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<p>This short overview and updates expresses our brain-and-heart homage to George Emil Palade, “the most influential cell biologist ever”. In his 1971 paper Palade wrote for Albert Claude, the founder of biological electron microscopic method: “Seldom has a field owed so much to a single man”. Herein, we articulate the same words for George Palade, the Teacher of many generations in cell biology research and education. Accordingly, we focus on two paradigm shifts in the cell biology, namely (i) the transition from light to transmission electron microscopy in studying cell protein secretion made by George Palade, and (ii) the transition from contractile to secretory phenotype of vascular smooth muscle cells made by Maria Daria Haust followed and developed by our research group. Altogether, we argue that one of the present challenges in vascular biology is to cultivate secreto-centric thinking and thus further focusing on how we could make the vascular muscle’s secretory pathways work for the benefit of human’s cardiovascular health.</p>
</abstract>

This short overview and updates expresses our brain-and-heart homage to George Emil Palade, “the most influential cell biologist ever”. In his 1971 paper Palade wrote for Albert Claude, the founder of biological electron microscopic method: “Seldom has a field owed so much to a single man”. Herein, we articulate the same words for George Palade, the Teacher of many generations in cell biology research and education. Accordingly, we focus on two paradigm shifts in the cell biology, namely (i) the transition from light to transmission electron microscopy in studying cell protein secretion made by George Palade, and (ii) the transition from contractile to secretory phenotype of vascular smooth muscle cells made by Maria Daria Haust followed and developed by our research group. Altogether, we argue that one of the present challenges in vascular biology is to cultivate secreto-centric thinking and thus further focusing on how we could make the vascular muscle’s secretory pathways work for the benefit of human’s cardiovascular health.

Homage to George E. Palade Cell Protein Secretion in Vascular Biology: Overview and Updates

Department of Anatomy and Cell Biology, and Department of Translational Stem Cell Biology, Research Institute

Department of Pathology, Faculty of Medicine

Department of Hygiene and Epidemiology, Faculty of Public Health

Acta Biologica Marisiensis

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This short overview and updates expresses our brain-and-heart homage to George Emil Palade, “the most influential cell biologist ever”. In his 1971 paper...

Homage to George E. Palade Cell Protein Secretion in Vascular Biology: Overview and Updates

Data publikacji: 01 lip 2021

Zakres stron: 31 - 43

Otrzymano: 15 maj 2021

Przyjęty: 01 cze 2021

DOI: https://doi.org/10.2478/abmj-2021-0004

Słowa kluczowe
George Palade, proteins, secretory pathways, rough endoplasmic reticulum, Golgi complex, microtubules, colchicine, therapy, cardiovascular diseases

© 2021 George N. Chaldakov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Homage to George E. Palade Cell Protein Secretion in Vascular Biology: Overview and Updates

Data publikacji: 01 lip 2021

Zakres stron: 31 - 43

Otrzymano: 15 maj 2021

Przyjęty: 01 cze 2021

DOI: https://doi.org/10.2478/abmj-2021-0004

Słowa kluczoweGeorge Palade, proteins, secretory pathways, rough endoplasmic reticulum, Golgi complex, microtubules, colchicine, therapy, cardiovascular diseases

© 2021 George N. Chaldakov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Słowa kluczowe
George Palade, proteins, secretory pathways, rough endoplasmic reticulum, Golgi complex, microtubules, colchicine, therapy, cardiovascular diseases