Echinacea purpurea extract (cichoric acid) exerts an anti-inflammatory effect on yak PBMCs and regulates the TLR4 signalling pathway

1Alzaid F., Lagadec F., Albuquerque M, Ballaire R., Orliaguet L., Hainault I., Blugeon C., Lemoine S., Lehuen A., Saliba D.G., Udalova I.A., Paradis V., Foufelle F., Venteclef N.: IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans. JCI Insight 2016, 1, e88689. Alzaid F. Lagadec F. Albuquerque M Ballaire R. Orliaguet L. Hainault I. Blugeon C. Lemoine S. Lehuen A. Saliba D.G. Udalova I.A. Paradis V. Foufelle F. Venteclef N. IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans JCI Insight 2016 1 e8868910.1172/jci.insight.88689Search in Google Scholar

2Barrett B.: Medicinal properties of Echinacea: A critical review. Phytomedicine 2003, 10, 66–86. Barrett B. Medicinal properties of Echinacea: A critical review Phytomedicine 2003 10 66 8610.1078/094471103321648692Search in Google Scholar

3Bhattacharjya S.: De novo designed lipopolysaccharide binding peptides: structure based development of antiendotoxic and antimicrobial drugs. Curr Med Chem 2010, 17, 3080–3093. Bhattacharjya S. De novo designed lipopolysaccharide binding peptides: structure based development of antiendotoxic and antimicrobial drugs Curr Med Chem 2010 17 3080 309310.2174/092986710791959756Search in Google Scholar

4Bukovský M., Vaverková S., Kost'álová D.: Immunomodulating activity of Echinacea gloriosa L, Echinacea angustifolia DC. and Rudbeckia speciosa Wenderoth ethanol-water extracts. Pol J Pharmacol 1995, 47:175–177. Bukovský M. Vaverková S. Kost'álová D. Immunomodulating activity of Echinacea gloriosa L, Echinacea angustifolia DC and Rudbeckia speciosa Wenderoth ethanol-water extracts. Pol J Pharmacol 1995 47175 177Search in Google Scholar

5Chung J.Y., Park Y.C., Ye H., Wu H.: All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction. J Cell Sci 2002, 115, 679–688. Chung J.Y. Park Y.C. Ye H. Wu H. All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction J Cell Sci 2002 115 679 68810.1242/jcs.115.4.679Search in Google Scholar

6Foster C.D., Varghese L.S., Gonzales L.W., Margulies S.S., Guttentag S.H.: The Rho pathway mediates transition to an alveolar type I cell phenotype during static stretch of alveolar type II cells. Pediatr Res 2010, 67, 585–90. Foster C.D. Varghese L.S. Gonzales L.W. Margulies S.S. Guttentag S.H. The Rho pathway mediates transition to an alveolar type I cell phenotype during static stretch of alveolar type II cells Pediatr Res 2010 67 585 9010.1203/PDR.0b013e3181dbc708Search in Google Scholar

7François G., Lionel A., Antoine T., Laetitia A., Yuting M., Carla O., Karim V., Theocharis P., Grégoire M., Evelyn U., Jean-Luc P., Frédéric S., Ezgi T., Martin U., Pierre G., Ahmet C., Bernhard R., Jean K., Jürg T., Fabrice A., Rosette L., Nicole M.M., Nicole M.H., Mark J.S., Guido K., Laurence Z.: Activation of the NLRP3 inflammasome in dendritic cells induces IL-1 beta-dependent adaptive immunity against tumors. Nat Med 2009, 15, 1170–1178. François G. Lionel A. Antoine T. Laetitia A. Yuting M. Carla O. Karim V. Theocharis P. Grégoire M. Evelyn U. Jean-Luc P. Frédéric S. Ezgi T. Martin U. Pierre G. Ahmet C. Bernhard R. Jean K. Jürg T. Fabrice A. Rosette L. Nicole M.M. Nicole M.H. Mark J.S. Guido K. Laurence Z. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1 beta-dependent adaptive immunity against tumors Nat Med 2009 15 1170 117810.1038/nm.2028Search in Google Scholar

