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The functional role of miRNAs in inflammatory pathways associated with intestinal epithelial tight junction barrier regulation in IBD

Błażej Ochman
Błażej Ochman
, 
Agnieszka Kula
Agnieszka Kula
 e 
Elżbieta Świętochowska
Elżbieta Świętochowska
   | 29 giu 2022
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Article Category: Review
Pubblicato online: 29 giu 2022
Pagine: 254 - 267
Ricevuto: 18 ago 2021
Accettato: 28 dic 2021
DOI: https://doi.org/10.2478/ahem-2022-0038
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© 2022 Błażej Ochman et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1

Mechanism of action of miRNA-based drugs in IBD. The left side demonstrates the molecular effect of altered miRNAs’ expression in IBD. The right side shows miRNA-based treatment response. miRNA–microRNA; TJs–tight junctions; IEB–intestinal epithelial barrier
Mechanism of action of miRNA-based drugs in IBD. The left side demonstrates the molecular effect of altered miRNAs’ expression in IBD. The right side shows miRNA-based treatment response. miRNA–microRNA; TJs–tight junctions; IEB–intestinal epithelial barrier

MiRNAs collected in this review with their targets, marked expression in IBD, and altered TJ proteins expression. The table was divided into in vivo and in vitro examined effects on TJ proteins expression induced by altered miRNA expression; miRNA–microRNA; ZO-1–Zonula occludens-1; CLDN–Claudin; JAM-A–junctional adhesion molecules A; AJ–adherent junction; CD–-Crohn's disease; UC–-ulcerative colitis; IBD–inflammatory bowel disease; PBMCs–peripheral blood mononuclear cells

microRNA Target mRNA Expression in IBD TJ proteins expression associated with miRNA-induced effect Author/year
In vivo observed effects
miRNA-124a Aryl hydrocarbon receptor (AhR) Overexpression in CD tissue ZO-1 ↓, OCLN ↓, JAM-A ↓, CLDN1 ↓ Zhao et al., 2020 [58]
miRNA-31-5p Activin receptor-like type 1 (ALK1) Overexpression in CD tissue CLDN8 ↓, TJP1 ↓, OCLN ↓ Toyonaga et al., 2020 [39]
miRNA-301A B-cell translocation gene 1 (BTG1) Overexpression in PBMCs and tissue in IBD E-cadherin (AJ) ↓ He et al., 2017 [86]
miRNA-200b Myosin light chain kinase (MLCK) and c-JUN Decreased in IBD tissue ZO-1 ↓, OCLN ↓ Shen et al., 2017 [64]
miRNA-21 Claudin 8 (CLDN8) Overexpression in CD tissue CLDN8 ↓ Li et al., 2018 [71]
miRNA-200c-3p Occludin (OCLN) Overexpression in UC tissue OCLN ↓ Rawat et al., 2020 [81]
miRNA-495 Signal transducer and activator of transcription 3 (STAT3) Decreased in UC tissue CLDN1 ↓ Chu et al., 2018 [90]
miRNA-122a Epidermal growth factor receptor (EGFR) Overexpression in IBD tissue CLDN1 ↓, OCLN ↓, Zonulin ↑ Zhang et al., 2017 [92]
miRNA-320a Protein phosphatase 2 (PP2A) and Cell division cycle 42 (Cdc42) Overexpression in serum of active CD JAM-A ↑ Cordes et al., 2016 [106]
miRNA-423-5p CLDN5 Overexpression in UC tissue CLDN5 ↓ Wang et al., 2020 [77]
In vitro observed effects
miRNA-185-3p Myosin light chain kinase (MLCK) Decreased in IBD tissue ZO-1 ↓, OCLN ↓ Ma et al., 2019 [63]
miRNA-23a Tumor necrosis factor alpha inhibitor protein 3 (TNFAIP3) Overexpression in CD tissue OCLN destabilization Felwick et al., 2020 [33]
miRNA-675-5p Vitamin D receptor (VDR) Overexpression in UC tissue ZO-1 ↓, OCLN ↓ Chen et al., 2016 [52]
miRNA-375 Toll-like receptor 4 (TLR4) Decreased in IBD tissue ZO-1 ↓, OCLN ↓ Wu et al., 2019 [98]
miRNA-223 Claudin 8 (CLDN8) Overexpression in IBD tissue CLDN8 ↓ Wang et al., 2016 [68]
eISSN:
1732-2693
Lingua:
Inglese
Frequenza di pubblicazione:
Volume Open
Argomenti della rivista:
Life Sciences, Molecular Biology, Microbiology and Virology, Medicine, Basic Medical Science, Immunology
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