Characteristics | cCMV-infected infants ( |
Symptomatic infants ( |
Asymptomatic infants ( |
|
---|---|---|---|---|
Maternal age at delivery, (years) | 28 (25–31) | 29 (25–31) | 28 (25–31) | NS |
Primipara, |
42 (45.65) | 33 (45.21) | 9 (47.37) | NS |
Preterm delivery (<37Hbd), |
23 (25.00) | 19 (26.03) | 4 (21.05) | NS |
Caesarean section, |
49 (54.44) | 45 (61.64) | 4 (21.05) | 0.006 |
Prenatal HCMV screening, |
37 (40.22) | 27 (36.99) | 10 (52.63) | NS |
Birth weight, (g) | (21702755 –3200) | (21502685 –3140) | (26803050 –3630) | 0.028 |
Gestational age, (weeks) | 38 (37–39) | 38 (37–39) | 39 (37–40) | NS |
Male, |
46 (50.00) | 36 (49.32) | 10 (52.63) | NS |
Age at admission to NICU, Median (IQR), (days) | 16 (9–23) | 14 (9–21) | 22 (20–35) | <0.001 |
Weight at admission to NICU, (g) | 3040 (2440–3450) | 2980 (2340–3320) | 3600 (2930–4310) | <0.001 |
Age at first HCMV DNA detection in urine, (days) | 9 (4–15) | 8 (3–14) | 17 (8–20) | 0.002 |
SNP,rs number SNP database (dbSNP) reference number (ID number). |
Allele | cCMV-infected infants ( |
Symptomatic infants ( |
Asymptomatic infants ( |
|
---|---|---|---|---|---|
Allele frequencies, |
|||||
IL1B | G | 121 (65.76) | 97 (66.44) | 24 (63.16) | |
rs16944 | NS | ||||
G/A | A | 63 (34.24) | 49 (33.56) | 14 (36.84) | |
IL12B | T | 142 (77.17) | 110 (75.34) | 32 (84.21) | |
rs3212227 | NS | ||||
G/T | G | 42 (22.83) | 36 (24.66) | 6 (15.79) | |
IL28B | C | 120 (65.22) | 92 (63.01) | 28 (73.68) | |
rs12979860 | NS | ||||
C/T | T | 64 (34.78) | 54 (36.99) | 10 (26.32) | |
CCL2 | A | 139 (75.54) | 110 (75.34) | 29 (76.32) | |
rs1024611 | NS | ||||
A/G | G | 45 (24.46) | 36 (24.66) | 9 (23.68) | |
DC-SIGN | G | 107 (58.15) | 87 (59.59) | 20 (52.63) | |
rs735240 | NS | ||||
A/G | A | 77 (41.85) | 59 (40.41) | 18 (47.37) | |
TLR2 | G | 174 (94.57) | 138 (94.52) | 36 (94.74) | |
rs5743708 | NS | ||||
A/G | A | 10 (5.43) | 8 (5.48) | 2 (5.26) | |
TLR4 | C | 175 (95.11) | 139 (95.21) | 36 (94.74) | |
rs4986791 | NS | ||||
C/T | T | 9 (4.89) | 7 (4.79) | 2 (5.26) | |
TLR9 | T | 107 (58.15) | 84 (57.53) | 23 (60.53) | |
rs352140 | NS | ||||
C/T | C | 77 (41.85) | 62 (42.47) | 15 (39.47) |
SNP,rs number SNP database (dbSNP) reference number (ID number). |
Allele | All study population ( |
Uninfected control infants ( |
cCMV-infected infants ( |