8Holger W., William J.H., Wendy S., Shyun L, Zhao D.C.: MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex. Immunity 1997, 7, 837–847. Holger W. William J.H. Wendy S. Shyun L Zhao D.C. MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex Immunity 1997 7 837 84710.1016/S1074-7613(00)80402-1Search in Google Scholar

9Ibeagha-Awemu E.M., Lee J.W., Ibeagha A.E., Bannerman D.D., Paape M.J., Zhao X.: Bacterial lipopolysaccharide induces increased expression of toll-like receptor (TLR) 4 and downstream TLR signaling molecules in bovine mammary epithelial cells. Vet Res 2008, 39, 11. Ibeagha-Awemu E.M. Lee J.W. Ibeagha A.E. Bannerman D.D. Paape M.J. Zhao X. Bacterial lipopolysaccharide induces increased expression of toll-like receptor (TLR) 4 and downstream TLR signaling molecules in bovine mammary epithelial cells Vet Res 2008 39 1110.1051/vetres:2007047Search in Google Scholar

10Kamyar K.Z., Ikizler T.A., Gladys B., Morrel M. A., Joel D. K.: Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences. Am J Kidney Dis 2003, 42, 864–881. Kamyar K.Z. Ikizler T.A. Gladys B. Morrel M. A. Joel D. K. Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences Am J Kidney Dis 2003 42 864 88110.1016/j.ajkd.2003.07.01614582032Search in Google Scholar

11Kanwal Z., Wiegertjes G.F., Veneman W.J., Meijer A.H., Spaink H.P.: Comparative studies of Toll-like receptor signalling using zebrafish. Dev Comp Immunol 2014, 46, 35–52. Kanwal Z. Wiegertjes G.F. Veneman W.J. Meijer A.H. Spaink H.P. Comparative studies of Toll-like receptor signalling using zebrafish Dev Comp Immunol 2014 46 35 5210.1016/j.dci.2014.02.00324560981Search in Google Scholar

12Kawai T., Akira S.: Signaling to NF-κB by Toll-like receptors. Trends Mol Med 2007, 13, 460–469. Kawai T. Akira S. Signaling to NF-κB by Toll-like receptors Trends Mol Med 2007 13 460 46910.1016/j.molmed.2007.09.00218029230Search in Google Scholar

13Kim H.R., Oh S.K., Lim W., Lee H.K., Moon B., Seoh J.Y.: Immune enhancing effects of Echinacea purpurea root extract by reducing regulatory T cell number and function. Nat Prod Commun 2014, 9, 511–514. Kim H.R. Oh S.K. Lim W. Lee H.K. Moon B. Seoh J.Y. Immune enhancing effects of Echinacea purpurea root extract by reducing regulatory T cell number and function Nat Prod Commun 2014 9 511 51410.1177/1934578X1400900422Search in Google Scholar

14Kim K.M., Heo D.R., Kim Y.A., Lee J., Kim N.S., Bang O.S.: Coniferaldehyde inhibits LPS-induced apoptosis through the PKC alpha/beta Ⅱ/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Environ Toxicol Pharmacol 2016, 48, 85–93. Kim K.M. Heo D.R. Kim Y.A. Lee J. Kim N.S. Bang O.S. Coniferaldehyde inhibits LPS-induced apoptosis through the PKC alpha/beta Ⅱ/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells Environ Toxicol Pharmacol 2016 48 85 9310.1016/j.etap.2016.10.01627770660Search in Google Scholar

