FTO |
FTO α-ketoglutarate- dependent dioxygenase |
16q12.2 |
brain, adrenal glands and 25 other tissues |
chimpanzee; rhesus monkey; dog; cow; mouse; rat; chicken; zebrafish; frog |
(exact function of this gene is not known); reversing alkylated DNA and RNA damage by oxidative demethylation |
strong association with BMI, obesity risk and T2DM |
PPARG |
peroxisome proliferator activated receptor γ |
3p25.2 |
biased expression in fat, urinary bladder, colon, stomach and nine other tissues |
chimpanzee; rhesus monkey; dog; cow; mouse; rat; chicken; zebrafish |
helps in regulating transcription of various genes; regulator of adipocyte differentiation |
obsesity, DM, ather oscelrosis, cancer |
ADRB3 |
adrenergic receptor β 3 |
8p11.23 |
ovary, urinary bladder, placenta and two other tissues |
chimpanzee; rhesus monkey; dog; cow; mouse; rat; chicken; zebrafish; frog |
mediate catecholamine-induced activations of adenylate cyclase through the action of G proteins; involved in the regulation of lipolysis and thermogenesis |
obesity and body weight-related disorders |
FABP2 |
fatty acid-binding protein 2 |
4q26 |
small intestine, duodenum, colon |
chimpanzee; rhesus monkey; dog; cow; mouse; rat; chicken; zebrafish; frog |
fatty acid-binding protein, uptake, intracellar metabolism, transport of long-chain fatty acids; may act as a lipid sensor to maintain energy homeostasis |
obesity, kidney diseases, metabolic disorder |