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Mutation status and immunohistochemical correlation of EGFR mutations in gastrointestinal stromal tumors

H Ozkayalar

H Ozkayalar

Department of Pathology, Faculty of Medicine, Near East UniversityNorthern Nicosia, Cyprus
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Ozkayalar, H
, 
MC Ergoren

MC Ergoren

  • Department of Medical Biology, Faculty of Medicine, Near East UniversityNorthern Nicosia, Cyprus
  • Research Center of Experimental Health Sciences (DESAM), Faculty of Medicine, Near East UniversityNorthern Nicosia, Cyprus
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Ergoren, MC
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G Tuncel

G Tuncel

  • Department of Medical Biology, Faculty of Medicine, Near East UniversityNorthern Nicosia, Cyprus
  • Research Center of Experimental Health Sciences (DESAM), Faculty of Medicine, Near East UniversityNorthern Nicosia, Cyprus
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Tuncel, G
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S Kurt

S Kurt

Department of Medical Genetics, Faculty of Medicine, Bursa Uludag UniversityBursa, Turkey
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Kurt, S
, 
E Cevik

E Cevik

Department of Medical Genetics, Faculty of Medicine, Bursa Uludag UniversityBursa, Turkey
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Cevik, E
, 
S Ozemri Sag

S Ozemri Sag

Department of Medical Genetics, Faculty of Medicine, Bursa Uludag UniversityBursa, Turkey
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Ozemri Sag, S
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B Yilmaz Ozguven

B Yilmaz Ozguven

Department of Pathology, Sisli Hamidiye Etfal Education and Research Hospital, University of Health Sciencesİstanbul, Turkey
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Yilmaz Ozguven, B
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F Kabukcuoglu

F Kabukcuoglu

Department of Pathology, Sisli Hamidiye Etfal Education and Research Hospital, University of Health Sciencesİstanbul, Turkey
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Kabukcuoglu, F
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G Mocan

G Mocan

  • Department of Pathology, Faculty of Medicine, Near East UniversityNorthern Nicosia, Cyprus
  • Department of Medical Biology, Faculty of Medicine, Near East UniversityNorthern Nicosia, Cyprus
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Mocan, G
 oraz 
ŞG Temel

ŞG Temel

  • Department of Medical Genetics, Faculty of Medicine, Bursa Uludag UniversityBursa, Turkey
  • Department of Embryology and Histology, Faculty of Medicine, Bursa Uludag UniversityBursa, Turkey
  • Department of Translational Medicine, Bursa Uludag University, Health Sciences InstituteBursa, Turkey
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Temel, ŞG
  
27 lip 2021
Mutation status and immunohistochemical correlation of EGFR mutations in gastrointestinal stromal tumors's Cover Image
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Kategoria artykułu: Original Article
Data publikacji: 27 lip 2021
Zakres stron: 67 - 72
DOI: https://doi.org/10.2478/bjmg-2021-0006
Słowa kluczowe
© 2021 Ozkayalar H, Ergoren MC, Tuncel G, Kurt S, Cevik E, Ozemri Sag S, Yilmaz Ozguven B, Kabukcuoglu F, Mocan G, Temel ŞG, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Images a-d show immunohistochemical staining of GIST samples with spindle-shaped tumor cells, negative for EGFR expression. Images e-f indicate hematoxylin and eosin staining of GIST samples with spindle-shaped tumor cells. Image g represents the positive control, expressing EGFR. All images were taken in 40× magnification. Image h represents the control EGFR sample from a chorionic villus sample.
Images a-d show immunohistochemical staining of GIST samples with spindle-shaped tumor cells, negative for EGFR expression. Images e-f indicate hematoxylin and eosin staining of GIST samples with spindle-shaped tumor cells. Image g represents the positive control, expressing EGFR. All images were taken in 40× magnification. Image h represents the control EGFR sample from a chorionic villus sample.

Patient details such as age, gender, tumor locations, cell types and EGFR gene mutation status are shown_

Sex Mean Age Tumor Location (%) Tumor Cell Type (%) Status of Analyzed EGFR Gene Mutations Exons (codons) EGFR Expression
18 (719) 19 (deletion) 20 (768; 790) 21 (858; 861)
F 57.2±5.6 duodenum (21.5) spindle cell (100.0) wild type wild type wild type wild type negative
ileum (10.5) epithelioid (100.0) wild type wild type wild type wild type negative
small intestine (26.3); epithelioid (20.0);mixed (60.0);spindle cell (20.0) wild type wild type wild type wild type negative
stomach (38.8) spindle cell (57.0);mixed (14.2);epithelioid (28.8) wild type wild type wild type wild type negative
transverse colon (5.2) mixed (100.0) wild type wild type wild type wild type negative
M 62.6±10.5 colon (9.5) spindle cell (100.0) wild type wild type wild type wild type negative
descending colon (4.7) mixed (100.0) wild type wild type wild type wild type negative
duodenum (4.7) spindle cell (100.0) wild type wild type wild type wild type negative
ileum (4.7) mixed (100.0) wild type wild type wild type wild type negative
jejenum (4.7) spindle cell (100.0) wild type wild type wild type wild type negative
small intestine (19.0) spindle cell (25.0);mixed (75.0) wild type wild type wild type wild type negative
Stomach (52.4) spindle cell (54.5);mixed (36.3);epithelioid (9.2) wild type wild type wild type wild type negative
Język:
Angielski
Częstotliwość wydawania:
2 razy w roku
Dziedziny czasopisma:
Medycyna, Podstawowe nauki medyczne, Podstawowe nauki medyczne, inne
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