The widespread prevalence of food pollutants seriously threatens human and animal health. Mycotoxins are secondary metabolites primarily formed by toxigenic fungal genera, including Aspergillus, Penicillium, Fusarium, and Alternaria, demonstrating one of the principal pollutants in diets or feed products. Mycotoxin contamination in food can harm health, including stunted development, immune system suppression, infertility, vomiting, and gastrointestinal and cancerous conditions. These effects can occur both acutely and chronically. The complex food chain can be contaminated with mycotoxins at any point, including during harvest, industrial processing, shipping, or storage, putting the food sector under societal pressure owing to the waste generated by infected goods. One of the biological controls of mycotoxin is provided by probiotics and prebiotics, controlled as foods and dietary supplements made of bacteria or yeast. Aflatoxin’s bioavailability and gastrointestinal absorption can be reduced using various probiotics and prebiotics.