Is Carboxyhaemoglobin an Effective Bedside Prognostic Tool for Sepsis and Septic Shock Patients?

Bianca-Liana Grigorescu; Oana Coman; Anca Meda Văsieșiu; Anca Bacârea; Marius Petrișor; Irina Săplăcan; Raluca Ștefania Fodor

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Is Carboxyhaemoglobin an Effective Bedside Prognostic Tool for Sepsis and Septic Shock Patients?

Bianca-Liana Grigorescu

oraz

Raluca Ștefania Fodor

| 14 lis 2023

The Journal of Critical Care Medicine

Tom 9 (2023): Zeszyt 4 (October 2023)

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Article Category: Research Article

Data publikacji: 14 lis 2023

Zakres stron: 239 - 251

Otrzymano: 22 wrz 2023

Przyjęty: 22 paź 2023

DOI: https://doi.org/10.2478/jccm-2023-0031

Słowa kluczowe
sepsis, septic shock, SOFA, APACHE II, SAPS II, carboxyhaemoglobin, neutrophil-to-lymphocyte ratio

© 2023 Bianca-Liana Grigorescu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Visual description of the study (N – number of patients; SOFA - Sequential Organ Failure Assessment; APACHE II - Acute Physiology and Chronic Health Evaluation II; SAPS II - Simplified Acute Physiology Score II)

Positive correlation between SOFA vs. APACHE II and SOFA vs. SAPS II. No correlation between SOFA vs. NLR and SOFA vs. COHb levels on D1 (SOFA – Sequential Organ Failure Assessment; APACHE II – Acute Physiology and Chronic Health Evaluation II; SAPS II – Simplified Acute Physiology Score II; NLR – Neutrophil-Lymphocytes Ratio; COHb – Carboxyhaemoglobin; D1 – day 1)

Positive correlation between APACHE II vs. SAPS II. No correlation between APACHE II vs. NLR, APACHE II vs. COHb levels on D1 (APACHE II – Acute Physiology and Chronic Health Evaluation II; SAPS II – Simplified Acute Physiology Score II; NLR – Neutrophil-Lymphocytes Ratio; COHb – Carboxyhaemoglobin; D1 – day 1)

No correlation between SAPS II vs. NLR, SAPS II vs. COHb levels on D1 (SAPS II – Simplified Acute Physiology Score II; NLR – Neutrophil-Lymphocytes Ratio; COHb – Carboxyhaemoglobin; D1 – day 1)

Negative correlation between NLR vs. COHb on D1 (NLR – Neutrophil-Lymphocytes Ratio; COHb – Carboxyhaemoglobin; D1 – day 1)

Positive correlation between SOFA vs. APACHE II, SOFA vs. SAPS II. No correlation between SOFA vs. NLR and SOFA vs. COHb levels on D5 (SOFA – Sequential Organ Failure Assessment; APACHE II – Acute Physiology and Chronic Health Evaluation II; SAPS II – Simplified Acute Physiology Score II; NLR – Neutrophil-Lymphocytes Ratio; COHb – Carboxyhaemoglobin; D5 – day 5)

Positive correlation between APACHE II vs. SAPS II. No correlation between APACHE II vs. NLR, APACHE II vs. COHb levels on D5 (APACHE II – Acute Physiology and Chronic Health Evaluation II; SAPS II – Simplified Acute Physiology Score II; NLR – Neutrophil-Lymphocytes Ratio; COHb – Carboxyhaemoglobin; D5 – day 5)

No correlation between SAPS II vs. NLR, SAPS II vs. COHb levels on D5 (SAPS II – Simplified Acute Physiology Score II; NLR – Neutrophil-Lymphocytes Ratio; COHb – Carboxyhaemoglobin; D5 – day 5)

No correlation between NLR vs. COHb on D5 (NLR – Neutrophil-Lymphocytes Ratio; COHb – Carboxyhaemoglobin; D5 – day 5)

Evolution of NLR on D1 and D5 in sepsis survivors and non-survivors (NLR – Neutrophil-Lymphocytes Ratio; D1 – day 1; D5 – day 5)

Evolution of NLR on D1 and D5 in septic shock survivors and non-survivors (NLR – Neutrophil-Lymphocytes Ratio; SS – septic shock; D1 – day 1; D5 – day 5)

Evolution of COHb (%) on D1 and D5 in sepsis survivors and non-survivors (COHb – Carboxyhaemoglobin; D1 – day 1; D5 – day 5)

Evolution of COHb (%) on D1 and D5 in septic shock survivors and non-survivors (COHb – Carboxyhaemoglobin; SS – septic shock; D1 – day 1; D5 – day 5)

Descriptive statistics on D1

	SOFA	APACHE II (points)	SAPS II (points)	NLR	COHb
Minimum	1.000	7.000	17.00	0.7420	0.000
25% Percentile	6.000	14.00	34.50	8.236	0.4250
Median	9.000	22.00	56.00	14.14	1.100
75% Percentile	13.00	30.00	72.00	25.01	1.500
Maximum	19.00	44.00	118.0	59.67	2.500
Range	18.00	37.00	101.0	58.93	2.500
Mean	9.459	22.30	54.61	17.06	1.080
Std.Deviation	4.700	9.426	21.84	11.76	0.6356
Std. Error of Mean	0.6017	1.207	2.796	1.505	0.08206

Site of infection and aetiology of infection of patients included in the study.

