Group | Dose (mg/kg) | No. of analysed metaphases | Chromosomal aberrations | TA/500 cells | CA/cell Mean ± SD | |||
---|---|---|---|---|---|---|---|---|
CtB | ChB | CtG | ChG | |||||
NC | 0 | 500 | 18 | 13 | 14 | 15 | 60 | 0.120±0.026 |
PC | 2 | 500 | 106 | 35 | 104 | 60 | 305 | 0.610±0.081 |
1 | 75 | 500 | 21 | 10 | 35 | 15 | 89 | 0.178±0.057 |
2 | 150 | 500 | 20 | 12 | 38 | 10 | 86 | 0.172±0.023 |
3 | 300 | 500 | 27 | 09 | 40 | 16 | 92 | 0.184±0.029 |
NC | 0 | 500 | 14 | 16 | 11 | 17 | 58 | 0.116±0.019 |
PC | 2 | 500 | 102 | 41 | 115 | 53 | 311 | 0.622±0.147 |
1 | 75 | 500 | 20 | 13 | 38 | 12 | 83 | 0.166±0.081 |
2 | 150 | 500 | 15 | 10 | 43 | 10 | 79 | 0.158±0.046 |
3 | 300 | 500 | 19 | 14 | 40 | 11 | 89 | 0.168±0.039 |
NC | 0 | 500 | 15 | 12 | 18 | 16 | 61 | 0.12 ±0.037 |
PC | 2 | 500 | 98 | 35 | 110 | 61 | 304 | 0.608±0.081 |
1 | 5 | 500 | 20 | 13 | 22 | 15 | 70 | 0.140±0.054 |
2 | 10 | 500 | 19 | 14 | 20 | 16 | 69 | 0.138±0.048 |
Nanoparticles | Genotoxicity assay | No of animals | Groups | Dose (mg/kg) |
---|---|---|---|---|
Chromosomal aberration | 15=3 per group | NC | 0 | |
1 | 75 | |||
2 | 150 | |||
3 | 300 | |||
MMC (PC) | 2 | |||
Micronucleus assay | 15=3 per group | NC | 0 | |
1 | 75 | |||
2 | 150 | |||
3 | 300 | |||
MMC (PC) | 2 | |||
Comet assay | 15=3 per group | NC | 0 | |
1 | 75 | |||
2 | 150 | |||
3 | 300 | |||
MMS (PC) | 100 | |||
Chromosomal aberration | 15=3 per group | NC | 0 | |
1 | 75 | |||
2 | 150 | |||
3 | 300 | |||
MMC (PC) | 2 | |||
Micronucleus assay | 15=3 per group | NC | 0 | |
1 | 75 | |||
2 | 150 | |||
3 | 300 | |||
MMC (PC) | 2 | |||
Comet assay | 15=3 per group | NC | 0 | |
1 | 75 | |||
2 | 150 | |||
3 | 300 | |||
MMS (PC) | 100 | |||
Chromosomal aberration | 15=3 per group | NC | 0 | |
1 | 5 | |||
2 | 10 | |||
3 | 15 | |||
MMC (PC) | 2 | |||
Micronucleus assay | 15=3 per group | NC | 0 | |
1 | 5 | |||
2 | 10 | |||
3 | 15 | |||
MMC (PC) | 2 | |||
Comet assay | 15=3 per group | NC | 0 | |
1 | 5 | |||
2 | 10 | |||
3 | 15 | |||
MMS (PC) | 100 |
Group | Dose (mg/kg) | No. of analysed metaphases | No. of mitotic cells | Mitotic index (%) |
---|---|---|---|---|
NC | 0 | 5000 | 409 | 8.180±0.540 |
PC | 2 | 5000 | 61 | 1.220±0.259 |
1 | 75 | 5000 | 399 | 7.980±0.370 |
2 | 150 | 5000 | 395 | 7.900±0.709 |
3 | 300 | 5000 | 401 | 8.080±1.180 |
NC | 0 | 5000 | 417 | 8.340±0.351 |
PC | 2 | 5000 | 58 | 1.160±0.288 |
1 | 75 | 5000 | 403 | 8.060±0.517 |
2 | 150 | 5000 | 409 | 8.180±0.687 |
3 | 300 | 5000 | 399 | 7.980±0.991 |
NC | 0 | 5000 | 411 | 8.220±0.277 |
PC | 2 | 5000 | 54 | 1.080±0.238 |
1 | 5 | 5000 | 406 | 8.120±0.868 |
2 | 10 | 5000 | 399 | 7.980±0.673 |