The functional role of miRNAs in inflammatory pathways associated with intestinal epithelial tight junction barrier regulation in IBD
Błażej Ochman
Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of SilesiaZabrze, Poland
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, Agnieszka Kula
Department of Oncological Surgery, Faculty of Medical Sciences in Zabrze, Medical University of SilesiaKatowice, Poland
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et Elżbieta Świętochowska
Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of SilesiaZabrze, Poland
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29 juin 2022
À propos de cet article
Catégorie d'article: Review
Publié en ligne: 29 juin 2022
Pages: 254 - 267
Reçu: 18 août 2021
Accepté: 28 déc. 2021
DOI: https://doi.org/10.2478/ahem-2022-0038
Mots clés
© 2022 Błażej Ochman et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Fig. 1
MiRNAs collected in this review with their targets, marked expression in IBD, and altered TJ proteins expression_ The table was divided into in vivo and in vitro examined effects on TJ proteins expression induced by altered miRNA expression; miRNA–microRNA; ZO-1–Zonula occludens-1; CLDN–Claudin; JAM-A–junctional adhesion molecules A; AJ–adherent junction; CD–-Crohn's disease; UC–-ulcerative colitis; IBD–inflammatory bowel disease; PBMCs–peripheral blood mononuclear cells
| In vivo observed effects | ||||
| miRNA-124a | Aryl hydrocarbon receptor (AhR) | Overexpression in CD tissue | ZO-1 ↓, OCLN ↓, JAM-A ↓, CLDN1 ↓ | Zhao et al., 2020 [ |
| miRNA-31-5p | Activin receptor-like type 1 (ALK1) | Overexpression in CD tissue | CLDN8 ↓, TJP1 ↓, OCLN ↓ | Toyonaga et al., 2020 [ |
| miRNA-301A | B-cell translocation gene 1 (BTG1) | Overexpression in PBMCs and tissue in IBD | E-cadherin (AJ) ↓ | He et al., 2017 [ |
| miRNA-200b | Myosin light chain kinase (MLCK) and c-JUN | Decreased in IBD tissue | ZO-1 ↓, OCLN ↓ | Shen et al., 2017 [ |
| miRNA-21 | Claudin 8 (CLDN8) | Overexpression in CD tissue | CLDN8 ↓ | Li et al., 2018 [ |
| miRNA-200c-3p | Occludin (OCLN) | Overexpression in UC tissue | OCLN ↓ | Rawat et al., 2020 [ |
| miRNA-495 | Signal transducer and activator of transcription 3 (STAT3) | Decreased in UC tissue | CLDN1 ↓ | Chu et al., 2018 [ |
| miRNA-122a | Epidermal growth factor receptor (EGFR) | Overexpression in IBD tissue | CLDN1 ↓, OCLN ↓, Zonulin ↑ | Zhang et al., 2017 [ |
| miRNA-320a | Protein phosphatase 2 (PP2A) and Cell division cycle 42 (Cdc42) | Overexpression in serum of active CD | JAM-A ↑ | Cordes et al., 2016 [ |
| miRNA-423-5p | CLDN5 | Overexpression in UC tissue | CLDN5 ↓ | Wang et al., 2020 [ |
| In vitro observed effects | ||||
| miRNA-185-3p | Myosin light chain kinase (MLCK) | Decreased in IBD tissue | ZO-1 ↓, OCLN ↓ | Ma et al., 2019 [ |
| miRNA-23a | Tumor necrosis factor alpha inhibitor protein 3 (TNFAIP3) | Overexpression in CD tissue | OCLN destabilization | Felwick et al., 2020 [ |
| miRNA-675-5p | Vitamin D receptor (VDR) | Overexpression in UC tissue | ZO-1 ↓, OCLN ↓ | Chen et al., 2016 [ |
| miRNA-375 | Toll-like receptor 4 (TLR4) | Decreased in IBD tissue | ZO-1 ↓, OCLN ↓ | Wu et al., 2019 [ |
| miRNA-223 | Claudin 8 (CLDN8) | Overexpression in IBD tissue | CLDN8 ↓ | Wang et al., 2016 [ |