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Field trial of antibody response to inactivated bacterial vaccine in young Holstein calves: influence of animal health status

Kazusa Mori
Kazusa Mori
, 
Konosuke Otomaru
Konosuke Otomaru
, 
Toshihide Kato
Toshihide Kato
, 
Osamu Yokota
Osamu Yokota
 oraz 
Hiromichi Ohtsuka
Hiromichi Ohtsuka
   | 25 mar 2022
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Data publikacji: 25 mar 2022
Zakres stron: 109 - 116
Otrzymano: 04 lip 2021
Przyjęty: 11 sty 2022
DOI: https://doi.org/10.2478/jvetres-2022-0003
Słowa kluczowe
© 2022 K. Mori et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig. 1

BMI of the positive and negative group calves at the primary and booster immunisation in the first experiment. * – P < 0.05; ** – P < 0.01; # – P = 0.062
BMI of the positive and negative group calves at the primary and booster immunisation in the first experiment. * – P < 0.05; ** – P < 0.01; # – P = 0.062

Fig. 2

Relationship between body mass index at primary immunisation and maternal antibody titre against Histophilus somni at primary immunisation; post-immunisation titre and maternal antibody titre at primary immunisation against H. somni; post-immunisation titre against H. somni and body mass index at primary immunisation; and post-immunisation titre against H. somni and body mass index at booster vaccination in the first experiment (1) and between maternal antibody titre and serum total protein or gamma globulin at the primary immunisation in the second experiment (2). ** – P < 0.01; # – P < 0.10
Relationship between body mass index at primary immunisation and maternal antibody titre against Histophilus somni at primary immunisation; post-immunisation titre and maternal antibody titre at primary immunisation against H. somni; post-immunisation titre against H. somni and body mass index at primary immunisation; and post-immunisation titre against H. somni and body mass index at booster vaccination in the first experiment (1) and between maternal antibody titre and serum total protein or gamma globulin at the primary immunisation in the second experiment (2). ** – P < 0.01; # – P < 0.10

The number of positive and negative calves following immunisation (a) in each experiment and (b) for each MAL in the first experiment

(a) Experiment Antibody titre BMI Nutritional status Oxidative stress Positive Negative
First ✓ ✓ 77 30
H. somni Second ✓ ✓ ✓ 41 25
Third ✓ ✓ ✓ ✓ 25 22
First ✓ ✓ 101 6
P. multocida Second ✓ ✓ ✓ 61 5
Third ✓ ✓ ✓ ✓ 42 5
First ✓ ✓ 37 70
M. haemolytica Second ✓ ✓ ✓ 8 58
Third ✓ ✓ ✓ ✓ 8 39
(b) MAL Positive Negative P value
50 38 4
100 45 1
P. multocida 200 15 1 -
400 3 0
50 3 16 0.058
100 9 28 0.105
M. haemolytica** 200 12 19 0.566
400 11 7 0.009**
800 2 0 0.050*

Pearson’s correlation analysis

First experiment Maternal antibody titre
 Body mass index
 Post-immunisation titre
H. P. M. At At H. P. M.
somni multocida haemolytica primary booster somni multocida haemolytica
Maternal antibody titre H. somni -
P. multocida 0.530** -
M. haemolytica 0.438** 0.492** -
At primary 0.182 0.048 0.198* -
Body mass index At booster 0.362** 0.298** 0.208* 0.446** -
H. somni 0.132 0.152 0.142 0.316** 0.383** -
Post-immunisation P. multocida −0.033 0.132 0.085 0.370** 0.347** 0.452** -
titre M. haemolytica 0.061 0.227* 0.264** 0.389** 0.278** 0.357** 0.510** -

The nutritional status in the second experiment (a) and oxidative stress marker values in the third experiment (b)

(a) H. somni
 P. multocida
 M.haemolytica
Positive Negative Positive Negative Positive Negative
Total cholesterol P 93.6 ± 5.3 98.5 ± 5.1 96.1 ± 4.0 88.2 ± 13.4 79.3 ± 8.3 97.7 ± 4.1
(mg/dL) B 118.3 ± 5.2 118.6 ± 4.6 118.7 ± 3.8 114.4 ± 12.8 113.8 ± 10.0 119.0 ± 3.9
Blood urea nitrogen P 12.1 ± 0.7 10.9 ± 0.4 11.7 ± 0.5 10.4 ± 0.6 13.3 ± 2.3 11.4 ± 0.5
(mg/dL) B 9.3 ± 0.3 10.4 ± 0.4 9.6 ± 0.2 11.4 ± 0.4 9.3 ± 0.6 9.8 ± 0.2
Total protein P 5.8 ± 0.1* 5.6 ± 0.1 5.7 ± 0.1 5.5 ± 0.2 6.0 ± 0.2 5.7 ± 0.1
(g/dL) B 6.0 ± 0.1 5.9 ± 0.1 6.0 ± 0.0 6.1 ± 0.2 6.0 ± 0.1 6.0 ± 0.0
Albumin/globulin P 1.04 ± 0.03 1.08 ± 0.04 1.05 ± 0.03 1.11 ± 0.10 0.91 ± 0.08* 1.08 ± 0.02
ratio B 1.15 ± 0.03 1.17 ± 0.03 1.16 ± 0.02 1.14 ± 0.08 1.07 ± 0.03 1.17 ± 0.02
Albumin P 2.90 ± 0.04 2.87 ± 0.05 2.89 ± 0.03 2.87 ± 0.10 2.76 ± 0.08 2.91 ± 0.04
(g/dL) B 3.19 ± 0.03 3.16 ± 0.04 3.18 ± 0.03 3.25 ± 0.09 3.11 ± 0.06 3.19 ± 0.03
Alpha globulin P 1.06 ± 0.02 1.07 ± 0.03 1.06 ± 0.02 1.11 ± 0.07 1.15 ± 0.08 1.06 ± 0.02
(g/dL) B 0.97 ± 0.02 0.99 ± 0.02 0.97 ± 0.02 1.04 ± 0.05 0.99 ± 0.03 0.97 ± 0.02
Beta globulin P 1.00 ± 0.03 0.99 ± 0.03 1.00 ± 0.02 0.91 ± 0.06 1.05 ± 0.07 0.99 ± 0.02
(g/dL) B 1.01 ± 0.02 1.01 ± 0.02 1.01 ± 0.01 1.04 ± 0.05 1.01 ± 0.05 1.01 ± 0.01
Gamma globulin P 0.81 ± 0.05* 0.65 ± 0.06 0.76 ± 0.04 0.63 ± 0.12 0.98 ± 0.15* 0.72 ± 0.04
(g/dL) B 0.83 ± 0.03* 0.75 ± 0.04 0.80 ± 0.03 0.79 ± 0.07 0.92 ± 0.09 0.78 ± 0.03
eISSN:
2450-8608
Język:
Angielski
Częstotliwość wydawania:
4 razy w roku
Dziedziny czasopisma:
Life Sciences, Molecular Biology, Microbiology and Virology, other, Medicine, Veterinary Medicine
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