Otwarty dostęp

Medication Related Osteonecrosis of the Jaw (MRONJ). Review and recent advances

Dimitra Galiti
Dimitra Galiti
, 
Aikaterini Karayianni
Aikaterini Karayianni
, 
Kostas Tsiklakis
Kostas Tsiklakis
 oraz 
Amanda Psyrri
Amanda Psyrri
   | 27 mar 2023
Forum of Clinical Oncology's Cover Image
O artykule
Poprzedni artykuł
Następny artykuł
Zacytuj
Article Category: Review
Data publikacji: 27 mar 2023
Zakres stron: 38 - 47
Otrzymano: 22 mar 2018
Przyjęty: 17 mar 2019
DOI: https://doi.org/10.2478/fco-2022-0005
Słowa kluczowe
© 2022 Dimitra Galiti et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

Osteonecrosis of the maxilla, presenting as exposed necrotic bone (compact arrow), after a dental extraction. Sockets without teeth (phantom sockets) (transparent arrow), are seen on the necrotic bone. Patient was asymptomatic at presentation.
Osteonecrosis of the maxilla, presenting as exposed necrotic bone (compact arrow), after a dental extraction. Sockets without teeth (phantom sockets) (transparent arrow), are seen on the necrotic bone. Patient was asymptomatic at presentation.

Figure 2

Osteonecrosis on the maxilla was diagnosed after probing necrotic bone through a fistula (arrow). A plastic material (gutaperka) was inserted into the fistula to better disclose the fistula. Patient presented with pain and swelling.
Osteonecrosis on the maxilla was diagnosed after probing necrotic bone through a fistula (arrow). A plastic material (gutaperka) was inserted into the fistula to better disclose the fistula. Patient presented with pain and swelling.

Figure 3

Panoramic radiograph of a cancer patient, who received antiresorptives and presented with a non-healing socket (phantom socket) two months after the dental extraction of the mandibular molar tooth. Patient was diagnosed with MRONJ stage 2.
Panoramic radiograph of a cancer patient, who received antiresorptives and presented with a non-healing socket (phantom socket) two months after the dental extraction of the mandibular molar tooth. Patient was diagnosed with MRONJ stage 2.

Figure 4

Cone Beam Computed Tomography of a cancer patient, who received antiresorptives. Osteolytic areas (arrows) and bone sequestrum (stars) are observed in the maxilla. Fullness of left sinus is also seen (asterisks). Patient was diagnosed with MRONJ stage 3.
Cone Beam Computed Tomography of a cancer patient, who received antiresorptives. Osteolytic areas (arrows) and bone sequestrum (stars) are observed in the maxilla. Fullness of left sinus is also seen (asterisks). Patient was diagnosed with MRONJ stage 3.

MRONJ Stages, American Association of Oral and Maxillofacial Surgeons 2014

Stage 0 Stage 1 Stage 2 Stage 3
Clinical definitions

Without clinical evidence of necrotic bone

With nonspecific clinical findings

With symptoms

Exposed and necrotic bone or fistula probing the bone

Asymptomatic patients

No evidence of infection

Exposed and necrotic bone or fistula probing the bone

Infection evident by pain and erythema at the site of the exposed bone with or without purulent drainage

Exposed and necrotic bone or fistula probing the bone

Symptoms of pain and infection

Extraoral fistula

Oral antral or oral nasal communication
Radiographic features

Alveolar bone loss, resorption not attributed to periodontal disease

Trabecular pattern changes

Dense bone

Lamina dura thickening

Decreased periodontal ligament space

Radiological findings localized to the alveolar bone

Radiological findings localized to the alveolar bone

Findings extending beyond the region of alveolar bone

Pathologic fracture

Osteolysis extending to the inferior border of the mandible or sinus floor
eISSN:
1792-362X
Język:
Angielski
Częstotliwość wydawania:
4 razy w roku
Dziedziny czasopisma:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology
Kanał RSS czasopisma