<abstract xmlns="http://www.w3.org/1999/xhtml">

<italic>Candida</italic> spp. is the most prevalent cause of fungal infection worldwide, and their increasing resistance to anti-fungal agents, especially to azoles, has become problematic. The aim of this work was to establish the susceptibility to fluconazole, itraconazole, voriconazole and posaconazole of 50 clinical <italic>C. albicans</italic> isolates from hematooncological patients. This has been evaluated using the following parameters: MIC (Minimum Inhibitory Concentration), MIC50 (MIC required to inhibit the growth of 50% of organisms), as well as MIC90 (MIC required to inhibit the growth of 90% of organisms). Susceptibility of the studied clinical isolates to all azoles was high, being 86% for itraconazole, 90% for fluconazole and posaconazole and 92% for voriconazole. The resistance rates ranged from 8% (voriconazole), to 12% (itraconazole). The emergence of azole-resistant yeast strains creates a necessity to determine and monitor the sensitivity of the isolated <italic>Candida</italic> spp., including <italic>C. albicans</italic>, especially in patients predisposed to life-threating fungal invasive disease.
</abstract>

Candida spp. is the most prevalent cause of fungal infection worldwide, and their increasing resistance to anti-fungal agents, especially to azoles, has become problematic. The aim of this work was to establish the susceptibility to fluconazole, itraconazole, voriconazole and posaconazole of 50 clinical C. albicans isolates from hematooncological patients. This has been evaluated using the following parameters: MIC (Minimum Inhibitory Concentration), MIC50 (MIC required to inhibit the growth of 50% of organisms), as well as MIC90 (MIC required to inhibit the growth of 90% of organisms). Susceptibility of the studied clinical isolates to all azoles was high, being 86% for itraconazole, 90% for fluconazole and posaconazole and 92% for voriconazole. The resistance rates ranged from 8% (voriconazole), to 12% (itraconazole). The emergence of azole-resistant yeast strains creates a necessity to determine and monitor the sensitivity of the isolated Candida spp., including C. albicans, especially in patients predisposed to life-threating fungal invasive disease.

Susceptibility <italic>in vitro</italic> of clinical <italic>Candida albicans</italic> isolates to the selected azoles

Department of Pharmaceutical Microbiology

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Susceptibility  of clinical  isolates to the selected azoles

Candida spp. is the most prevalent cause of fungal infection worldwide, and their increasing resistance to anti-fungal agents, especially to azoles, has become...

Susceptibility in vitro of clinical Candida albicans isolates to the selected azoles

Published Online: Jul 15, 2021

Page range: 77 - 80

Received: Feb 14, 2021

Accepted: May 15, 2021

DOI: https://doi.org/10.2478/cipms-2021-0015

Keywords
hematooncological patients, azoles, resistance

© 2021 Bartlomiej Pawlicki et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Susceptibility in vitro of clinical Candida albicans isolates to the selected azoles

Published Online: Jul 15, 2021

Page range: 77 - 80

Received: Feb 14, 2021

Accepted: May 15, 2021

DOI: https://doi.org/10.2478/cipms-2021-0015

Keywordshematooncological patients, azoles, resistance

© 2021 Bartlomiej Pawlicki et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
hematooncological patients, azoles, resistance