<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Psoriasis is one of the most common chronic, incurable inflammatory skin diseases, affecting 2–4% of the general population. Etiopathogenesis of this disease remains unclear. It is widely considered to be a multifactorial disorder caused by the interaction between inherited susceptibility alleles and environmental risk factors, such as lifestyle, diet, stimulants, foci of inflammation, and psychological factors. The widespread prevalence of psoriasis is a very significant health and socioeconomic problem. Treatment of psoriasis is based on relieving the acute symptoms of the disease. Despite the implementation of many therapeutic options, including biological treatment, effectiveness of these options is not always sufficient, or in some patients it is not satisfactory. In order to properly control the symptoms of the disease, the patient should be told that the therapeutic effect is achieved not only by pharmacotherapy but also by introducing appropriate healthy habits in everyday life. This article discusses the importance of patient-controlled factors that affect the severity of psoriasis. Theimportance of regular exercise, smoking avoidance, and reduced alcohol consumption is explained, as well as the importance for psoriasis treatment of psychotherapy and spa therapy. Understanding the essence of these factors in the treatment of psoriasis is important in achieving satisfactory therapeutic effects.</p></abstract>

Psoriasis is one of the most common chronic, incurable inflammatory skin diseases, affecting 2–4% of the general population. Etiopathogenesis of this disease remains unclear. It is widely considered to be a multifactorial disorder caused by the interaction between inherited susceptibility alleles and environmental risk factors, such as lifestyle, diet, stimulants, foci of inflammation, and psychological factors. The widespread prevalence of psoriasis is a very significant health and socioeconomic problem. Treatment of psoriasis is based on relieving the acute symptoms of the disease. Despite the implementation of many therapeutic options, including biological treatment, effectiveness of these options is not always sufficient, or in some patients it is not satisfactory. In order to properly control the symptoms of the disease, the patient should be told that the therapeutic effect is achieved not only by pharmacotherapy but also by introducing appropriate healthy habits in everyday life. This article discusses the importance of patient-controlled factors that affect the severity of psoriasis. Theimportance of regular exercise, smoking avoidance, and reduced alcohol consumption is explained, as well as the importance for psoriasis treatment of psychotherapy and spa therapy. Understanding the essence of these factors in the treatment of psoriasis is important in achieving satisfactory therapeutic effects.

Does the lifestyle of patients with psoriasis affect their illness?

Postępy Higieny i Medycyny Doświadczalnej

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Does the lifestyle of patients with psoriasis affect their illness?"}

Psoriasis is one of the most common chronic, incurable inflammatory skin diseases, affecting 2–4% of the general population. Etiopathogenesis of this disease...

	Psoriasis induction mechanism
Alcohol	• Oxidative stress causes lipid peroxidation and a decrease in endogenous antioxidants
	• Increased histamine release → vasodilation → increased migration of inflammatory cells (including mast cells)
	• Increased arachidonic acid concentration
	• Induction of inflammation by increasing CD80 and CD86 expression → increased T cell activation
	• Increase in TNFα and overexpression of TNFα converting enzyme

Cigarettes	• Free radical formation → stimulation of cell signaling pathways, i.e., mitogen-activated protein kinase (MAPK), nuclear factor jB (NF-jB), Janus kinase (JAK), and signal transducer and transcriptional protein activator (JAK-STAT) signal pathway
	• Stimulation of dendritic cells, macrophages, and keratinocytes → release of cytokines, i.e., IL-12, TNF, IL-2 and GM-CSF, which activate lymphocytes T
	• Dioxins bind to the aryl hydrocarbon receptor on Th22 and Th17 lymphocytes → IL-17 and IL-22 productionIncreased expression of HLA-Cw6, HLA-DQA1*0201 and CYP1A1 genes

Does the lifestyle of patients with psoriasis affect their illness?

Article Category: Review

Data publikacji: 29 lis 2021

Zakres stron: 643 - 654

Otrzymano: 28 gru 2020

Przyjęty: 14 cze 2021

DOI: https://doi.org/10.2478/ahem-2021-0033

Słowa kluczowe
psoriasis, psoriatic arthritis, lifestyle, physical effort, smoking, alcohol, spa therapy, psychotherapy

© 2021 Owczarczyk-Saczonek et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

Figure 2

Mechanism of psoriasis induction by alcohol and cigarettes

Does the lifestyle of patients with psoriasis affect their illness?

Article Category: Review

Data publikacji: 29 lis 2021

Zakres stron: 643 - 654

Otrzymano: 28 gru 2020

Przyjęty: 14 cze 2021

DOI: https://doi.org/10.2478/ahem-2021-0033

Słowa kluczowepsoriasis, psoriatic arthritis, lifestyle, physical effort, smoking, alcohol, spa therapy, psychotherapy

© 2021 Owczarczyk-Saczonek et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

Figure 2

Mechanism of psoriasis induction by alcohol and cigarettes

Słowa kluczowe
psoriasis, psoriatic arthritis, lifestyle, physical effort, smoking, alcohol, spa therapy, psychotherapy