<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_raon-2018-0001_s_006_w2aab3b7c12b1b6b1aab1c18b1Aa"><h3>Background</h3><p>The aim of the study was to examine the value of quantitative and qualitative MRI and <sup>11</sup>C acetate PET/CT parameters in predicting regional lymph node (LN) metastasis of newly diagnosed prostate cancer (PCa).</p></sec><sec id="j_raon-2018-0001_s_007_w2aab3b7c12b1b6b1aab1c18b2Aa"><h3>Patients and methods</h3><p>Patients with intermediate (n = 6) and high risk (n = 47) PCa underwent 3T MRI (40 patients) and <sup>11</sup>C acetate PET/CT (53 patients) before extended pelvic LN dissection. For each patient the visually most suspicious LN was assessed for mean apparent diffusion coefficient (ADCmean), maximal standardized uptake value (SUVmax), size and shape and the primary tumour for T stage on MRI and ADCmean and SUVmax in the index lesion. The variables were analysed in simple and multiple logistic regression analysis.</p></sec><sec id="j_raon-2018-0001_s_008_w2aab3b7c12b1b6b1aab1c18b3Aa"><h3>Results</h3><p>All variables, except ADCmean and SUVmax of the primary tumor, were independent predictors of LN metastasis. In multiple logistic regression analysis the best model was ADCmean in combintion with MRI T-stage where both were independent predictors of LN metastasis, this combination had an AUC of 0.81 which was higher than the AUC of 0.65 for LN ADCmean alone and the AUC of 0.69 for MRI T-stage alone.</p></sec><sec id="j_raon-2018-0001_s_009_w2aab3b7c12b1b6b1aab1c18b4Aa"><h3>Conclusions</h3><p>Several quantitative and qualitative imaging parameters are predictive of regional LN metastasis in PCa. The combination of ADCmean in lymph nodes and T-stage on MRI was the best model in multiple logistic regression with increased predictive value compared to lymph node ADCmean and T-stage on MRI alone.</p></sec></abstract>

BackgroundThe aim of the study was to examine the value of quantitative and qualitative MRI and 11C acetate PET/CT parameters in predicting regional lymph node (LN) metastasis of newly diagnosed prostate cancer (PCa).Patients and methodsPatients with intermediate (n = 6) and high risk (n = 47) PCa underwent 3T MRI (40 patients) and 11C acetate PET/CT (53 patients) before extended pelvic LN dissection. For each patient the visually most suspicious LN was assessed for mean apparent diffusion coefficient (ADCmean), maximal standardized uptake value (SUVmax), size and shape and the primary tumour for T stage on MRI and ADCmean and SUVmax in the index lesion. The variables were analysed in simple and multiple logistic regression analysis.ResultsAll variables, except ADCmean and SUVmax of the primary tumor, were independent predictors of LN metastasis. In multiple logistic regression analysis the best model was ADCmean in combintion with MRI T-stage where both were independent predictors of LN metastasis, this combination had an AUC of 0.81 which was higher than the AUC of 0.65 for LN ADCmean alone and the AUC of 0.69 for MRI T-stage alone.ConclusionsSeveral quantitative and qualitative imaging parameters are predictive of regional LN metastasis in PCa. The combination of ADCmean in lymph nodes and T-stage on MRI was the best model in multiple logistic regression with increased predictive value compared to lymph node ADCmean and T-stage on MRI alone.

MRI and <sup>11</sup>C acetate PET/CT for prediction of regional lymph node metastasis in newly diagnosed prostate cancer

Department of Surgical Sciences/Radiology

Radiology and Oncology

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

MRI and C acetate PET/CT for prediction of regional lymph node metastasis in newly diagnosed prostate cancer

BackgroundThe aim of the study was to examine the value of quantitative and qualitative MRI and 11C acetate PET/CT parameters in predicting regional lymph node...

MRI and ¹¹C acetate PET/CT for prediction of regional lymph node metastasis in newly diagnosed prostate cancer

Article Category: Research Article

Pubblicato online: 24 gen 2018

Pagine: 90 - 97

Ricevuto: 31 ago 2017

Accettato: 15 nov 2017

DOI: https://doi.org/10.2478/raon-2018-0001

© 2018 Catrin von Below, Cecilia Wassberg, Rafael Grzegorek, Joel Kullberg, Charlotta Gestblom, Jens Sörensen, Mauritz Waldén, Håkan Ahlström

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

MRI and 11C acetate PET/CT for prediction of regional lymph node metastasis in newly diagnosed prostate cancer

Article Category: Research Article

Pubblicato online: 24 gen 2018

Pagine: 90 - 97

Ricevuto: 31 ago 2017

Accettato: 15 nov 2017

DOI: https://doi.org/10.2478/raon-2018-0001

© 2018 Catrin von Below, Cecilia Wassberg, Rafael Grzegorek, Joel Kullberg, Charlotta Gestblom, Jens Sörensen, Mauritz Waldén, Håkan Ahlström

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

MRI and ¹¹C acetate PET/CT for prediction of regional lymph node metastasis in newly diagnosed prostate cancer