This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Rad S.Z., Rameshrad M., Hosseinzadeh H.: Toxicology effects of Berberis vulgaris (barberry) and its active constituent, berberine: A review. Iran J. Basic. Med. Sci., 2017; 20: 516-529RadS.Z.RameshradM.HosseinzadehH.Toxicology effects of Berberis vulgaris (barberry) and its active constituent, berberine: A reviewIran J. Basic. Med. Sci201720516529Search in Google Scholar
Wojciechowska I.: Berberys pospolity – roślina ozdobna i lecznicza. Kosmos. Problemy Nauk Biol., 2017; 66: 487-490WojciechowskaI.Berberys pospolity – roślina ozdobna i leczniczaKosmos. Problemy Nauk Biol201766487490Search in Google Scholar
Yu Y., Liu L., Wang X., Liu X., Liu X., Xie L., Wang G.: Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studies. Biochem. Pharmacol., 2010; 79: 1000-1006YuY.LiuL.WangX.LiuX.LiuX.XieL.WangG.Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studiesBiochem. Pharmacol2010791000100610.1016/j.bcp.2009.11.01719945441Search in Google Scholar
Zhang H., Wei J., Xue R., Wu J.D., Zhao W., Wang Z.Z., Wang S.K., Zhou Z.X., Song D.Q., Wang Y.M. i wsp.: Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism, 2010; 59: 285-292ZhangH.WeiJ.XueR.WuJ.D.ZhaoW.WangZ.Z.WangS.K.ZhouZ.X.SongD.Q.WangY.M. i wsp.Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expressionMetabolism20105928529210.1016/j.metabol.2009.07.02919800084Search in Google Scholar
Xing L.J., Zhang L., Liu T., Hua Y.Q., Zheng P.Y., Ji G.: Berberine reducing insulin resistance by up-regulating IRS-2 mRNA expression in non-alcoholic fatty liver disease (NAFLD) rat liver. Eur. J. Pharmacol., 2011; 668: 467-471XingL.J.ZhangL.LiuT.HuaY.Q.ZhengP.Y.JiG.Berberine reducing insulin resistance by up-regulating IRS-2 mRNA expression in non-alcoholic fatty liver disease (NAFLD) rat liverEur. J. Pharmacol201166846747110.1016/j.ejphar.2011.07.03621839075Search in Google Scholar
Xia X., Yan J., Shen Y., Tang K., Yin J., Zhang Y., Yang D., Liang H., Ye J., Weng J.: Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis. PLoS One, 2011; 6: e16556XiaX.YanJ.ShenY.TangK.YinJ.ZhangY.YangD.LiangH.YeJ.WengJ.Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesisPLoS One20116e1655610.1371/journal.pone.0016556303339021304897Search in Google Scholar
Abd El-Wahab A.E., Ghareeb D.A., Sarhan E.E., Abu-Serie M.M., El Demellawy M.A.: In vitro biological assessment of Berberis vulgaris and its active constituent, berberine: Antioxidants, antiacetylcholinesterase, anti-diabetic and anticancer effects. BMC Complement. Altern. Med., 2013; 13: 218AbdEl-Wahab A.E.GhareebD.A.SarhanE.E.Abu-SerieM.M.ElDemellawy M.A.In vitro biological assessment of Berberis vulgaris and its active constituent, berberine: Antioxidants, antiacetylcholinesterase, anti-diabetic and anticancer effectsBMC Complement. Altern. Med20131321810.1186/1472-6882-13-218401655024007270Search in Google Scholar
Boudjelthia K., Hammadi K., Kouidri M., Djebli N.: Evaluation of antidiabetic activity of two plants Berberis vulgaris and Zygophyllum geslini. J. Phys. Chem. Biophys., 2017; 7: 236BoudjelthiaK.HammadiK.KouidriM.DjebliN.Evaluation of antidiabetic activity of two plants Berberis vulgaris and Zygophyllum gesliniJ. Phys. Chem. Biophys2017723610.4172/2161-0398.1000236Search in Google Scholar
Chakrabarti R., Bhavtaran S., Narendra P., Varghese N., Vanchhawng L., Shihabudeen M.S., Thirumurgan K.: Dipeptidyl peptidase-IV inhibitory activity of Berberisaristata. J. Nat. Prod., 2011; 4: 158-163ChakrabartiR.BhavtaranS.NarendraP.VargheseN.VanchhawngL.ShihabudeenM.S.ThirumurganK.Dipeptidyl peptidase-IV inhibitory activity of BerberisaristataJ. Nat. Prod20114158163Search in Google Scholar
Jiang S.J., Dong H., Li J.B., Xu L.J., Zou X., Wang K.F., Lu F.E., Yi P.: Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats. World J. Gastroenterol., 2015; 21: 7777-7785JiangS.J.DongH.LiJ.B.XuL.J.ZouX.WangK.F.LuF.E.YiP.Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic ratsWorld J. Gastroenterol2015217777778510.3748/wjg.v21.i25.7777449196426167077Search in Google Scholar
