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Antibody response to 1.0 and 0.5 mL doses of an inactivated bacterial vaccine against bovine respiratory disease in young Holstein calves: a field trial

Kazusa Mori

Kazusa Mori

Animal Medical Center, Rakuno Gakuen UniversityEbetsu, Hokkaido, Japan
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Mori, Kazusa
, 
Toshihide Kato

Toshihide Kato

Animal Medical Center, Rakuno Gakuen UniversityEbetsu, Hokkaido, Japan
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Kato, Toshihide
, 
Keigo Kosenda

Keigo Kosenda

Animal Medical Center, Rakuno Gakuen UniversityEbetsu, Hokkaido, Japan
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Kosenda, Keigo
, 
Osamu Yokota

Osamu Yokota

F. SIDE Veterinary ServiceSapporo, Hokkaido, Japan
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Yokota, Osamu
 and 
Hiromichi Ohtsuka

Hiromichi Ohtsuka

  • Animal Medical Center, Rakuno Gakuen UniversityEbetsu, Hokkaido, Japan
  • Schools of Agriculture and Animal Science, Obihiro University of Agriculture and Veterinary MedicineObihiro, Hokkaido, Japan
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Ohtsuka, Hiromichi
  
Sep 20, 2023
Antibody response to 1.0 and 0.5 mL doses of an inactivated bacterial vaccine against bovine respiratory disease in young Holstein calves: a field trial's Cover Image
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Published Online: Sep 20, 2023
Page range: 315 - 321
Received: Jan 31, 2023
Accepted: Jun 19, 2023
DOI: https://doi.org/10.2478/jvetres-2023-0037
Keywords
© 2023 Kazusa Mori et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig. 1.

Antibody responses in young Holstein calves vaccinated with a dose of 1.0 mL or 0.5 mL of an inactivated bacterial vaccine against bovine respiratory disease PV-Control - primary-vaccination control; NV-Control - no-vaccination control; arrows – vaccination times; **, * – significant increase compared to titre at one week of age (P < 0.01, P < 0.05); †† – significant decrease compared to titre at one week of age (P < 0.01); A-B, X-Y, a-b, x-y, α-β, χ-ψ – differences in final antibody titres (P < 0.01, P < 0.01, P < 0.05, P < 0.05, P < 0.10, and P < 0.10, respectively)
Antibody responses in young Holstein calves vaccinated with a dose of 1.0 mL or 0.5 mL of an inactivated bacterial vaccine against bovine respiratory disease PV-Control - primary-vaccination control; NV-Control - no-vaccination control; arrows – vaccination times; **, * – significant increase compared to titre at one week of age (P < 0.01, P < 0.05); †† – significant decrease compared to titre at one week of age (P < 0.01); A-B, X-Y, a-b, x-y, α-β, χ-ψ – differences in final antibody titres (P < 0.01, P < 0.01, P < 0.05, P < 0.05, P < 0.10, and P < 0.10, respectively)

Fig. 2.

Standardised regression coefficients from the logistic regression for seropositivity Primary – primary vaccination; Booster – booster vaccination; * – P < 0.05
Standardised regression coefficients from the logistic regression for seropositivity Primary – primary vaccination; Booster – booster vaccination; * – P < 0.05

Body mass index (BMI) values for the experimental and control groups of young Holstein calves and null hypothesis validity of the values

Group BMI P-value
1.0 + 1.0 0.5 + 1.0 0.5 + 0.5 PV-Control NV-Control
1.0 + 1.0 64.9 ± 0.8 1 0.898 1.000 0.731 0.715
0.5 + 1.0 64.0 ± 0.9 0.898 1 0.975 0.568 0.534
0.5 + 0.5 64.6 ± 0.8 1.000 0.975 1 0.731 0.584
PV-Control 66.8 ± 1.5 0.731 0.568 0.731 1 0.999
NV-Control 66.8 ± 1.7 0.715 0.534 0.584 0.999 1

The number of calves with high and low maternal antibody levels and with positive and negative vaccine responses to (a) H_ somni, (b) P_ multocida and (c) M_ haemolytica

(a) One week of age Seven weeks of age
H. somni High MAL Low MAL P-value Positive Negative P-value
1.0 + 1.0 0 14 − 11 3 0.005**
0.5 + 1.0 0 14 − 12 2 0.000**
0.5 + 0.5 0 14 − 5 9 0.556
PV-Control 0 12 − 1 11 0.008**
NV-Control 0 12 − 0 12 0.000**
P-value 1.000 0.000**
(b) One week of age Seven weeks of age
P. multocida High MAL Low MAL P-value Positive Negative P-value
1.0 + 1.0 9 5 − 14 0 0.015*
0.5 + 1.0 4 10 − 14 0 0.015*
0.5 + 0.5 6 8 − 13 1 0.159
PV-Control 7 5 − 5 7 0.006**
NV-Control 6 6 − 4 8 0.000**
P-value 0.402 0.000**
(c) One week of age Seven weeks of age
M. haemolytica High MAL Low MAL P-value Positive Negative P-value
1.0 + 1.0 9 5 − 2 12 −
0.5 + 1.0 6 8 − 3 11 −
0.5 + 0.5 12 2 − 2 12 −
PV-Control 5 7 − 0 12 −
NV-Control 6 6 − 0 12 −
P-value 0.104 0.275

Dosages of the vaccine and sample size

Group Dose at one week of age Dose at four weeks of age Sample size
1.0 + 1.0 1.0 mL 1.0 mL n = 14
0.5 + 1.0 0.5 mL 1.0 mL n = 14
0.5 + 0.5 0.5 mL 0.5 mL n = 14
PV-Control Not vaccinated 1.0 mL n = 12
NV-Control Not vaccinated Not vaccinated n = 12
Language:
English
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Journal Subjects:
Life Sciences, Molecular Biology, Microbiology and Virology, Life Sciences, other, Medicine, Veterinary Medicine
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