Reference population Reference allele frequency based on 1000Genomes study from the Reference SNP (rs) Report. |
||
---|---|---|---|---|---|---|---|
European |
Global |
||||||
Allele frequencies, |
Allele frequencies, % | ||||||
IL1B | G | 320 (68.67) | 199 (70.57) | 121 (65.76) | 65.01 | 49.06 | |
rs16944 | NS | ||||||
G/A | A | 146 (31.33) | 83 (29.43) | 63 (34.24) | 34.99 | 50.94 | |
IL12B | T | 352(75.54) | 210 (74.47) | 142 (77.17) | 77.73 | 64.10 | |
rs3212227 | NS | ||||||
G/T | G | 114 (24.46) | 72 (25.53) | 42 (22.83) | 22.27 | 35.90 | |
IL28B | C | 309 (66.31) | 189 (67.02) | 120 (65.22) | 69.09 | 64.42 | |
rs12979860 | NS | ||||||
C/T | T | 157 (33.69) | 93 (32.98) | 64 (34.78) | 30.91 | 35.58 | |
CCL2 | A | 344 (73.82) | 205 (72.70) | 139 (75.54) | 68.39 | 63.64 | |
rs1024611 | NS | ||||||
A/G | G | 122 (26.18) | 77(27.30) | 45 (24.46) | 31.61 | 36.36 | |
DC-SIGN | G | 278 (59.66) | 171 (60.64) | 107 (58.15) | 56.76 | 64.70 | |
rs735240 | NS | ||||||
A/G | A | 188 (40.34) | 111 (39.36) | 77 (41.85) | 43.24 | 35.30 | |
TLR2 | G | 441 (94.64) | 267 (94.68) | 174 (94.57) | 97.61 | 99.32 | |
rs5743708 | NS | ||||||
A/G | A | 25 (5.36) | 15 (5.32) | 10 (5.43) | 2.39 | 0.68 | |
TLR4 | C | 440 (94.42) | 265 (93.97) | 175 (95.11) | 94.23 | 95.93 | |
rs4986791 | NS | ||||||
C/T | T | 26 (5.58) | 17 (6.03) | 9 (4.89) | 5.77 | 4.07 | |
TLR9 | T | 269 (57.73) | 162 (57.45) | 107 (58.15) | 54.57 | 41.55 | |
rs352140 | NS | ||||||
C/T | C | 197 (42.27) | 120 (42.55) | 77 (41.85) | 45.43 | 58.45 |
Asymptomatic newborn infants with cCMV infection ( |
||||||
---|---|---|---|---|---|---|
SNP, rs number SNP database (dbSNP) reference number (ID number). |
Allele | HCMV DNA (copies/mL) in blood | HCMV DNA (copies/mL) in urine | |||
IL1B | G | 24 (63.16) | 2.0 × 103 (7.5 × 102–3.3 × 103) ( |
4.9 ×105 (1.4 × 105–5.3 × 106) | ||
rs16944 | NS | NS | ||||
G/A | A | 14 (36.84) | 1.8 × 103 (9.9 × 102–2.7 × 104) | 2.4 ×106 (1.7 × 105–6.1 × 106) | ||
IL12B | T | 32 (84.21) | 1.8 × 103 (9.9 × 102–1.5 × 104) ( |
6.9 ×105 (1.4 × 105–5.3 × 106) | ||
rs3212227 | NS | NS | ||||
G/T | G | 6 (15.79) | 2.1 × 103 (0.0–4.0 × 103) | 1.0 ×106 (1.7 × 105–2.0 × 107) | ||
IL28B | C | 28 (73.68) | 2.1 × 103 (6.5 × 102–2.7 × 104) ( |
1.3 ×106 (9.1 × 104–6.1 × 106) | ||
rs12979860 | NS | NS | ||||
C/T | T | 10 (26.32) | 1.2 × 103 (9.9 × 102–2.7 × 103) | 2.9 ×105 (2.5 × 105–2.8 × 106) | ||
