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Evaluation of the relationship between ACE2 G8790A and AT2R A1675G gene polymorphisms in COVID-19 patients with and without lung involvement

Raziye Akcilar

Raziye Akcilar

Department of Physiology, Kütahya Health Sciences University, Faculty of MedicineKutahya, Turkey
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Akcilar, Raziye
, 
Fatma Emel Kocak

Fatma Emel Kocak

Department of Medical Biochemistry, Kütahya Health Sciences University, Faculty of MedicineKutahya, Turkey
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Kocak, Fatma Emel
, 
Fatih Kar

Fatih Kar

Department of Basic Sciences, Kütahya Health Sciences University, Faculty of Natural and Engineering SciencesKutahya, Turkey
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Kar, Fatih
, 
Ozben Ozden Isiklar

Ozben Ozden Isiklar

Department of Medical Biochemistry, Kütahya Health Sciences University, Faculty of MedicineKutahya, Turkey
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Isiklar, Ozben Ozden
, 
Sahinde Atlanoglu

Sahinde Atlanoglu

Department of Radiology, Kütahya Health Sciences University, Faculty of MedicineKutahya, Turkey
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Atlanoglu, Sahinde
, 
Ozlem Genc

Ozlem Genc

Department of Medical Microbiology, Kütahya Health Sciences University, Faculty of MedicineKutahya, Turkey
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Genc, Ozlem
 oraz 
Fatima Yaman

Fatima Yaman

Department of Physical Medicine and Rehabilitation, Kütahya Health Sciences University, Faculty of MedicineKutahya, Turkey
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Yaman, Fatima
  
20 wrz 2024
Evaluation of the relationship between ACE2 G8790A and AT2R A1675G gene polymorphisms in COVID-19 patients with and without lung involvement's Cover Image
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Kategoria artykułu: Original article
Data publikacji: 20 wrz 2024
Zakres stron: 157 - 170
DOI: https://doi.org/10.2478/abm-2024-0022
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© 2024 Raziye Akcilar et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Background

The SARS-CoV-2 virus produces severe acute respiratory syndrome. The severity of coronavirus disease 2019 (COVID-19) infection is determined by a number of factors, including inherited ones.

Objectives

Our goal is to investigate the link between ACE2 G8790A (rs2285666) and AT2R A1675G (rs14035430) gene polymorphisms in COVID-19 patients with and without lung involvement.

Methods

A total of 160 COVID-19 patients were divided into 2 groups based on their clinical symptoms: those without lung involvement (control group) and those with lung involvement (infected group). The ACE2 G8790A and AT2R A1675G gene polymorphisms were analyzed using the PCR-RFLP methods.

Results

The GG genotype, G allele of ACE2 G8790A, and GG genotype of AT2R A1675G were significantly higher in the control group and had a protective effect against COVID-19 as well as decreased the development of lung involvement (OR = 0.29, 95% CI = 0.10–0.84; OR = 0.40, 95% CI = 0.22–0.72; and OR = 0.33, 95% CI = 0.14–0.78, respectively). Moreover, we found that the AA genotype, A allele of ACE2 G8790A, and AG genotype of AT2R A1675G increased the risk of COVID-19 in the infected group (OR = 3.50, 95% CI = 1.18–10.3; OR = 2.49, 95% CI = 1.39–4.48; and OR = 3.08, 95% CI = 1.28–7.38, respectively).

Conclusions

These results revealed that a greater frequency of COVID-19 lung involvement in the Turkish population was connected with the AA genotype, the A allele of ACE2 G8790A, and the AG genotype of AT2R A1675G.
Język:
Angielski
Częstotliwość wydawania:
6 razy w roku
Dziedziny czasopisma:
Medycyna, Zawody pomocnicze, pielęgniarstwo, Podstawowe nauki medyczne, Podstawowe nauki medyczne, inne, Medycyna kliniczna, Medycyna kliniczna, inne
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