as antibacterial agent

Advanced Dental Sciences Research Laboratory

Kermanshah University of Medical Sciences

Department of Nanobiotechnology, Faculty of Science

Department of Prosthodontics, School of Dentistry

Department of Oral and Maxillofacial Surgery, School of Dentistry

Polish Journal of Chemical Technology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

In this study, optimal conditions to form cellulose-MgO nanocomposite with antibacterial properties were evaluated. Applying the Taguchi method, 9 experiments...

Application of Taguchi method in the optimization of synthesis of cellulose-MgO bionanocomposite as antibacterial agent

Data publikacji: 31 gru 2019

Zakres stron: 116 - 122

DOI: https://doi.org/10.2478/pjct-2019-0047

Słowa kluczowe
cellulose biopolymer, magnesium oxide nanoparticles, nanocomposite, antibacterial activity, Taguchi method

© 2019 Mohsen Safaei et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Application of Taguchi method in the optimization of synthesis of cellulose-MgO bionanocomposite as antibacterial agent

Data publikacji: 31 gru 2019

Zakres stron: 116 - 122

DOI: https://doi.org/10.2478/pjct-2019-0047

Słowa kluczowecellulose biopolymer, magnesium oxide nanoparticles, nanocomposite, antibacterial activity, Taguchi method

© 2019 Mohsen Safaei et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Słowa kluczowe
cellulose biopolymer, magnesium oxide nanoparticles, nanocomposite, antibacterial activity, Taguchi method