<abstract xmlns="http://www.w3.org/1999/xhtml">

<italic>Candida</italic> spp. is the most prevalent cause of fungal infection worldwide, and their increasing resistance to anti-fungal agents, especially to azoles, has become problematic. The aim of this work was to establish the susceptibility to fluconazole, itraconazole, voriconazole and posaconazole of 50 clinical <italic>C. albicans</italic> isolates from hematooncological patients. This has been evaluated using the following parameters: MIC (Minimum Inhibitory Concentration), MIC50 (MIC required to inhibit the growth of 50% of organisms), as well as MIC90 (MIC required to inhibit the growth of 90% of organisms). Susceptibility of the studied clinical isolates to all azoles was high, being 86% for itraconazole, 90% for fluconazole and posaconazole and 92% for voriconazole. The resistance rates ranged from 8% (voriconazole), to 12% (itraconazole). The emergence of azole-resistant yeast strains creates a necessity to determine and monitor the sensitivity of the isolated <italic>Candida</italic> spp., including <italic>C. albicans</italic>, especially in patients predisposed to life-threating fungal invasive disease.
</abstract>

Candida spp. is the most prevalent cause of fungal infection worldwide, and their increasing resistance to anti-fungal agents, especially to azoles, has become problematic. The aim of this work was to establish the susceptibility to fluconazole, itraconazole, voriconazole and posaconazole of 50 clinical C. albicans isolates from hematooncological patients. This has been evaluated using the following parameters: MIC (Minimum Inhibitory Concentration), MIC50 (MIC required to inhibit the growth of 50% of organisms), as well as MIC90 (MIC required to inhibit the growth of 90% of organisms). Susceptibility of the studied clinical isolates to all azoles was high, being 86% for itraconazole, 90% for fluconazole and posaconazole and 92% for voriconazole. The resistance rates ranged from 8% (voriconazole), to 12% (itraconazole). The emergence of azole-resistant yeast strains creates a necessity to determine and monitor the sensitivity of the isolated Candida spp., including C. albicans, especially in patients predisposed to life-threating fungal invasive disease.

Susceptibility <italic>in vitro</italic> of clinical <italic>Candida albicans</italic> isolates to the selected azoles

Department of Pharmaceutical Microbiology

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Susceptibility  of clinical  isolates to the selected azoles

Candida spp. is the most prevalent cause of fungal infection worldwide, and their increasing resistance to anti-fungal agents, especially to azoles, has become...

Susceptibility in vitro of clinical Candida albicans isolates to the selected azoles

Pubblicato online: 15 lug 2021

Pagine: 77 - 80

Ricevuto: 14 feb 2021

Accettato: 15 mag 2021

DOI: https://doi.org/10.2478/cipms-2021-0015

Parole chiave
hematooncological patients, azoles, resistance

© 2021 Bartlomiej Pawlicki et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Susceptibility in vitro of clinical Candida albicans isolates to the selected azoles

Pubblicato online: 15 lug 2021

Pagine: 77 - 80

Ricevuto: 14 feb 2021

Accettato: 15 mag 2021

DOI: https://doi.org/10.2478/cipms-2021-0015

Parole chiavehematooncological patients, azoles, resistance

© 2021 Bartlomiej Pawlicki et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Parole chiave
hematooncological patients, azoles, resistance