Comparative analysis of genes associated with obesity in humans using bioinformatic data and tools
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27 jul 2021
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Categoría del artículo: Original Article
Publicado en línea: 27 jul 2021
Páginas: 35 - 40
DOI: https://doi.org/10.2478/bjmg-2021-0012
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© 2021 Musliji ZS, Pollozhani AK, Lisichkov K, Deligios M, Popovski ZT, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
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Ontology: comparative data on the four genes/proteins in three species_
| Gene | ||||||
|---|---|---|---|---|---|---|
| Description | Location | Description | Location | Description | Location | |
| chromosome 16; NC_000016.10 (53703963...54121941) | fat mass and obesity associated | chromosome 8; NC_00004.6 (91313367...91668433) | chromosome 11; NC_006098.5 | |||
| peroxisome proliferator activated receptor γ | chromosome 3; NC_000003.12 (12287485...12434344) | perixome proliferator activated receptor γ | chromosome 6; NC_000072.6 (115360879...115490404) | perixome proliferator activated receptor γ | chromosome 12; NC_006099.5 | |
| adrenergic receptor β 3 | chromosome 8; NC_000008.11 (37962990...37966599, complement) | adrenergic receptor β 3 | chromosome 8; NC_00074.6 (27225776...27230845, complement) | adrenergic receptor β 3 | chromosome 22; NC_006109.5 (2551442...2554479, complement) | |
| fatty acid-binding protein 2 | chromosome 4; NC_000004.12 (119317250...119322138, complement) | fatty acid-binding protein 2, intestinal | chromosome 3; NC_000069.6 (122895072...122899506) | fatty acid-binding protein 2 | chromosome 4; NC_006091.5 | |
Data on genetic ontology of the genes (proteins) investigated in this study_
| Symbol | Name | Location | Tissue/Expression | Homologs | Function | Pathology of Diseases |
|---|---|---|---|---|---|---|
| 16q12.2 | brain, adrenal glands and 25 other tissues | chimpanzee; rhesus monkey; dog; cow; mouse; rat; chicken; zebrafish; frog | (exact function of this gene is not known); reversing alkylated DNA and RNA damage by oxidative demethylation | strong association with BMI, obesity risk and T2DM | ||
| peroxisome proliferator activated receptor γ | 3p25.2 | biased expression in fat, urinary bladder, colon, stomach and nine other tissues | chimpanzee; rhesus monkey; dog; cow; mouse; rat; chicken; zebrafish | helps in regulating transcription of various genes; regulator of adipocyte differentiation | obsesity, DM, ather oscelrosis, cancer | |
| adrenergic receptor β 3 | 8p11.23 | ovary, urinary bladder, placenta and two other tissues | chimpanzee; rhesus monkey; dog; cow; mouse; rat; chicken; zebrafish; frog | mediate catecholamine-induced activations of adenylate cyclase through the action of G proteins; involved in the regulation of lipolysis and thermogenesis | obesity and body weight-related disorders | |
| fatty acid-binding protein 2 | 4q26 | small intestine, duodenum, colon | chimpanzee; rhesus monkey; dog; cow; mouse; rat; chicken; zebrafish; frog | fatty acid-binding protein, uptake, intracellar metabolism, transport of long-chain fatty acids; may act as a lipid sensor to maintain energy homeostasis | obesity, kidney diseases, metabolic disorder |