1. bookTom 6 (2022): Zeszyt 3 (July 2022)
Informacje o czasopiśmie
License
Format
Czasopismo
eISSN
2564-615X
Pierwsze wydanie
30 Jan 2017
Częstotliwość wydawania
4 razy w roku
Języki
Angielski
access type Otwarty dostęp

Association of the 5HTR2C gene Ser23 variation with childhood allergic asthma

Data publikacji: 18 Jul 2022
Tom & Zeszyt: Tom 6 (2022) - Zeszyt 3 (July 2022)
Zakres stron: 126 - 132
Informacje o czasopiśmie
License
Format
Czasopismo
eISSN
2564-615X
Pierwsze wydanie
30 Jan 2017
Częstotliwość wydawania
4 razy w roku
Języki
Angielski
Abstract

Objective: Allergic asthma is the most frequently observed subtype of individuals with asthma. The effects of serotonin plays in the pathophysiology of asthma has not been clearly determined. Thus, this study aimed to investigate the association between the 5HTR2C gene rs 6318 G>C polymorphism and allergic asthma in pediatric patients in Cyprus.

Methods: This study included total number of 177 individuals with 118 control and 59 pediatric patients (43 atopic and 16 non-atopic asthma patient). A skin prick test was performed for each patient to confirm asthma diagnosis and to evaluate atopic status. Genotyping for the 5HTR2C was completed by Real Time-PCR analysis.

Results: The genotype distribution frequencies were not in agreement with the Hardy-Weinberg Equilibrium in the patients’ group (p<0.00001). The frequency of the risk allele (allele C) was not significantly different between the patient and control groups (p=0.255). The genotypic distribution between atopic asthma and non-atopic asthma within the patientsts groups was not in agreement with the Hardy-Weinberg Equilibrium (p=0.006). However, risk allele presence showed a statistically significant association with atopy-related asthma (p=0.037).

Discussion & Conclusion: Overall, despite the finding of no association between the 5HTR2C rs6318 C allele and childhood asthma, the current results indicated that there is a strong association between the 5HTR2C rs6318 C variant and childhood atopic asthma.

Keywords

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