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Materials Science-Poland
Volume 42 (2024): Issue 2 (June 2024)
Open Access
Resveratrol and prednisolone loaded into human serum albumin nanoparticles for the alleviation of rheumatoid arthritis symptoms: an in vitro and in vivo study
Yongcai Song
Yongcai Song
,
Yujia Su
Yujia Su
,
Shaik Althaf Hussain
Shaik Althaf Hussain
and
Cuiping Tang
Cuiping Tang
| Jun 28, 2024
Materials Science-Poland
Volume 42 (2024): Issue 2 (June 2024)
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Published Online:
Jun 28, 2024
Page range:
16 - 25
Received:
Dec 15, 2023
Accepted:
Apr 24, 2024
DOI:
https://doi.org/10.2478/msp-2024-0005
Keywords
resveratrol
,
prednisolone
,
rheumatoid arthritis
,
albumin nanoparticles
© 2024 Yongcai Song et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Fig. 1.
SEM images of (A) RESALNPs, (B) PREALNPs, and (C) drug-free ALNPs. Right panel shows the size distribution of each nanocarrier
Fig. 2.
MTT assay with MG-63 cells cultured with RESALNPs, PREALNPs, and ALNPs during 7-day culture. * shows p-value < 0.05
Fig. 3.
Anti-inflammatory assay results with RESAL-NPs and PREALNPs compared with ALNPs and cells cultured with the normal media as the control group, * shows p-value < 0.05
Fig. 4.
Release of resveratrol and prednisolone from ALNPs during the course of 14 days in PBS
Fig. 5.
Hematoxylin and Eosin (H&E) and Masson’s trichrome staining images of cartilage tissue in different groups
Fig. 6.
Tissue concentrations of TNF-α, TGF-β, and IL-6 in cartilage tissue treated with different nanocarriers, * shows p-value < 0.05
DLS assessment results
Sample name
Hydrodynamic size
Zeta potential
RESALNPs
504.067 ± 30.38 nm
−26.05 ± 6.60 mV
PREALNPs
499.91 ± 55.68 nm
−24.93 ± 9.94 mV
ALNPs
536.90 ± 42.30 nm
−26.33 ± 3.21 mV