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A correlative interaction between thyroid dysfunction and semen parameters in male infertility: A prospective case control study

M. Venkateswara Rao
M. Venkateswara Rao
, 
K. V. N. Geetha Devi
K. V. N. Geetha Devi
, 
D. Rajarajeswari
D. Rajarajeswari
 oraz 
K. Ashalatha
K. Ashalatha
   | 22 gru 2022
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Data publikacji: 22 gru 2022
Zakres stron: 129 - 143
Otrzymano: 18 lip 2022
Przyjęty: 26 sie 2022
DOI: https://doi.org/10.2478/acm-2022-0015
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© 2022 Venkateswara Rao et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig 1

a. ROC of sperm count between the group I and the group II. b. ROC of sperm count levels between the cases with sperm count <28.32 to >28.32. c. ROC of sperm motility levels between the group I and the group II. d. ROC of sperm motility levels between the cases with sperm motility value >40.1, and <40.1. e. ROC of normal morphology levels between the group I and the group II. f. ROC of Normal morphology between the cases with normal morphology value >55.92 and <55.92.
a. ROC of sperm count between the group I and the group II. b. ROC of sperm count levels between the cases with sperm count <28.32 to >28.32. c. ROC of sperm motility levels between the group I and the group II. d. ROC of sperm motility levels between the cases with sperm motility value >40.1, and <40.1. e. ROC of normal morphology levels between the group I and the group II. f. ROC of Normal morphology between the cases with normal morphology value >55.92 and <55.92.

Fig 2

a. ROC of total T3 levels between the group I and the group II. b. ROC of total T3 levels between the cases with total T3 value >1.29 and <1.29. c. ROC of total T4 levels between the group I and the group II. d. ROC of total T4 levels between the cases with total T4 value >8.42 and <8.42 .e. ROC of TSH between the group I and the group II. f. ROC of TSH between the cases with TSH value >1.98 and <1.98.
a. ROC of total T3 levels between the group I and the group II. b. ROC of total T3 levels between the cases with total T3 value >1.29 and <1.29. c. ROC of total T4 levels between the group I and the group II. d. ROC of total T4 levels between the cases with total T4 value >8.42 and <8.42 .e. ROC of TSH between the group I and the group II. f. ROC of TSH between the cases with TSH value >1.98 and <1.98.

ROC analysis showing Area under the ROC Curve (AUC), sensitivity and specificity of different parameters

Parameters AUC Sensitivity Specificity
Group I vs group II
Sperm count 0.7860 87.50 50.80
Total T3 0.5315 50.46 52.31
Normal morphology 0.6390 72.36 42.63
Sperm motility 0.7110 69.85 50
Total T3 0.5030 46.91 54.23
TSH 0.5740 50 57.78
Cases with Sperm motility < 40.1 vs Sperm motility > 40.1
Sperm count 1.000 93.75 68.95
Total T3 0.5882 57.91 50.09
Normal morphology 0.5579 48.35 60.06
Sperm motility 0.5671 57.91 48.03
Total T3 0.6278 58.54 51.96
TSH 0.5570 62.17 44.27

Thyroid status of infertile men

  Euthyroid (n=69) Subclinical hypothyroidism (n=31) P value
Clinical parameters
Suspected hypothyroidism 19 21 -
Obstructive sleep apnoea 8 4 -
Bipolar affective disorders 6 6 -
Headache 3 1 -
Constipation 6 5 -
Speech problems 1 2 -
Semen parameters
Oligospermia 8% 9% 0.40
Asthenozoospermia 7% 6%  
Oligo-asthenoteratospermia 24% 20%  
Total motile sperm count 27.5 ± 19.7 x 106 26.8 ± 18.4 x 106 0.10
Semen volume, mL 2.9 [1.0–3.2] 2.6 [1.2–3.6] 0.45
Sperm motility, % 42.5 [32.9–37.5] 37.2 [30.3–36.1] 0.20
Sperm morphology, % 47.5 [40.2–60.5] 30.5 [28.5–55.5] 0.12
Thyroid profile 1.38 ± 0.44 1.45 ± 0.65 0.25
Total T3(ng/ml) 9.2 ± 1.90 8.66 ± 1.7 0.02*
Total T4 (μg/dl)      
TSH (μIU/ml) 1.89 ± 1.1 2.32 ± 1.5 0.043*