CCL2 | A | 29 (76.32) | 1.8 × 103 (9.9 × 102–4.0 × 103) ( |
6.9 ×105 (1.7 × 105–6.1 × 106) | ||
rs1024611 | NS | NS | ||||
A/G | G | 9 (23.68) | 2.4 × 103 (9.5 × 102–1.5 × 104) ( |
2.5 ×105 (1.4 × 105–3.2 × 106) | ||
DC-SIGN | G | 20 (52.63) | 1.2 × 103 (1.5 × 102–3.0 × 103) ( |
4.9 ×105 (1.4 × 105–7.5 × 106) | ||
rs735240 | NS | NS | ||||
A/G | A | 18 (47.37) | 2.1 × 103 (1.2 × 103–3.2 × 104) | 1.3 ×106 (1.7 × 105–4.6 × 106) | ||
TLR2 | G | 36 (94.74) | 2.0 × 103 (6.5 × 102–1.5 × 104) ( |
1.3 ×106 (1.4 × 105–6.1 × 106) | ||
rs5743708 | NS | NS | ||||
A/G | A | 2 (5.26) | 1.4 × 103 (1.2 × 103–1.6 × 103) | 2.3 ×105 (1.7 × 105–2.9 × 105) | ||
TLR4 | C | 36 (94.74) | 2.0 × 103 (9.9 × 102–1.5 × 104) ( |
6.9 ×105 (1.5 × 105–5.3 × 106) | ||
rs4986791 | NS | NS | ||||
C/T | T | 2 (5.26) | 2.0 × 103 (0–4.0 × 103) | 1.0 ×107 (0–2.0 × 107) | ||
TLR9 | T | 23 (60.53) | 1.8 × 103 (1.0 × 103–4.0 × 103) ( |
2.9 ×105 (1.4 × 105–6.1 × 106) | ||
rs352140 | NS | NS | ||||
C/T | C | 15 (39.47) | 2.0 × 103 (3.1 × 102–2.7 × 104) ( |
2.8 ×106 (4.0 × 104–6.1 × 106) |
SNP, rs number SNP database (dbSNP) reference number (ID number). |
Genotype | n = 92, n ( |
HCMV DNA (copies/mL) in blood | HCMV DNA (copies/mL) in urine | ||
---|---|---|---|---|---|---|
IL1B | A/A | 7 (7.6) | 6.3 × 103 (3.8 × 103–2.7 × 104) | 6.5 × 106 (2.8 × 106–1.0 × 107) | ||
rs16944 | A/G | 49 (53.3) | 8.6 × 103 (1.9 × 103–5.8 × 104) ( |
NS | 7.8 × 106 (5.1 × 105–1.0 × 107) ( |
NS |
G/A | G/G | 36 (39.1) | 1.5 × 104 (2.0 × 103–2.0 × 105) ( |
1.0 × 107 (1.7 × 106–1.0 × 107) ( |
||
IL12B | T/T | 57 (62.0) | 2.2 × 104 (2.1 × 103–1.5 × 105) ( |
5.8 × 106 (6.0 × 105–1.0 × 107) ( |
||
rs3212227 | T/G | 28 (30.4) | 7.4 × 103 (1.8 × 103–4.7 × 104) | NS | 1.0 × 107 (6.4 × 106–1.0 × 107) ( |
0.029 |
G/T | G/G | 7 (7.6) | 4.3 × 103 (2.1 × 103–3.0 × 104) | 1.7 × 106 (4.2 × 105–1.0 × 107) | ||
IL28B | T/T | 13 (14.1) | 5.8 × 103 (1.9 × 103–1.3 × 105) ( |
2.8 × 106 (4.0 × 105–1.0 × 107) ( |
||
rs12979860 | T/C | 38 (41.3) | 1.0 × 104 (1.6 × 103–1.3 × 105) | NS | 1.0 × 107 (2.8 × 106–1.0 × 107) ( |
NS |
C/T | C/C | 41 (44.6) | 1.2 × 104 (2.1 × 103–8.2 × 104) ( |
8.6 × 106 (8.4 × 105–1.0 × 107) | ||
CCL2 | G/G | 3 (3.3) | 2.4 × 103 (0–9.4 × 103) | 1.0 × 107 (9.2 × 106–1.0 × 107) | ||
rs1024611 | G/A | 39 (42.4) | 1.7 × 104 (1.7 × 103–5.8 × 104) ( |
NS | 5.5 × 106 (5.2 × 105–1.0 × 107) ( |
