<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Inflammatory bowel disease – Crohn's disease and ulcerative colitis – is an immune-mediated chronic disorder with still not fully elucidated complex mechanisms of pathogenesis and pathophysiology. Intestinal epithelial barrier (IEB) dysregulation is one of the major underlying mechanisms of inflammatory process induction in IBD. Proper IEB integrity is maintained to a large extent by intercellular tight junctions, the function of which can be modified by many molecules, including miRNAs. MiRNAs belong to noncoding and non-messenger RNAs, which can modulate gene expression by binding predicted mRNAs.</p>
<p>In this review, we summarize and discuss the potential role of miRNAs in the regulation of inflammatory signaling pathways affecting the function of the intestinal epithelial barrier in IBD, with particular emphasis on therapeutic potentials. The aim of the review is also to determine the further development directions of the studies on miRNA in the modulation of the intestinal epithelial barrier in IBD.</p>
</abstract>

Inflammatory bowel disease – Crohn's disease and ulcerative colitis – is an immune-mediated chronic disorder with still not fully elucidated complex mechanisms of pathogenesis and pathophysiology. Intestinal epithelial barrier (IEB) dysregulation is one of the major underlying mechanisms of inflammatory process induction in IBD. Proper IEB integrity is maintained to a large extent by intercellular tight junctions, the function of which can be modified by many molecules, including miRNAs. MiRNAs belong to noncoding and non-messenger RNAs, which can modulate gene expression by binding predicted mRNAs.
In this review, we summarize and discuss the potential role of miRNAs in the regulation of inflammatory signaling pathways affecting the function of the intestinal epithelial barrier in IBD, with particular emphasis on therapeutic potentials. The aim of the review is also to determine the further development directions of the studies on miRNA in the modulation of the intestinal epithelial barrier in IBD.

The functional role of miRNAs in inflammatory pathways associated with intestinal epithelial tight junction barrier regulation in IBD

Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze

Department of Oncological Surgery, Faculty of Medical Sciences in Zabrze

Postępy Higieny i Medycyny Doświadczalnej

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Inflammatory bowel disease – Crohn's disease and ulcerative colitis – is an immune-mediated chronic disorder with still not fully elucidated complex mechanisms...

The functional role of miRNAs in inflammatory pathways associated with intestinal epithelial tight junction barrier regulation in IBD

Article Category: Review

Pubblicato online: 29 giu 2022

Pagine: 254 - 267

Ricevuto: 18 ago 2021

Accettato: 28 dic 2021

DOI: https://doi.org/10.2478/ahem-2022-0038

Parole chiave
inflammatory bowel disease, microRNA, tight junction protein, intestinal barrier, intestinal inflammation, tissue therapy

© 2022 Błażej Ochman et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The functional role of miRNAs in inflammatory pathways associated with intestinal epithelial tight junction barrier regulation in IBD

Article Category: Review

Pubblicato online: 29 giu 2022

Pagine: 254 - 267

Ricevuto: 18 ago 2021

Accettato: 28 dic 2021

DOI: https://doi.org/10.2478/ahem-2022-0038

Parole chiaveinflammatory bowel disease, microRNA, tight junction protein, intestinal barrier, intestinal inflammation, tissue therapy

© 2022 Błażej Ochman et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Parole chiave
inflammatory bowel disease, microRNA, tight junction protein, intestinal barrier, intestinal inflammation, tissue therapy