Anti-inflammatory activity of novel natural plant extracts composition—LevidorTM
, , , , oraz | 22 maj 2023
Article Category: Original Study
Data publikacji: 22 maj 2023
Zakres stron: 49 - 58
Otrzymano: 14 paź 2022
Przyjęty: 21 mar 2023
DOI: https://doi.org/10.2478/ahem-2023-0008
Słowa kluczowe
© 2023 Monika Kuczyńska et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Introduction
Due to the severe side effects of non-steroidal anti-inflammatory drugs, there is an urgent need to find new natural or synthetic chemicals that could act as selective inhibitors of cyclooxygenase-2 (COX-2). The most valuable source of new bioactive compounds and potential drugs are plants. The present study aimed at the investigation of LevidorTM, a patented composition based on oil from the seeds of
Materials and Methods
Studies were carried out with the use of murine macrophages (RAW 264.7), human monocytes (U937), and rat pheochromocytoma (PC-12) cell lines. The cytotoxicity of the LevidorTM extract was evaluated by MTT assay. The concentration of pro-inflammatory cytokines (IL-6, TNF-
Results
The LevidorTM extract did not impact cell growth and showed anti-inflammatory effect in the present study. It was able to decrease the level of IL-6, TNF-
Conclusions
Obtained results showed that LevidorTM exhibits strong anti-inflammatory properties and may provide a significant alternative to traditionally used medicines in acute pain and chronic inflammation.