<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Objective</h3>
<p>To evaluate the adjuvant treatment of acute stage symptoms and quality of life of patients with bullous pemphigoid (BP) with ozone.</p>
</sec>
<sec><h3>Methods</h3>
<p>We included 74 patients with moderate and severe BP hospitalized from July 2018 to December 2020. The participants were randomly divided into the control group and the ozone group, with 37 patients in each group (n = 37). The control group used tap water to wash the whole body, and mupirocin ointment was used for the erosions. The ozone group used ozone water to wash the whole body, and the erosion place was coated with ozone oil. The bullous pemphigoid disease area index (BPDAI) score of BP disease was used to observe the clinical symptoms and skin lesions of the two groups before and on day 3, 7, and 14 after treatment. Pruritus and sleep were observed before and on day 3, 7, and 14 after treatment. The Dermatology Life Quality Index (DLQI) was used to observe the quality of life before and after treatment and the adverse reactions were recorded.</p>
</sec>
<sec><h3>Results</h3>
<p>The total BPDAI score and erythema score in the ozone group were significantly different from those in the control group on day 3, 7, and 14 after treatment (<italic>P</italic> &lt; 0.050). The scab drying time and erosion drying time of ozone group were shorter than that of control group (<italic>P</italic> &lt; 0.001). There were statistically significant differences between the ozone group and the control group in pruritus score and sleep score on day 3, 7, and 14 after treatment (<italic>P</italic> &lt; 0.001). There was statistically significant difference in skin disease quality of life between the two groups 14 days after treatment (<italic>P</italic> &lt; 0.001). No significant adverse reactions and complications were observed in both groups.</p>
</sec>
<sec><h3>Conclusions</h3>
<p>Ozone external use can rapidly improve the acute stage of edema erythema, erosion, and itching of BP, improve the quality of life of patients, is an effective treatment method, and worthy of clinical promotion.</p>
</sec>
</abstract>

Objective
To evaluate the adjuvant treatment of acute stage symptoms and quality of life of patients with bullous pemphigoid (BP) with ozone.

Methods
We included 74 patients with moderate and severe BP hospitalized from July 2018 to December 2020. The participants were randomly divided into the control group and the ozone group, with 37 patients in each group (n = 37). The control group used tap water to wash the whole body, and mupirocin ointment was used for the erosions. The ozone group used ozone water to wash the whole body, and the erosion place was coated with ozone oil. The bullous pemphigoid disease area index (BPDAI) score of BP disease was used to observe the clinical symptoms and skin lesions of the two groups before and on day 3, 7, and 14 after treatment. Pruritus and sleep were observed before and on day 3, 7, and 14 after treatment. The Dermatology Life Quality Index (DLQI) was used to observe the quality of life before and after treatment and the adverse reactions were recorded.

Results
The total BPDAI score and erythema score in the ozone group were significantly different from those in the control group on day 3, 7, and 14 after treatment (P < 0.050). The scab drying time and erosion drying time of ozone group were shorter than that of control group (P < 0.001). There were statistically significant differences between the ozone group and the control group in pruritus score and sleep score on day 3, 7, and 14 after treatment (P < 0.001). There was statistically significant difference in skin disease quality of life between the two groups 14 days after treatment (P < 0.001). No significant adverse reactions and complications were observed in both groups.

Conclusions
Ozone external use can rapidly improve the acute stage of edema erythema, erosion, and itching of BP, improve the quality of life of patients, is an effective treatment method, and worthy of clinical promotion.

Topical use of ozone effectively alleviates the acute symptoms and quality of life of patients with moderate to severe bullous pemphigoid: a randomized controlled trial<xref ref-type="fn" rid="j_fon-2020-0024_fn_001"><sup>†</sup></xref>

First Hospital of Shanxi Medical University

Frontiers of Nursing

This work is licensed under the Creative Commons Attribution 4.0 International License.

Topical use of ozone effectively alleviates the acute symptoms and quality of life of patients with moderate to severe bullous pemphigoid: a randomized controlled trial

Objective
To evaluate the adjuvant treatment of acute stage symptoms and quality of life of patients with bullous pemphigoid (BP) with ozone.

Methods
We...

Index	Cases	Gender		Age (years)	BPDAI score

		Male	Female
Ozone group	37	18	19	75.50 ± 7.65	162.16 ± 23.37
Control group	37	16	21	74.70 ± 8.18	164.22 ± 22.12
t/χ²		0.218		−0.352	0.388
P		0.816		0.726	0.699

Indicators	Variable	F	P
BPDAI
	Time of therapy	813.319	<0.001
	Group	16.562	<0.001
	Time*Group	8.217	0.001
Vesicle
	Time of therapy	558.974	<0.001
	Group	0.253	0.616
	Time*Group	0.224	0.791
Erythema
	Time of therapy	259.040	<0.001
	Group	16.944	<0.001
	Time*Group	11.182	<0.001
Skin lesion
	Time of therapy	366.323	<0.001
	Group	0.002	0.960
	Time*Group	0.339	0.718

Topical use of ozone effectively alleviates the acute symptoms and quality of life of patients with moderate to severe bullous pemphigoid: a randomized controlled trial^†

Article Category: Original article

Data publikacji: 21 wrz 2021

Zakres stron: 233 - 240

Otrzymano: 01 kwi 2021

Przyjęty: 09 cze 2021

DOI: https://doi.org/10.2478/fon-2020-0024

Słowa kluczowe
bullous pemphigoid, erosion, erythema, external use, itch, moderate-severe, ozone, quality of life

© 2021 Li Li et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Comparison of basic data between two groups of patients.

The test of different effect of BPDAI observation index.

Topical use of ozone effectively alleviates the acute symptoms and quality of life of patients with moderate to severe bullous pemphigoid: a randomized controlled trial†

Article Category: Original article

Data publikacji: 21 wrz 2021

Zakres stron: 233 - 240

Otrzymano: 01 kwi 2021

Przyjęty: 09 cze 2021

DOI: https://doi.org/10.2478/fon-2020-0024

Słowa kluczowebullous pemphigoid, erosion, erythema, external use, itch, moderate-severe, ozone, quality of life

© 2021 Li Li et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Comparison of basic data between two groups of patients.

The test of different effect of BPDAI observation index.

Topical use of ozone effectively alleviates the acute symptoms and quality of life of patients with moderate to severe bullous pemphigoid: a randomized controlled trial^†

Słowa kluczowe
bullous pemphigoid, erosion, erythema, external use, itch, moderate-severe, ozone, quality of life