NS |
A/G | A/A | 50 (54.3) | 8.9 × 103 (2.4 × 103–1.4 × 105) ( |
8.5 × 106 (1.6 × 106–1.0 × 107) | ||
DC-SIGN | G/G | 35 (38.0) | 1.2 × 104 (1.4 × 103–1.2 × 105) ( |
1.0 × 107 (1.3 × 106–1.0 × 107) | ||
rs735240 | G/A | 37 (40.2) | 1.1 × 104 (2.4 × 103–1.7 × 105) | NS | 7.6 × 106 (1.1 × 106–1.0 × 107) ( |
NS |
A/G | A/A | 20 (21.7) | 7.4 × 103 (1.7 × 103–3.5 × 104) | 5.5 × 106 (5.0 × 105–1.0 × 107) ( |
||
TLR2 | G/G | 82 (89.1) | 1.2 × 104 (2.1 × 103–1.1 × 105) ( |
7.8 × 106 (1.2 × 106–1.0 × 107) ( |
||
rs5743708 | G/A | 10 (10.9) | 4.3 × 103 (1.6 × 103–3.8 × 104) | NS | 1.0 × 107 (1.0 × 106–1.0 × 107) | NS |
A/G | A/A | 0 (0) | NA | NA | ||
TLR4 | T/T | 0 (0) | NA | NA | ||
rs4986791 | T/C | 9 (9.8) | 2.0 × 104 (2.8 × 103–9.8 × 104) | NS | 1.0 × 107 (1.7 × 106–1.0 × 107) | NS |
C/T | C/C | 83 (90.2) | 1.0 × 104 (2.0 × 103–1.0 × 105) ( |
8.6 × 106 (1.1 × 106–1.0 × 107) ( |
||
TLR9 | T/T | 30 (32.6) | 2.4 × 104 (3.6 × 103–2.6 × 105) ( |
1.0 × 107 (1.7 × 106–1.0 × 107) ( |
||
rs352140 | T/C | 47 (51.1) | 8.4 × 103 (2.1 × 103–5.7 × 104) ( |
NS | 5.7 × 106 (8.4 × 105–1.0 × 107) ( |
NS |
C/T | C/C | 15 (16.3) | 7.9 × 103 (1.1 × 103–3.7 × 104) | 1.0 × 107 (1.6 × 106–1.0 × 107) |
Asymptomatic infants with cCMV infection( |
||||||
---|---|---|---|---|---|---|
SNP, rs number SNP database (dbSNP) reference number (ID number). |
Genotype | HCMV DNA (copies/mL) in blood | HCMV DNA (copies/mL) in urine | |||
IL1B | A/A | 2 (10.53) | 1.4 × 104 (9.9 × 102–2.7 × 104) | 5.8 ×106 (2.8 × 106–8.8 × 106) | ||
rs16944 | A/G | 10 (52.63) | 1.8 × 103 (3.1 × 102–4.0 × 103) | NS | 2.7 ×105 (4.0 × 104–3.2 × 106) | NS |
G/A | G/G | 7 (36.84) | 2.0 × 103 (1.2 × 103–2.1 × 103) ( |
6.9 ×105 (1.4 × 105–6.2 × 106) | ||
IL12B | T/T | 14 (73.68) | 1.8 × 103 (1.0 × 103–1.4 × 104) ( |
4.9 × 105 (1.4 × 105–4.6 × 106) | ||
rs3212227 | T/G | 4 (21.05) | 2.0 × 103 (0–3.8 × 105) | NS | 1.1 × 107 (1.0 × 106–4.0 × 107) | NS |
G/T | G/G | 1 (5.26) | 2.1 × 103 (2.1 × 103–2.1 × 103) | 1.7 × 105 (1.7 × 105–1.7 × 105) | ||
IL28B | T/T | 2 (10.53) | 1.9 × 103 (1.2 × 103–2.7 × 103) | 2.7 × 105 (2.5 × 105–2.9 × 105) | ||
rs12979860 | T/C | 6 (31.58) | 1.1 × 103 (0–1.6 × 103) | NS | 2.4× 106 (1.7 × 105–6.2 × 106) | NS |
C/T | C/C | 11 (57.89) | 2.1 × 103 (2.0 × 103–2.7 × 104) ( |
6.9× 105 (4.0 × 104–6.1 × 106) | ||
CCL2 | G/G | 0 (0.00) | NA | NA | ||
