Accesso libero

MRI and 11C acetate PET/CT for prediction of regional lymph node metastasis in newly diagnosed prostate cancer

Catrin von Below
Catrin von Below
, 
Cecilia Wassberg
Cecilia Wassberg
, 
Rafael Grzegorek
Rafael Grzegorek
, 
Joel Kullberg
Joel Kullberg
, 
Charlotta Gestblom
Charlotta Gestblom
, 
Jens Sörensen
Jens Sörensen
, 
Mauritz Waldén
Mauritz Waldén
 e 
Håkan Ahlström
Håkan Ahlström
   | 24 gen 2018
Radiology and Oncology's Cover Image
INFORMAZIONI SU QUESTO ARTICOLO
Articolo precedente
Articolo Successivo
Cita
Article Category: Research Article
Pubblicato online: 24 gen 2018
Pagine: 90 - 97
Ricevuto: 31 ago 2017
Accettato: 15 nov 2017
DOI: https://doi.org/10.2478/raon-2018-0001
© 2018 Catrin von Below, Cecilia Wassberg, Rafael Grzegorek, Joel Kullberg, Charlotta Gestblom, Jens Sörensen, Mauritz Waldén, Håkan Ahlström
This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

MRI DWI and 11C Acetate PET/CT variables dichotomized with ROC curve and analyzed with multiple logistic regression

Model

Model one through ten: presented with OR (95%CI), p-value.

M1M2M3M4M5M6M7M8M9M10
3.74.18.42.7
LN-ADCmean 10-6 mm2 /s(1.1–13.3),(1.1–14.7),(1.8–39.0),(0.8–9.5),
0.0400.0320.0070.110
5.62.74.72.3
LN-SUVmax(1.5–20.6),(0.6-11.1),(1.1-20.5),(0.5-10.7),
0.0100.1790.0400.30
5.73.76.22.8
LN-shape(1.5–21.2),(0.9–15.0),(1.4–27.2),(0.5–14.7),
0.0100.0690.0160.226
6.85.33.94.5
MRI T-stage T3b

T3a is not presented in the table, this is because it is not significant in any of the ten models above.

 / ≤ T2		(1.1–41.6),(1.0–28.6),(0.7–22.0),(0.8–25.2),
0.0390.0510.1260.083
7.54.83.89.3
LN-size mm(1.4–40.3),(0.7-34.7),(0.4-31.6),(1.4-61.1),
0.0180.116)0.2240.020

Nagelkerke’s R2

Psedo R2		0.270.300.390.260.240.290.220.330.230.34
AUC0.750.760.810.730.710.750.680.790.710.75
Sensitivity72746783636568747474
Specificity68687765667265836873
PPV52568040607552855670
NPV83826293686279718276
Cramers’V

Multicollinearity

0.090.150.160.250.540.280.660.370.720.34
Accuracy69707169646866787073

Investigational findings at MRI DWI and 11C Acetate PET/CT

MRI DWI and 11C Acetate PET/CT findings
LN-ADCmean 10-6 mm2 /s, mean (SD) range917 (191) 582–1398
LN-SUVmax, mean (SD) range1.8 (1.2) 0.7–5.9
LN size mm, mean (SD) range6.6 (3.7) 3.8–28.3
Proportion of LNs with round shape, n19
Proportion of LNs with oval shape, n34
MRI T-stage, n
< T325
T3a14
T3b14
LN ADC Roi size mm2, median (range)42 (16–334)
Tumor ADC Roi size mm2≥ 80

MRI DWI and 11C Acetate PET/CT variables dichotomized using ROC curve and analyzed with simple logistic regression

N0 nN1 nOR95%CIp-valueThresholdAUCPseudo R2

Nagelkerke’s R2

Sensitivity/Specificity/PPV/NPV
LN-ADCmean 10-6 mm2 /s21193.61.1-11.60.031 ≤ 8000.650.1258/73/76/53
LN-SUVmax28255.41.6-18.70.008≥ 1.60.680.1872/68/52/83
LN-size mm28258.71.7–44.90.010≥ 7.90.660.2083/63/40/93
LN round shape5145.91.7-20.40.0060.690.2074/68/56/82
LN oval shape2311refrefrefrefrefrefref
MRI-T-stage
≤ T2187refrefrefrefrefrefref
T3a772.000.4-10.50.412
T3b3116.01.2-29.40.0270.690.1765/67/65/67

Patient characteristics

Patient characteristics
Patients, n53
Age, median (range)68 (55–76)
LN positive patients, n26
PSA level ng/ml, mean (median, range)24 (19, 3–112)
Biopsy Gleason score, n (%)
65 (9.4)
739 (73.6)
85 (9.4)
94 (7.5)
D’Amico risk classification, n (%)
Intermediate6 (11.3)
High47 (88.7)
Clincal T-stage, n (%)
T1c1 (1.9)
T211 (20.8)
T341 (77.4)
Risk of LN invasion

Calculated according to Briganti nomogram (26)

, n
19–59%27
≥ 60%26
eISSN:
1581-3207
Lingua:
Inglese
Frequenza di pubblicazione:
4 volte all'anno
Argomenti della rivista:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology
Feed RSS della rivista