<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Infections belong to the most serious health problems in neonates. Invasive candidiases are one of the leading causes of mortality and morbidity in Neonatal intensive care units (NICUs). A more cautious approach is adequate when dealing with fungal infections in premature neonates. Sometimes it is necessary to cure an infection at the very beginning just before manifestation of clinical symptoms. Neonatal colonization due to <italic>Candida albicans</italic> or non-albicans Candidae predisposes to invasive candidiasis. Pregnancies complicated by preterm delivery should be considered for screening and treatment of maternal Candida colonization to decrease the occurrence of neonatal fungal colonization and its consequences. It is important to prevent infection to spread among patients and avoid complications. Prophylaxis in neonates must be safe and effective. Most authors prefer selective prophylaxis. Fluconazole is the drug of choice for prophylaxis in extremely low birth weight (ELBW) neonates. The prophylaxis is beneficial especially in NICUs with high rates of invasive candidiases. The authors describe benefits and trends in prophylaxis. They also summarize evidence on timing, dosing, and effect of fluconazole prophylaxis.</p>
</abstract>

Infections belong to the most serious health problems in neonates. Invasive candidiases are one of the leading causes of mortality and morbidity in Neonatal intensive care units (NICUs). A more cautious approach is adequate when dealing with fungal infections in premature neonates. Sometimes it is necessary to cure an infection at the very beginning just before manifestation of clinical symptoms. Neonatal colonization due to Candida albicans or non-albicans Candidae predisposes to invasive candidiasis. Pregnancies complicated by preterm delivery should be considered for screening and treatment of maternal Candida colonization to decrease the occurrence of neonatal fungal colonization and its consequences. It is important to prevent infection to spread among patients and avoid complications. Prophylaxis in neonates must be safe and effective. Most authors prefer selective prophylaxis. Fluconazole is the drug of choice for prophylaxis in extremely low birth weight (ELBW) neonates. The prophylaxis is beneficial especially in NICUs with high rates of invasive candidiases. The authors describe benefits and trends in prophylaxis. They also summarize evidence on timing, dosing, and effect of fluconazole prophylaxis.

Fluconazole Prophylaxis of Candida Infections in Preterm Neonates

Clinic of Neonatology, Slovak Medical University in Bratislava

Clinic of Neonatology, Jessenius Faculty of Medicine in Martin

Comenius University in Bratislava, and Martin University Hospital

Acta Medica Martiniana

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Fluconazole Prophylaxis of Candida Infections in Preterm Neonates"}

Infections belong to the most serious health problems in neonates. Invasive candidiases are one of the leading causes of mortality and morbidity in Neonatal...

Fluconazole Prophylaxis of Candida Infections in Preterm Neonates

Data publikacji: 05 gru 2019

Zakres stron: 117 - 126

Otrzymano: 29 kwi 2019

Przyjęty: 18 wrz 2019

DOI: https://doi.org/10.2478/acm-2019-0016

Słowa kluczowe
fluconazole, prophylaxis, candida, infection, neonate

© 2019 A Boselova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fluconazole Prophylaxis of Candida Infections in Preterm Neonates

Data publikacji: 05 gru 2019

Zakres stron: 117 - 126

Otrzymano: 29 kwi 2019

Przyjęty: 18 wrz 2019

DOI: https://doi.org/10.2478/acm-2019-0016

Słowa kluczowefluconazole, prophylaxis, candida, infection, neonate

© 2019 A Boselova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Słowa kluczowe
fluconazole, prophylaxis, candida, infection, neonate