rs1024611 | G/A | 9 (47.37) | 2.4 × 103 (9.5 × 102–1.5 × 104) ( |
NS | 2.5× 105 (1.4 × 105–3.2 × 106) | NS |
A/G | A/A | 10 (52.63) | 1.2 × 103 (9.9 × 102–2.1 × 103) ( |
1.7× 106 (1.7 × 105–6.1 × 106) | ||
DC-SIGN | G/G | 7 (36.84) | 3.1 × 102 (0–1.2 × 103) ( |
2.9× 105 (3.3 × 103–2.0 × 107) | ||
rs735240 | G/A | 6 (31.58) | 2.0 × 103 (1.6 × 103–2.7 × 104) | NS | 2.6× 106 (1.7 × 105–6.2 × 106) | NS |
A/G | A/A | 6 (31.58) | 2.4 × 103 (9.9 × 102–3.2 × 104) | 1.1× 106 (4.0 × 104–2.8 × 106) | ||
TLR2 | G/G | 17 (89.47) | 2.1 × 103 (3.1 × 102–2.7 × 104)( |
2.0× 106 (1.4 × 105–6.1 × 106) | ||
rs5743708 | G/A | 2 (10.53) | 1.4 × 103 (1.2 × 103–1.6 × 103) | NS | 2.3× 105 (1.7 × 105–2.9 × 105) | NS |
A/G | A/A | 0 (0.00) | NA | NA | ||
TLR4 | T/T | 0 (0.00) | NA | NA | ||
rs4986791 | T/C | 2 (10.53) | 2.0 × 103 (0–4.0 × 103) | NS | 1.0 × 107 (0–2.0 × 107) | NS |
C/T | C/C | 17 (89.47) | 2.0 × 103 (9.9 × 102–2.7 × 104)( |
6.9× 105 (1.7 × 105–4.6 × 106) | ||
TLR9 | T/T | 7 (36.84) | 1.4 × 103 (0–4.0 × 103) ( |
2.9× 105 (1.4 × 105–2.0 × 107) | ||
rs352140 | T/C | 9 (47.37) | 2.1 × 103 (1.6 × 103–1.7 × 104)( |
NS | 6.9× 105 (1.7 × 105–4.6 × 106) | NS |
C/T | C/C | 3 (15.79) | 3.1× 102 (0–2.7 × 104) | 3.2× 106 (0–8.8 × 106) |
Newborn infants with cCMV infection ( |
||||||
---|---|---|---|---|---|---|
SNP, rs number SNP database (dbSNP) reference number (ID number). |
Allele | HCMV DNA (copies/mL) in blood | HCMV DNA (copies/mL) in urine | |||
IL1B | G | 121 (65.76) | 1.2 × 104 (2.0 × 103–1.7 × 105) ( |
1.0 ×107 (1.1 × 106–1.0 × 107) ( |
||
rs16944 | NS | NS | ||||
G/A | A | 63 (34.24) | 7.6 × 103 (2.4 × 103–3.8 × 104) ( |
6.8 ×106 (1.1 × 106–1.0 × 107) ( |
||
IL12B | T | 142 (77.17) | 1.6 × 104 (2.0 × 103–1.3 × 105) ( |
7.0 ×106 (1.0 × 106–1.0 × 107) ( |
||
rs3212227 | NS | |||||
G/T | G | 42 (22.83) | 4.8 × 103 (2.1 × 103–3.0 × 104) | 1.0 ×107 (1.7 × 106–1.0 × 107) ( |
NS | |
IL28B | C | 120 (65.22) | 1.1 × 104 (2.1 × 103–9.0 × 104) ( |
8.8 ×106 (1.0 × 106–1.0 × 107) ( |
||
rs12979860 | NS | NS | ||||
C/T | T | 64 (34.78) | 8.1 × 103 (1.6 × 103–1.3 × 105) ( |
7.0 ×106 (1.3 × 106–1.0 × 107) ( |
||
CCL2 | A | 139 (75.54) | 1.1 × 104 (2.1 × 103–1.3 × 105) ( |
7.0 ×106 (1.1 × 106–1.0 × 107) ( |
||
rs1024611 | NS | NS | ||||
A/G | G | 45 (24.46) | 1.0 × 104 (1.6 × 103–4.9 × 104) ( |
9.2 ×106 (8.4 × 105–1.0 × 107) ( |
||
