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Antibody response to 1.0 and 0.5 mL doses of an inactivated bacterial vaccine against bovine respiratory disease in young Holstein calves: a field trial

Kazusa Mori
Kazusa Mori
, 
Toshihide Kato
Toshihide Kato
, 
Keigo Kosenda
Keigo Kosenda
, 
Osamu Yokota
Osamu Yokota
 oraz 
Hiromichi Ohtsuka
Hiromichi Ohtsuka
   | 20 wrz 2023
Journal of Veterinary Research's Cover Image
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Data publikacji: 20 wrz 2023
Zakres stron: 315 - 321
Otrzymano: 31 sty 2023
Przyjęty: 19 cze 2023
DOI: https://doi.org/10.2478/jvetres-2023-0037
Słowa kluczowe
© 2023 Kazusa Mori et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig. 1.

Antibody responses in young Holstein calves vaccinated with a dose of 1.0 mL or 0.5 mL of an inactivated bacterial vaccine against bovine respiratory disease PV-Control - primary-vaccination control; NV-Control - no-vaccination control; arrows – vaccination times; **, * – significant increase compared to titre at one week of age (P < 0.01, P < 0.05); †† – significant decrease compared to titre at one week of age (P < 0.01); A-B, X-Y, a-b, x-y, α-β, χ-ψ – differences in final antibody titres (P < 0.01, P < 0.01, P < 0.05, P < 0.05, P < 0.10, and P < 0.10, respectively)
Antibody responses in young Holstein calves vaccinated with a dose of 1.0 mL or 0.5 mL of an inactivated bacterial vaccine against bovine respiratory disease PV-Control - primary-vaccination control; NV-Control - no-vaccination control; arrows – vaccination times; **, * – significant increase compared to titre at one week of age (P < 0.01, P < 0.05); †† – significant decrease compared to titre at one week of age (P < 0.01); A-B, X-Y, a-b, x-y, α-β, χ-ψ – differences in final antibody titres (P < 0.01, P < 0.01, P < 0.05, P < 0.05, P < 0.10, and P < 0.10, respectively)

Fig. 2.

Standardised regression coefficients from the logistic regression for seropositivity Primary – primary vaccination; Booster – booster vaccination; * – P < 0.05
Standardised regression coefficients from the logistic regression for seropositivity Primary – primary vaccination; Booster – booster vaccination; * – P < 0.05

Body mass index (BMI) values for the experimental and control groups of young Holstein calves and null hypothesis validity of the values

Group BMI P-value
1.0 + 1.0 0.5 + 1.0 0.5 + 0.5 PV-Control NV-Control
1.0 + 1.0 64.9 ± 0.8 1 0.898 1.000 0.731 0.715
0.5 + 1.0 64.0 ± 0.9 0.898 1 0.975 0.568 0.534
0.5 + 0.5 64.6 ± 0.8 1.000 0.975 1 0.731 0.584
PV-Control 66.8 ± 1.5 0.731 0.568 0.731 1 0.999
NV-Control 66.8 ± 1.7 0.715 0.534 0.584 0.999 1

The number of calves with high and low maternal antibody levels and with positive and negative vaccine responses to (a) H. somni, (b) P. multocida and (c) M. haemolytica

(a) One week of age Seven weeks of age
H. somni High MAL Low MAL P-value Positive Negative P-value
1.0 + 1.0 0 14 − 11 3 0.005**
0.5 + 1.0 0 14 − 12 2 0.000**
0.5 + 0.5 0 14 − 5 9 0.556
PV-Control 0 12 − 1 11 0.008**
NV-Control 0 12 − 0 12 0.000**
P-value 1.000 0.000**
(b) One week of age Seven weeks of age
P. multocida High MAL Low MAL P-value Positive Negative P-value
1.0 + 1.0 9 5 − 14 0 0.015*
0.5 + 1.0 4 10 − 14 0 0.015*
0.5 + 0.5 6 8 − 13 1 0.159
PV-Control 7 5 − 5 7 0.006**
NV-Control 6 6 − 4 8 0.000**
P-value 0.402 0.000**
(c) One week of age Seven weeks of age
M. haemolytica High MAL Low MAL P-value Positive Negative P-value
1.0 + 1.0 9 5 − 2 12 −
0.5 + 1.0 6 8 − 3 11 −
0.5 + 0.5 12 2 − 2 12 −
PV-Control 5 7 − 0 12 −
NV-Control 6 6 − 0 12 −
P-value 0.104 0.275

Dosages of the vaccine and sample size

Group Dose at one week of age Dose at four weeks of age Sample size
1.0 + 1.0 1.0 mL 1.0 mL n = 14
0.5 + 1.0 0.5 mL 1.0 mL n = 14
0.5 + 0.5 0.5 mL 0.5 mL n = 14
PV-Control Not vaccinated 1.0 mL n = 12
NV-Control Not vaccinated Not vaccinated n = 12
eISSN:
2450-8608
Język:
Angielski
Częstotliwość wydawania:
4 razy w roku
Dziedziny czasopisma:
Life Sciences, Molecular Biology, Microbiology and Virology, other, Medicine, Veterinary Medicine
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