<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Introduction</h3>
<p>Proper management of sepsis poses a challenge even today, with early diagnosis and targeted treatment being the most important steps. Easy, cost-effective bedside tools are needed in order to pinpoint towards the outcome of sepsis or septic shock.</p>
</sec>
<sec><h3>Aim of study</h3>
<p>This study aims to find a correlation between Sequential Organ Failure Assessment (SOFA), Acute Physiology and Chronic Health Evaluation II (APACHE II) and Simplified Acute Physiology Score II (SAPS II) severity scores, the Neutrophil-Lymphocytes Ratio (NLR) and carboxyhaemoglobin (COHb) levels in septic or septic shock patients with the scope of establishing a bed side cost-effective prognostic tool.</p>
</sec>
<sec><h3>Materials and methods</h3>
<p>A pilot, prospective, observational, and ongoing study was conducted on 61 patients admitted with sepsis or septic shock according to the SEPSIS 3 Consensus definition. We followed clinical and paraclinical parameters on day 1 (D1) and day 5 (D5) after meeting the inclusion criteria.</p>
</sec>
<sec><h3>Results</h3>
<p>On D1 we found a statistically significant positive correlation between each severity score (p &lt;0.0001), r = 0.7287 for SOFA vs. APACHE II with CI: 0.5841–0.8285, r = 0.6862 for SOFA vs. SAPS II with CI: 0.5251–0.7998 and r = 0.8534 for APACHE II vs. SAPS II with CI: 0.7663 to 0.9097. On D5 we observed similar results: a significant positive correlation between each severity score (p &lt;0.0001), with r = 0.7877 for SOFA vs. APACHE II with CI: 0.6283 to 0.8836, r = 0.8210 for SOFA vs. SAPS II with CI: 0.6822 to 0.9027 and r = 0.8880 for APACHE II vs. SAPS II., CI: 0.7952 to 0.9401. Nil correlation was found between the severity scores, NLR and COHb on D1 and D5.</p>
</sec>
<sec><h3>Conclusion</h3>
<p>Cost-effective bedside tools to pinpoint towards the outcome of sepsis are yet to be found, however the positive correlation between the severity scores point out to a combination of such tools for prognosis prediction of septic or septic shock patients.</p>
</sec>
</abstract>

Introduction
Proper management of sepsis poses a challenge even today, with early diagnosis and targeted treatment being the most important steps. Easy, cost-effective bedside tools are needed in order to pinpoint towards the outcome of sepsis or septic shock.

Aim of study
This study aims to find a correlation between Sequential Organ Failure Assessment (SOFA), Acute Physiology and Chronic Health Evaluation II (APACHE II) and Simplified Acute Physiology Score II (SAPS II) severity scores, the Neutrophil-Lymphocytes Ratio (NLR) and carboxyhaemoglobin (COHb) levels in septic or septic shock patients with the scope of establishing a bed side cost-effective prognostic tool.

Materials and methods
A pilot, prospective, observational, and ongoing study was conducted on 61 patients admitted with sepsis or septic shock according to the SEPSIS 3 Consensus definition. We followed clinical and paraclinical parameters on day 1 (D1) and day 5 (D5) after meeting the inclusion criteria.

Results
On D1 we found a statistically significant positive correlation between each severity score (p <0.0001), r = 0.7287 for SOFA vs. APACHE II with CI: 0.5841–0.8285, r = 0.6862 for SOFA vs. SAPS II with CI: 0.5251–0.7998 and r = 0.8534 for APACHE II vs. SAPS II with CI: 0.7663 to 0.9097. On D5 we observed similar results: a significant positive correlation between each severity score (p <0.0001), with r = 0.7877 for SOFA vs. APACHE II with CI: 0.6283 to 0.8836, r = 0.8210 for SOFA vs. SAPS II with CI: 0.6822 to 0.9027 and r = 0.8880 for APACHE II vs. SAPS II., CI: 0.7952 to 0.9401. Nil correlation was found between the severity scores, NLR and COHb on D1 and D5.

Conclusion
Cost-effective bedside tools to pinpoint towards the outcome of sepsis are yet to be found, however the positive correlation between the severity scores point out to a combination of such tools for prognosis prediction of septic or septic shock patients.

Is Carboxyhaemoglobin an Effective Bedside Prognostic Tool for Sepsis and Septic Shock Patients?

Department of Anesthesia and Intensive Care

George Emil Palade University of Medicine

Department of Simulation Applied in Medicine

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

Introduction
Proper management of sepsis poses a challenge even today, with early diagnosis and targeted treatment being the most important steps. Easy,...

Is Carboxyhaemoglobin an Effective Bedside Prognostic Tool for Sepsis and Septic Shock Patients?

Article Category: Research Article

Data publikacji: 14 lis 2023

Zakres stron: 239 - 251

Otrzymano: 22 wrz 2023

Przyjęty: 22 paź 2023

DOI: https://doi.org/10.2478/jccm-2023-0031

Słowa kluczowe
sepsis, septic shock, SOFA, APACHE II, SAPS II, carboxyhaemoglobin, neutrophil-to-lymphocyte ratio

© 2023 Bianca-Liana Grigorescu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Is Carboxyhaemoglobin an Effective Bedside Prognostic Tool for Sepsis and Septic Shock Patients?

Article Category: Research Article

Data publikacji: 14 lis 2023

Zakres stron: 239 - 251

Otrzymano: 22 wrz 2023

Przyjęty: 22 paź 2023

DOI: https://doi.org/10.2478/jccm-2023-0031

Słowa kluczowesepsis, septic shock, SOFA, APACHE II, SAPS II, carboxyhaemoglobin, neutrophil-to-lymphocyte ratio

© 2023 Bianca-Liana Grigorescu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Słowa kluczowe
sepsis, septic shock, SOFA, APACHE II, SAPS II, carboxyhaemoglobin, neutrophil-to-lymphocyte ratio