<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Synonymous mutations in a protein coding gene lead to a remarkably similar average “collateral” mutation effect size across alternative reading frames (1). Here we quantify the rarity of this feature among possible block structure codes as 0.77%. Then we develop a simple model of evolutionary search with two types of mutation. Across different mutation step sizes and ratios of the two types, the fitness-maximizing region corresponds to using a single average mutation value. The analogous constant average collateral mutation effect observed for the standard genetic code may likewise facilitate evolutionary search in alternative frame sequences.</p>
</abstract>

Synonymous mutations in a protein coding gene lead to a remarkably similar average “collateral” mutation effect size across alternative reading frames (1). Here we quantify the rarity of this feature among possible block structure codes as 0.77%. Then we develop a simple model of evolutionary search with two types of mutation. Across different mutation step sizes and ratios of the two types, the fitness-maximizing region corresponds to using a single average mutation value. The analogous constant average collateral mutation effect observed for the standard genetic code may likewise facilitate evolutionary search in alternative frame sequences.

Highly Similar Average Collateral Effect of Synonymous Mutations Across Alternative Reading Frames: A Potential Role In Evolvability

BioCosmos: New perspectives on the origin and evolution of life

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Synonymous mutations in a protein coding gene lead to a remarkably similar average “collateral” mutation effect size across alternative reading frames (1)....

Highly Similar Average Collateral Effect of Synonymous Mutations Across Alternative Reading Frames: A Potential Role In Evolvability

Data publikacji: 17 mar 2023

Zakres stron: 1 - 11

DOI: https://doi.org/10.2478/biocosmos-2023-0001

Słowa kluczowe
genetic code optimality, evolvability, gene origins

© 2023 Stefan Wichmann et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Dodatkowe informacje o materiałach

Highly Similar Average Collateral Effect of Synonymous Mutations Across Alternative Reading Frames: A Potential Role In Evolvability

Data publikacji: 17 mar 2023

Zakres stron: 1 - 11

DOI: https://doi.org/10.2478/biocosmos-2023-0001

Słowa kluczowegenetic code optimality, evolvability, gene origins

© 2023 Stefan Wichmann et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Dodatkowe informacje o materiałach

Słowa kluczowe
genetic code optimality, evolvability, gene origins