15Krausgruber T., Blazek K., Smallie T., Alzabin S., Lockstone H., Sahgal N., Hussell T., Feldmann M., Udalova I.A.: IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat Immunol 2011, 12, 231–238. Krausgruber T. Blazek K. Smallie T. Alzabin S. Lockstone H. Sahgal N. Hussell T. Feldmann M. Udalova I.A. IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses Nat Immunol 2011 12 231 23810.1038/ni.199021240265Search in Google Scholar

16Medzhitov R.: Recognition of microorganisms and activation of the immune response. Nature 2007, 449, 819–826. Medzhitov R. Recognition of microorganisms and activation of the immune response Nature 2007 449 819 82610.1038/nature0624617943118Search in Google Scholar

17Pellati F., Epifano F., Contaldo N., Orlandini G., Cavicchi L., Genovese S., Bertelli D. Benvenuti S., Curini M., Bertaccini A., Bellardi M.G.: Chromatographic methods for metabolite profiling of virus- and phytoplasma-infected plants of Echinacea purpurea. J Agric Food Chem 2011, 59, 10425–10434. Pellati F. Epifano F. Contaldo N. Orlandini G. Cavicchi L. Genovese S. Bertelli D. Benvenuti S. Curini M. Bertaccini A. Bellardi M.G. Chromatographic methods for metabolite profiling of virus- and phytoplasma-infected plants of Echinacea purpurea J Agric Food Chem 2011 59 10425 1043410.1021/jf202567721830789Search in Google Scholar

18Pimenta E.M., De S., Weiss R., Feng D., Hall K., Kilic S., Bhanot G., Ganesan S., Ran S., Barnes B.J.: IRF5 is a novel regulator of CXCL13 expression in breast cancer that regulates CXCR5+ B‐and T‐cell trafficking to tumor‐conditioned media. Immunol Cell Biol 2015, 93, 486–499. Pimenta E.M. De S. Weiss R. Feng D. Hall K. Kilic S. Bhanot G. Ganesan S. Ran S. Barnes B.J. IRF5 is a novel regulator of CXCL13 expression in breast cancer that regulates CXCR5+ B‐and T‐cell trafficking to tumor‐conditioned media Immunol Cell Biol 2015 93 486 49910.1038/icb.2014.11025533286Search in Google Scholar

19Russo R.C., Garcia C.C., Teixeira M.M., Amaral F.A.: The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases. Expert Rev Clin Immunol 2014, 10, 593–619. Russo R.C. Garcia C.C. Teixeira M.M. Amaral F.A. The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases Expert Rev Clin Immunol 2014 10 593 61910.1586/1744666X.2014.89488624678812Search in Google Scholar

20Takashi K., Matthew C.W., Yongwon C.: The role of TRAF6 in signal transduction and the immune response. Microbes Infect 2004, 6, 1333–1338. Takashi K. Matthew C.W. Yongwon C. The role of TRAF6 in signal transduction and the immune response Microbes Infect 2004 6 1333 133810.1016/j.micinf.2004.09.00115555541Search in Google Scholar

21Tanaka T., Narazaki M., Kishimoto T.: IL-6 in inflammation, immunity, and disease. Csh Perspect Biol 2014, 6, a016295. Tanaka T. Narazaki M. Kishimoto T. IL-6 in inflammation, immunity, and disease Csh Perspect Biol 2014 6 a01629510.1101/cshperspect.a016295417600725190079Search in Google Scholar

22Taro K., Shizuo A.: The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 2010, 11, 373–384. Taro K. Shizuo A. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors Nat Immunol 2010 11 373 38410.1038/ni.186320404851Search in Google Scholar

23Tergaonkar V.: NF-κB pathway: A good signaling paradigm and therapeutic target. Int J Biochem Cell Biol 2006, 38, 1647–1653. Tergaonkar V. NF-κB pathway: A good signaling paradigm and therapeutic target Int J Biochem Cell Biol 2006 38 1647 165310.1016/j.biocel.2006.03.02316766221Search in Google Scholar