DC-SIGN | G | 107 (58.15) | 1.1 × 104 (2.0 × 103–1.3 × 105) ( |
9.6 ×106 (1.3 × 106–1.0 × 107) ( |
||
rs735240 | NS | NS | ||||
A/G | A | 77 (41.85) | 9.4 × 103 (2.1 × 103–5.7 × 104) | 6.1 ×106 (1.0 × 106–1.0 × 107) ( |
||
TLR2 | G | 174 (94.57) | 1.1 × 104 (2.1 × 103–1.0 × 105) ( |
8.6 ×106 (1.1 × 106–1.0 × 107) ( |
||
rs5743708 | NS | NS | ||||
A/G | A | 10 (5.43) | 4.3 × 103 (1.6 × 103–3.8 × 104) | 1.0 ×107 (1.0 × 106–1.0 × 107) | ||
TLR4 | C | 175 (95.11) | 1.0 × 104 (2.1 × 103–9.8 × 104) ( |
8.6 ×106 (1.1 × 106–1.0 × 107) ( |
||
rs4986791 | NS | NS | ||||
C/T | T | 9 (4.89) | 2.0 × 104 (2.8 × 103–9.8 × 104) | 1.0 ×107 (1.7 × 106–1.0 × 107) | ||
TLR9 | T | 107 (58.15) | 1.7 × 103 (2.1 × 103–1.5 × 105) ( |
9.2 ×106 (1.1 × 106–1.0 × 107) ( |
||
rs352140 | NS | NS | ||||
C/T | C | 77 (41.85) | 7.9 × 103 (1.7 × 103–5.1 × 104) ( |
7.8 ×106 (1.0 × 106–1.0 × 107) ( |
SNP, rs number SNP database (dbSNP) reference number (ID number). |
Genotype | cCMV-infected neonates( |
Symptomatic neonates ( |
Asymptomatic neonates ( |
|
---|---|---|---|---|---|
Genotype frequencies, |
|||||
IL1B | A/A | 7 (7.61) | 5 (6.85) | 2 (10.53) | |
rs16944 | A/G | 49 (53.26) | 39 (53.42) | 10 (52.63) | NS |
G/A | G/G | 36 (39.13) | 29 (39.73) | 7 (36.84) | |
IL12B | T/T | 57 (61.96) | 43 (58.90) | 14 (73.68) | |
rs3212227 | T/G | 28 (30.43) | 24 (32.88) | 4 (21.05) | NS |
G/T | G/G | 7 (7.61) | 6 (8.22) | 1 (5.26) | |
IL28B | T/T | 13 (14.13) | 11 (15.07) | 2 (10.53) | |
rs12979860 | T/C | 38 (41.30) | 32 (43.84) | 6 (31.58) | NS |
C/T | C/C | 41 (44.57) | 30 (41.09) | 11 (57.89) | |
CCL2 | G/G | 3 (3.26) | 3 (4.11) | 0 (0.00) | |
rs1024611 | G/A | 39 (42.39) | 30 (41.10) | 9 (47.37) | NS |
A/G | A/A | 50 (54.35) | 40 (54.79) | 10 (52.63) | |
DC-SIGN | G/G | 35 (38.04) | 28 (38.36) | 7 (36.84) | |
rs735240 | G/A | 37 (40.22) | 31 (42.47) | 6 (31.58) | NS |
A/G | A/A | 20 (21.74) | 14 (19.17) | 6 (31.58) | |
TLR2 | G/G | 82 (89.13) | 65 (89.04) | 17 (89.47) | |
rs5743708 | G/A | 10 (10.87) | 8 (10.96) | 2 (10.53) | NS |
A/G | A/A | 0 (0.00) | 0 (0.00) | 0 (0.00) | |
TLR4 | T/T | 0 (0.00) | 0 (0.00) | 0 (0.00) | |
rs4986791 | T/C | 9 (9.78) | 7 (9.59) | 2 (10.53) | NS |
C/T | C/C | 83 (90.22) | 66 (90.41) | 17 (89.47) | |
TLR9 | T/T | 30 (32.61) | 23 (31.51) | 7 (36.84) | |
rs352140 | T/C | 47 (51.09) | 38 (52.05) | 9 (47.37) | NS |
