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Resveratrol and prednisolone loaded into human serum albumin nanoparticles for the alleviation of rheumatoid arthritis symptoms: an in vitro and in vivo study

Yongcai Song
Yongcai Song
, 
Yujia Su
Yujia Su
, 
Shaik Althaf Hussain
Shaik Althaf Hussain
 oraz 
Cuiping Tang
Cuiping Tang
   | 28 cze 2024
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Data publikacji: 28 cze 2024
Zakres stron: 16 - 25
Otrzymano: 15 gru 2023
Przyjęty: 24 kwi 2024
DOI: https://doi.org/10.2478/msp-2024-0005
Słowa kluczowe
© 2024 Yongcai Song et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1.

SEM images of (A) RESALNPs, (B) PREALNPs, and (C) drug-free ALNPs. Right panel shows the size distribution of each nanocarrier
SEM images of (A) RESALNPs, (B) PREALNPs, and (C) drug-free ALNPs. Right panel shows the size distribution of each nanocarrier

Fig. 2.

MTT assay with MG-63 cells cultured with RESALNPs, PREALNPs, and ALNPs during 7-day culture. * shows p-value < 0.05
MTT assay with MG-63 cells cultured with RESALNPs, PREALNPs, and ALNPs during 7-day culture. * shows p-value < 0.05

Fig. 3.

Anti-inflammatory assay results with RESAL-NPs and PREALNPs compared with ALNPs and cells cultured with the normal media as the control group, * shows p-value < 0.05
Anti-inflammatory assay results with RESAL-NPs and PREALNPs compared with ALNPs and cells cultured with the normal media as the control group, * shows p-value < 0.05

Fig. 4.

Release of resveratrol and prednisolone from ALNPs during the course of 14 days in PBS
Release of resveratrol and prednisolone from ALNPs during the course of 14 days in PBS

Fig. 5.

Hematoxylin and Eosin (H&E) and Masson’s trichrome staining images of cartilage tissue in different groups
Hematoxylin and Eosin (H&E) and Masson’s trichrome staining images of cartilage tissue in different groups

Fig. 6.

Tissue concentrations of TNF-α, TGF-β, and IL-6 in cartilage tissue treated with different nanocarriers, * shows p-value < 0.05
Tissue concentrations of TNF-α, TGF-β, and IL-6 in cartilage tissue treated with different nanocarriers, * shows p-value < 0.05

DLS assessment results

Sample name Hydrodynamic size Zeta potential
RESALNPs 504.067 ± 30.38 nm −26.05 ± 6.60 mV
PREALNPs 499.91 ± 55.68 nm −24.93 ± 9.94 mV
ALNPs 536.90 ± 42.30 nm −26.33 ± 3.21 mV
eISSN:
2083-134X
Język:
Angielski
Częstotliwość wydawania:
4 razy w roku
Dziedziny czasopisma:
Materials Sciences, other, Nanomaterials, Functional and Smart Materials, Materials Characterization and Properties
Kanał RSS czasopisma