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Topical use of ozone effectively alleviates the acute symptoms and quality of life of patients with moderate to severe bullous pemphigoid: a randomized controlled trial†

Li Li

Li Li

Department of Dermatology, First Hospital of Shanxi Medical UniversityTaiyuan, China
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Li, Li
, 
Li-Yun Sang

Li-Yun Sang

Department of Dermatology, First Hospital of Shanxi Medical UniversityTaiyuan, China
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Sang, Li-Yun
, 
Wen-Guang Zhang

Wen-Guang Zhang

Department of Nursing, First Hospital of Shanxi Medical UniversityTaiyuan, China
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Zhang, Wen-Guang
, 
Tong Wang

Tong Wang

School of Public Health, Shanxi Medical UniversityTaiyuan, China
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Wang, Tong
, 
Shu-Ping Guo

Shu-Ping Guo

Department of Dermatology, First Hospital of Shanxi Medical UniversityTaiyuan, China
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Guo, Shu-Ping
, 
Hong-Zhou Cui

Hong-Zhou Cui

Department of Dermatology, First Hospital of Shanxi Medical UniversityTaiyuan, China
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Cui, Hong-Zhou
 and 
Hong-Ye Liu

Hong-Ye Liu

Department of Dermatology, First Hospital of Shanxi Medical UniversityTaiyuan, China
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Liu, Hong-Ye
  
Sep 21, 2021
Topical use of ozone effectively alleviates the acute symptoms and quality of life of patients with moderate to severe bullous pemphigoid: a randomized controlled trial†'s Cover Image
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Article Category: Original article
Published Online: Sep 21, 2021
Page range: 233 - 240
Received: Apr 01, 2021
Accepted: Jun 09, 2021
DOI: https://doi.org/10.2478/fon-2020-0024
Keywords
© 2021 Li Li et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Figure 1

Research object screening flow chart. BPDAI, bullous pemphigoid disease area index.
Research object screening flow chart. BPDAI, bullous pemphigoid disease area index.

Figure 2

Different treatment vesicle dry scab, erosion drying time (day) box chart.
Different treatment vesicle dry scab, erosion drying time (day) box chart.

Figure 3

Contour plots of itch scores of the two groups at different times.
Contour plots of itch scores of the two groups at different times.

Figure 4

Sleep score profiles of the two groups at different times.
Sleep score profiles of the two groups at different times.

Figure 5

Comparison of DLQI scores before and after different treatments (score) box chart.
Comparison of DLQI scores before and after different treatments (score) box chart.

Comparison of basic data between two groups of patients_

Index Cases Gender Age (years) BPDAI score
Male Female
Ozone group 37 18 19 75.50 ± 7.65 162.16 ± 23.37
Control group 37 16 21 74.70 ± 8.18 164.22 ± 22.12
t/χ2 0.218 −0.352 0.388
P 0.816 0.726 0.699

The test of different effect of BPDAI observation index_

Indicators Variable F P
BPDAI
Time of therapy 813.319 <0.001
Group 16.562 <0.001
Time*Group 8.217 0.001
Vesicle
Time of therapy 558.974 <0.001
Group 0.253 0.616
Time*Group 0.224 0.791
Erythema
Time of therapy 259.040 <0.001
Group 16.944 <0.001
Time*Group 11.182 <0.001
Skin lesion
Time of therapy 366.323 <0.001
Group 0.002 0.960
Time*Group 0.339 0.718
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