Pre-Incubation of Probiotics Before Intake: A Reasonable Recommendation?

1 Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term pro-biotic. Nat Rev Gastroenterol Hepatol 2014 Aug; 11(8): 506–514. https://doi.org/10.1038/nrgastro.2014.66. Epub 2014 Jun 10. PMID: 24912386. Search in Google Scholar

2 Kim SK, Guevarra RB, Kim YT, Kwon J, Kim H, Cho JH, Kim HB, Lee JH. Role of Probiotics in Human Gut Microbiome-Associated Diseases. J Microbiol Biotechnol 2019 Sep 28; 29(9): 1335–1340. https://doi.org/10.4014/jmb.1906.06064. PMID: 31434172. Search in Google Scholar

3 Plaza-Diaz J, Ruiz-Ojeda FJ, Gil-Campos M, Gil A. Mechanisms of Action of Probiotics. Adv Nutr 2019 Jan 1; 10(suppl_1): S49–S66. https://doi.org/10.1093/advances/nmy063. Erratum in: Adv Nutr 2020 Jul 1; 11(4): 1054. PMID: 30721959; PMCID: PMC6363529. Search in Google Scholar

4 Alagozlu H, Karakan T. Probiotics are sensitive microorganisms: Lacto-bacillus can be affected by stomach acid, antibiotic, and bowel cleansing. Dig Dis Sci 2012 Sep; 57(9): 2477–2478; author reply 2477–2478. https://doi.org/10.1007/s10620–012–2310–5. Epub 2012 Jul 18. PMID: 22806546. Search in Google Scholar

5 Engevik AC, Kaji I, Goldenring JR. The Physiology of the Gastric Parietal Cell. Physiol Rev 2020 Apr 1; 100(2): 573–602. https://doi.org/10.1152/physrev.00016.2019. Epub 2019 Oct 31. PMID: 31670611; PMCID: PMC7327232. Search in Google Scholar

6 Baral KC, Bajracharya R, Lee SH, Han HK. Advancements in the Pharmaceutical Applications of Probiotics: Dosage Forms and Formulation Technology. Int J Nanomedicine 2021 Nov 12; 16: 7535–7556. https://doi.org/10.2147/IJN.S337427. PMID: 34795482; PMCID: PMC8594788. Search in Google Scholar

7 Piątek J, Gibas-Dorna M, Olejnik A, Krauss H, Wierzbicki K, Żukiewicz-Sobczak W, Głowacki M. The viability and intestinal epithelial cell adhesion of probiotic strain combination – in vitro study. Ann Agric Environ Med 2012; 19(1): 99–102. PMID: 22462453. Search in Google Scholar

8 Omni-Biotic®10 [online]. Retrieved from https://www.omni-biotic.com/de/produkte/omni-biotic-10/ [cited 21.06.23]. Search in Google Scholar