Site of infection	Number of patients	Aetiology	Number of patients
Pulmonary	36	Pneumonia / Bronchopneumonia	33
Abdominal	27	Peritonitis	12
Cutaneous	5	Intestinal obstruction	5
Urinary tract	4	Enterocolitis	2
Bloodstream	3	Sepsis / septic shock of unknown origin	2
Soft tissue	3	Pancreatitis	3
Biliary tract	1	Urinary tract infection	2
Unspecified	1	Cutaneous abscess	5
		Prosthetic joint infection	1

Descriptive statistics on D5

	SOFA	APACHE II (points)	SAPS II (points)	NLR	COHb
Minimum	0.000	5.000	15.00	0.7860	0.000
25% Percentile	2.000	11.00	29.00	5.422	0.600
Median	7.000	18.00	46.00	9.005	1.000
75% Percentile	12.00	27.00	61.00	17.87	1.500
Maximum	19.00	34.00	85.00	46.75	17.00
Range	19.00	29.00	70.00	45.96	17.00
Mean	7.359	18.74	45.36	13.03	1.471
Std. Deviation	5.334	9.318	20.40	10.84	2.550
Std. Error of Mean	0.8541	1.492	3.267	1.714	0.3982

Pathogens associated with infection of patients involved in the study.

Pathogens		Number of patients
Pseudomonas aeruginosa		9

Klebsiella pneumoniae	CPE	8
	BLSE	2
	unspecified	2

Acinetobacter baumanii		13

Proteus vulgaris		2

Enterococcus faecalis		5

Escherichia coli	BLSE	4
Escherichia coli	unspecified	3

Staphylococcus arureus	MRSA	1
Staphylococcus arureus	MSSA	2

Streptococcus pneumoniae		1

Candida spp.		8

Clostridiumdifficile		3

Other		16

MDR	Yes	13
MDR	No	48

Predictability of mortality by NLR and COHb variation from D1 to D5 of survivors and non-survivors

	Survivors (n = 15)	Non-survivors (n = 46)
NLRD1 ↓ D5 and COHb D1 ↓ D5	11	9
NLRD1 ↓ D5 and COHb D1 ↑ D5	1	14
NLRD1 ↑ D5 and COHb D1 ↑ D5	2	3
NLRD1 ↑ D5 and COHb D1 ↓ D5	0	4
NLR only on D1 and COHb only on D1	1	16

eISSN:: 2393-1817
Język:: Angielski

Częstotliwość wydawania:: 4 razy w roku
Dziedziny czasopisma:: Medicine, Clinical Medicine, Internal Medicine, other, Surgery, Anaesthesiology, Emergency Medicine and Intensive-Care Medicine

Kanał RSS czasopisma

Is Carboxyhaemoglobin an Effective Bedside Prognostic Tool for Sepsis and Septic Shock Patients?

Article Category: Research Article

Data publikacji: 14 lis 2023

Zakres stron: 239 - 251

Otrzymano: 22 wrz 2023

Przyjęty: 22 paź 2023

DOI: https://doi.org/10.2478/jccm-2023-0031

Słowa kluczowe
sepsis, septic shock, SOFA, APACHE II, SAPS II, carboxyhaemoglobin, neutrophil-to-lymphocyte ratio

© 2023 Bianca-Liana Grigorescu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

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Descriptive statistics on D1

Site of infection and aetiology of infection of patients included in the study.

Descriptive statistics on D5

Pathogens associated with infection of patients involved in the study.

Predictability of mortality by NLR and COHb variation from D1 to D5 of survivors and non-survivors

Is Carboxyhaemoglobin an Effective Bedside Prognostic Tool for Sepsis and Septic Shock Patients?

Article Category: Research Article

Data publikacji: 14 lis 2023

Zakres stron: 239 - 251

Otrzymano: 22 wrz 2023

Przyjęty: 22 paź 2023

DOI: https://doi.org/10.2478/jccm-2023-0031

Słowa kluczowesepsis, septic shock, SOFA, APACHE II, SAPS II, carboxyhaemoglobin, neutrophil-to-lymphocyte ratio

© 2023 Bianca-Liana Grigorescu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Fig. 1.

Figure 2.

Figure 3.

Fig. 4.

Fig. 5.

Fig. 6.

Fig. 7.

Fig. 8.

Fig. 9.

Fig. 10.

Fig. 11.

Fig. 12.

Fig. 13.

Fig. 14.

Fig. 15.

Descriptive statistics on D1

Site of infection and aetiology of infection of patients included in the study.

Descriptive statistics on D5

Pathogens associated with infection of patients involved in the study.

Predictability of mortality by NLR and COHb variation from D1 to D5 of survivors and non-survivors

Słowa kluczowe
sepsis, septic shock, SOFA, APACHE II, SAPS II, carboxyhaemoglobin, neutrophil-to-lymphocyte ratio