Pearson correlation of Total T3, T4, and TSH levels with semen parameters in infertile men

  Total T3 (ng/ml) Total T4 (μg/dl) TSH (μIU/ml)
  R value P value R value P value R value P value
Semen volume (ml) -0.147 0.22 -0.095 0.430 -0.12 0.02
Sperm count (×106 cells/ml) -0.150 0.32 -0.278 0.020 -0.26 0.22
Sperm motility (%) -0.091 0.42 -0.249 0.032 -0.26 0.02
Morphology (%) -0.079 0.45 0.160 0.130 -0.304 0.02

Comparison of thyroid profile, and risk factors in group I and group II subjects

    Group I Group II
    Ollgozoospermla (n=32) Asthenozoospermla (n=48) Oligo-asthenozoospermia (n=20)
Total T3( ng/ml) Mean ± SD 1.15 ± 0.4 1.29 ± 0.59 1.25 ± 0.32 1.2 ± 0.40
Total T4 (μg/dl) Mean ± SD 7.35 ± 1.42 9.15 ± 1.85* 7.85 ± 1.65 7.2 ± 2.15
TSH (μlU/ml) Mean ± SD 1.69 ± 0.55 2.12 ± 1.45 1.88 ± 0.40 2.1 ± 1.20
BMI- Normal 19 22 11 71
Overweight 8 14 7 21
Obese 5 12 2 8
Varicocele   7 14 6 0
Alcoholic Mild 5 4 4 7
Moderate 3 2 2 2
Heavy 2 1 1 2
Smoker Light Smokers 6 4 4 8
Moderate Smokers 4 2 2 3
Heavy Smokers 2 2 2 2

Comparison of semen and thyroid profile of normal and abnormal subjects

Characteristics   Group I (n=100 Group II (n=100) P value
Age (Years) Mean ± SD 32.4 ± 4.5 31.5 ± 4.8  
Age (yr) 21–25 10% 10% 0.15
26–30 56% 58%
31–35 26% 23%
36–40 8% 9%
Duration of active married life (yr) 2–3 35 34 0.26
3.1–5 33 30
5.1–7 20 18
7.1–9 8 10
9.1–15 4 8
Semen analysis : Quantity (c.c.) <1 2 16 57 2 63 0.0001*
2.1-3 16 15
>3 12 20
Semen analysis : Sperm density (million/ml) >15 48 100 -
10.1 – 15 29 0 -
<10 23 0 -
Semen analysis : Sperm motility Actively motile 32 100 -
Sluggishly motile 40 0 -
Non-motile 28 0 -
Semen analysis : Frequency of motile sperm % >50 22 100 -
20.1-50 48 0 -
5-20 30 0 -
Semen analysis : Pus cell/HPF >10 16 - -
4-10 29 - -
2-3 55 10 -
Sperm count (106/ml) Mean ± SD 28.32 ± 14.60 66.5 ± 10.5 <0.0001*
Sperm motility (%) Mean ± SD 40.1 ± 13.8 64.8 ±7.85 0.0045*0.03
Normal morphology (%) Mean ± SD 55.92 ± 5.27 83.5 ± 5.25 8*
Total T3 (ng/ml) (0.45 – 1.95) Mean ± SD 1.29 ± 0.54 1.15 ± 0.55 0.25
Total T4 (μg/dl) (4.2 – 9.8) Mean ± SD 8.42 ± 1.82* 7.2 ± 3.2 0.02*
TSH (μIU/ml) (0.40 – 5.55) Mean ± SD 1.98 ± 1.3 2.11 ± 1.2 0.14
eISSN:
1338-4139
Język:
Angielski
Częstotliwość wydawania:
3 razy w roku
Dziedziny czasopisma:
Medicine, Clinical Medicine, Internal Medicine, Cardiology
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