C/T | C/C | 15 (16.30) | 12 (16.44) | 3 (15.79) |
Symptomatic infants with cCMV infection ( |
||||||
---|---|---|---|---|---|---|
SNP rs number SNP database (dbSNP) reference number (ID number). |
Genotype | HCMV DNA (copies/mL) in blood | HCMV DNA (copies/mL) in urine | |||
A/A | 5 (6.85) | 6.3 × 103 (5.4 × 103–1.1 × 104) | 6.5 × 106 (5.4 × 106–1.0 × 107) | |||
IL1B | ||||||
rs16944 | A/G | 39 (53.42) | 1.9 × 104 (3.6 × 103–1.1 × 105) ( |
NS | 1.0 × 107 (1.1 × 106–1.0 × 107) ( |
NS |
G/A | ||||||
G/G | 29 (39.73) | 3.0 × 104 (2.8 × 103–2.1 × 105) | 1.0 × 107 (3.7 × 106–1.0 × 107) ( |
|||
T/T | 43 (58.90) | 3.9 × 104 (5.4 × 103–1.9 × 105) ( |
1.0 × 107 (1.3 × 106–1.0 × 107) ( |
|||
IL12B | ||||||
rs3212227 | T/G | 24 (32.88) | 9.4 × 103 (2.4 × 103–4.7 × 104) | NS | 1.0 × 107 (9.2 × 106–1.0 × 107) ( |
NS |
G/T | ||||||
G/G | 6 (8.22) | 7.9 × 103 (2.4 × 103–3.0 × 104) | 2.3 × 106 (1.6 × 106–1.0 × 107) | |||
T/T | 11 (15.07) | 2.2 × 104 (3.3 × 103–2.1 × 105) ( |
7.0 × 106 (1.3 × 106–1.0 × 107) ( |
|||
IL28B | ||||||
rs12979860 | T/C | 32 (43.84) | 1.9 × 104 (3.2 × 103–1.4 × 105) | NS | 1.0 × 107 (3.5 × 106–1.0 × 107) ( |
NS |
C/T | ||||||
C/C | 30 (41.09) | 1.6 × 104 (3.9 × 103–1.1 × 105) | 1.0 × 107 (1.4 × 106–1.0 × 107) | |||
G/G | 3 (4.11) | 2.4 × 103 (0–9.4 × 103) | 1.0 × 107 (9.2 × 106–1.0 × 107) | |||
CCL2 | ||||||
rs1024611 | G/A | 30 (41.10) | 2.9 × 104 (3.6 × 103–1.1 × 105) | NS | 1.0 × 107 (1.0 × 106–1.0 × 107) ( |
NS |
A/G | ||||||
A/A | 40 (54.79) | 1.2 × 104 (3.9 × 103–2.0 × 105) ( |
1.0 × 107 (3.7 × 106–1.0 × 107) | |||
G/G | 28 (38.36) | 2.9 × 104 (4.3 × 103–1.5 × 105) ( |
1.0 × 107 (4.2 × 106–1.0 × 107) | |||
DC-SIGN | ||||||
rs735240 | G/A | 31 (42.47) | 1.2 × 104 (3.6 × 103–1.9 × 105) | NS | 1.0 × 107 (1.4 × 106–1.0 × 107) ( |
NS |
A/G | ||||||
A/A | 14(19.17) | 1.3 × 104 (2.8 × 103–3.8 × 104) | 1.0 × 107 (1.7 × 106–1.0 × 107) ( |
|||
G/G | 65 (89.04) | 1.9 × 104 (3.7 × 103–1.7 × 105) ( |
1.0 × 107 (1.7 × 106–1.0 × 107) ( |
|||
TLR2 | ||||||
rs5743708 | G/A | 8 (10.96) | 5.0 × 103 (2.8 × 103–8.4 × 104) | NS | 1.0 × 107 (5.5 × 106–1.0 × 107) | NS |
A/G | ||||||
A/A | 0 (0.00) | NA | NA | |||
T/T | 0 (0.00) | NA | NA | |||
TLR4 | ||||||
rs4986791 | T/C | 7 (9.59) | 3.8 × 104 (2.8 × 103–1.1 × 105) | NS | 1.0 × 107 (1.7 × 106–1.0 × 107) | NS |
C/T | ||||||
C/C | 66 (9×0.41) | 1.4 × 104 (3.8 × 103–1.5 × 105) ( |