24Waszak P., Thébaud B.: Lung development and mesenchymal stem cells. Arch Pediatr 2011, 18 Suppl 2, 86–91. Waszak P. Thébaud B. Lung development and mesenchymal stem cells Arch Pediatr 2011 18 Suppl 2 86–91Search in Google Scholar

25Wu H., Alessandro N., Nicola L.: Effects of a standardized purified dry extract from Echinacea angustifolia on proliferation and interferon gamma secretion of peripheral blood mononuclear cells in dairy heifers. Res Vet Sci 2009, 87, 396–398. Wu H. Alessandro N. Nicola L. Effects of a standardized purified dry extract from Echinacea angustifolia on proliferation and interferon gamma secretion of peripheral blood mononuclear cells in dairy heifers Res Vet Sci 2009 87 396 39810.1016/j.rvsc.2009.05.00519482325Search in Google Scholar

26Xi H., Zhang Y.L., Xu Y.J., Yang W.Y, Jiang X.H., Sha X.J., Cheng X.S., Wang J.F., Qin X.B., Yu J., Ji Y., Yang X.F., Wang H.: Caspase-1 Inflammasome Activation Mediates Homocysteine-Induced Pyrop-Apoptosis in Endothelial Cells. Circ Res 2016, 118, 1525–1539. Xi H. Zhang Y.L. Xu Y.J. Yang W.Y Jiang X.H. Sha X.J. Cheng X.S. Wang J.F. Qin X.B. Yu J. Ji Y. Yang X.F. Wang H. Caspase-1 Inflammasome Activation Mediates Homocysteine-Induced Pyrop-Apoptosis in Endothelial Cells Circ Res 2016 118 1525 153910.1161/CIRCRESAHA.116.308501486713127006445Search in Google Scholar

27Yassine A.: Modulation of Airway Smooth Muscle Contractile Function by TNF-α and IL-13 and Airway Hyperresponsiveness in Asthma. Calcium Signaling In Airway Smooth Muscle Cells. Spr Int Publing 2014. Yassine A. Modulation of Airway Smooth Muscle Contractile Function by TNF-α and IL-13 and Airway Hyperresponsiveness in Asthma. Calcium Signaling In Airway Smooth Muscle Cells Spr Int Publing 2014Search in Google Scholar

28Yi L., Huang X.Q., Guo F., Zhou Z.D., Chang M.L., Tang J.J., Huan J.N.: Lipopolysaccharide Induces Human Pulmonary Micro-Vasular Endothelial Apoptosis via the YAP Signaling Pathway. Front Cell Infect Microbiol 2016, 6, 133. Yi L. Huang X.Q. Guo F. Zhou Z.D. Chang M.L. Tang J.J. Huan J.N. Lipopolysaccharide Induces Human Pulmonary Micro-Vasular Endothelial Apoptosis via the YAP Signaling Pathway Front Cell Infect Microbiol 2016 6 13310.3389/fcimb.2016.00133506940527807512Search in Google Scholar

29Zhang J., Kong X.H., Zhou C.J., Li L., Nie G.X., Li X.J.: Toll-like receptor recognition of bacteria in fish: Ligand specificity and signal pathways. Fish and Shellfish Immunology 2014, 41, 380–388. Zhang J. Kong X.H. Zhou C.J. Li L. Nie G.X. Li X.J. Toll-like receptor recognition of bacteria in fish: Ligand specificity and signal pathways Fish and Shellfish Immunology 2014 41 380 38810.1016/j.fsi.2014.09.02225241605Search in Google Scholar

30Zou Z.H., Dong L.W, Wang H.G., Niu J.J., Zou M.W., Wu N.T., Yu D.B., Wang Y W.: Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1. Oncotargets Ther 2015, 3649–3664. Zou Z.H. Dong L.W Wang H.G. Niu J.J. Zou M.W. Wu N.T. Yu D.B. Wang Y W. Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1 Oncotargets Ther 2015 3649 366410.2147/OTT.S94513467776326677335Search in Google Scholar