1.0 × 107 (1.7 × 106–1.0 × 107) ( |
|||
TLR9 | T/T | 23 (31.51) | 2.9 × 104 (5.3 × 103–2.6 × 105) | 1.0 × 107 (5.5 × 106–1.0 × 107) ( |
||
rs352140 | T/C | 38 (52.05) | 1.4 × 104 (2.8 × 103–8.2 × 104) ( |
NS | 1.0 × 107 (1.1 × 106–1.0 × 107) ( |
NS |
C/T | C/C | 12 (16.44) | 8.6 × 103 (3.0 × 103–4.7 × 104) | 1.0 × 107 (4.3 × 106–1.0 × 107) |
Symptomatic newborn infants with cCMV infection ( |
||||||
---|---|---|---|---|---|---|
SNP, rs number SNP database (dbSNP) reference number (ID number). |
Allele | Alleles, |
HCMV (copies/DNA mL) in blood | HCMV DNA (copies/mL) in urine | ||
IL1B | G | 97 (66.44) | 2.2 × 104 (3.0 × 103–1.9 × 105) ( |
1.0 × 107 (2.9 × 106–1.0 × 107) ( |
||
rs16944 | NS | NS | ||||
G/A | A | 49 (33.56) | 1.1 × 104 (3.8 × 103–5.4 × 104) ( |
1.0 × 107 (1.5 × 106–1.0 × 107) ( |
||
IL12B | T | 110 (75.34) | 2.6 × 104 (4.7 × 103–1.8 × 105) | 1.0 × 107 (1.4 × 106–1.0 × 107) | ||
rs3212227 | ( |
0.037 | ( |
NS | ||
G/T | G | 36 (24.66) | 9.4 × 103 (2.4 × 103–3.4 × 104) | 1.0 × 107 (1.7 × 106–1.0 × 107) ( |
||
IL28B | C | 92 (63.01) | 1.7 × 104 (3.8 × 103–1.2 × 105) | 1.0 × 107 (1.7 × 106–1.0 × 107) ( |
||
rs12979860 | NS | NS | ||||
C/T | T | 54 (36.99) | 1.9 × 104 (3.3 × 103–1.8 × 105) ( |
1.0 × 107 (1.6 × 106–1.0 × 107) ( |
||
CCL2 | A | 110 (75.34) | 1.9 × 104 (3.9 × 103–1.7 × 105) | 1.0 × 107 (1.7 × 106–1.0 × 107) | ||
rs1024611 | ( |
NS | ( |
NS | ||
A/G | G | 36 (24.66) | 1.6 × 104 (2.0 × 103–5.4 × 104) | 1.0 × 107 (1.4 × 106–1.0 × 107) ( |
||
DC-SIGN | G | 87 (59.59) | 2.8 × 104 (3.9 × 103–1.5 × 105) ( |
1.0 × 107 (2.9 × 106–1.0 × 107) ( |
||
rs735240 | NS | NS | ||||
A/G | A | 59 (40.41) | 1.2 × 104 (3.3 × 103–8.2 × 104) | 1.0 × 107 (1.5 × 106–1.0 × 107) ( |
||
TLR2 | G | 138 (94.52) | 1.7 × 104 (3.7 × 103–1.5 × 105) | 1.0 × 107 (1.7 × 106–1.0 × 107) | ||
rs5743708 | ( |
NS | ( |
NS | ||
A/G | A | 8 (5.48) | 5.0 × 103 (2.8 × 103–8.4 × 104) | 1.0 × 107 (5.5 × 106–1.0 × 107) | ||
TLR4 rs4986791 | C | 139 (95.21) | 1.7 × 104 (3.8 × 103–1.5 × 105) ( |
NS | 1.0 × 107 (1.7 × 106–1.0 × 107) ( |
NS |
C/T | T | 7 (4.79) | 3.8 × 104 (2.8 × 103–1.1 × 105) | 1.0 × 107 (1.7 × 106–1.0 × 107) | ||
TLR9 | T | 84 (57.53) | 2.8 × 104 (3.8 × 103–1.9 × 105) ( |
1.0 × 107 (2.9 × 106–1.0 × 107) ( |
||
rs352140 | NS | NS | ||||
C/T | C | 62 (42.47) | 9.4 × 103 (2.8 × 103–5.8 × 104) ( |
1.0 × 107 (1.6 × 106–1.0 × 107) ( |