Furrianca M.C., Alvear M., Zambrano T., Fajardo V., Salazar L.A.: Hypoglycemic effect of Berberis microphylla G Forst root extract. Trop. J. Pharm. Res., 2017; 16: 2179-2184FurriancaM.C.AlvearM.ZambranoT.FajardoV.SalazarL.A.Hypoglycemic effect of Berberis microphylla G Forst root extractTrop. J. Pharm. Res2017162179218410.4314/tjpr.v16i9.19Search in Google Scholar
Xu M., Xiao Y., Yin J., Hou W., Yu X., Shen L., Liu F., Wei L., Jia W.: Berberine promotes glucose consumption independently of AMP-activated protein kinase activation. PLoS One, 2014; 9: e103702XuM.XiaoY.YinJ.HouW.YuX.ShenL.LiuF.WeiL.JiaW.Berberine promotes glucose consumption independently of AMP-activated protein kinase activationPLoS One20149e10370210.1371/journal.pone.0103702411487425072399Search in Google Scholar
Zhang H., Wang X., Wang T., Chen K., Wang H., Jia Q., Li Y.: Enhancement of berberine hypoglycemic activity by oligomeric proanthocyanidins. Molecules, 2018; 23: 3318ZhangH.WangX.WangT.ChenK.WangH.JiaQ.LiY.Enhancement of berberine hypoglycemic activity by oligomeric proanthocyanidinsMolecules201823331810.3390/molecules23123318632125230558158Search in Google Scholar
Liu D., Zhang Y., Liu Y., Hou L., Li S., Tian H., Zhao T.: Berberine modulates gut microbiota and reduces insulin resistance via the TLR4 signaling pathway. Exp. Clin. Endocrinol. Diabetes, 2018; 126: 513-520LiuD.ZhangY.LiuY.HouL.LiS.TianH.ZhaoT.Berberine modulates gut microbiota and reduces insulin resistance via the TLR4 signaling pathwayExp. Clin. Endocrinol. Diabetes201812651352010.1055/s-0043-12506629365334Search in Google Scholar
Zhong Y., Jin J., Liu P., Song Y., Zhang H., Sheng L., Zhou H., Jiang B.: Berberine attenuates hyperglycemia by inhibiting the hepatic glucagon pathway in diabetic mice. Oxid. Med. Cell. Longev., 2020; 2020: 6210526ZhongY.JinJ.LiuP.SongY.ZhangH.ShengL.ZhouH.JiangB.Berberine attenuates hyperglycemia by inhibiting the hepatic glucagon pathway in diabetic miceOxid. Med. Cell. Longev20202020621052610.1155/2020/6210526696161131976031Search in Google Scholar
Liu L., Yu Y.L., Yang J.S, Li Y., Liu Y.W., Liang Y., Liu X.D., Xie L., Wang G.J.: Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study. Naunyn. Schmiedebergs. Arch. Pharmacol., 2010; 381: 371-381LiuL.YuY.L.YangJ.SLiY.LiuY.W.LiangY.LiuX.D.XieL.WangG.J.Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro studyNaunyn. Schmiedebergs. Arch. Pharmacol201038137138110.1007/s00210-010-0502-020229011Search in Google Scholar
Gong J., Hu M., Huang Z., Fang K., Wang D., Chen Q., Li J., Yang D., Zou X., Xu L. i wsp.: Berberine attenuates intestinal mucosal barrier dysfunction in type 2 diabetic rats. Front Pharmacol., 2017; 8: 42GongJ.HuM.HuangZ.FangK.WangD.ChenQ.LiJ.YangD.ZouX.XuL. i wsp.Berberine attenuates intestinal mucosal barrier dysfunction in type 2 diabetic ratsFront Pharmacol201784210.3389/fphar.2017.00042529045828217099Search in Google Scholar
Zhang Q., Xiao X., Feng K., Wang T., Li W., Yuan T., Sun X., Sun Q., Xiang H., Wang H.: Berberine moderates glucose and lipid metabolism through multipathway mechanism. Evid. Based Complement. Alternat. Med., 2011; 2011: 924851ZhangQ.XiaoX.FengK.WangT.LiW.YuanT.SunX.SunQ.XiangH.WangH.Berberine moderates glucose and lipid metabolism through multipathway mechanismEvid. Based Complement. Alternat. Med2011201192485110.1155/2011/924851295233420953398Search in Google Scholar
Gomes A.P., Duarte F.V., Nunes P., Hubbard B.P., Teodoro J.S., Varela A.T., Jones J.G., Sinclair D.A., Palmeira C.M., Rolo A.P.: Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. Biochem. Biophys. Acta, 2012; 1822: 185-195GomesA.P.DuarteF.V.NunesP.HubbardB.P.TeodoroJ.S.VarelaA.T.JonesJ.G.SinclairD.A.PalmeiraC.M.RoloA.P.Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesisBiochem. Biophys. Acta2012182218519510.1016/j.bbadis.2011.10.008336668822027215Search in Google Scholar
Mi J., He W., Lv J., Zhuang K., Huang H., Quan S.: Effect of berberine on the HPA-axis pathway and skeletal muscle GLUT4 in type 2 diabetes mellitus rats. Diabetes Metab. Syndr. Obes., 2019; 12: 1717-1725MiJ.HeW.LvJ.ZhuangK.HuangH.QuanS.Effect of berberine on the HPA-axis pathway and skeletal muscle GLUT4 in type 2 diabetes mellitus ratsDiabetes Metab. Syndr. Obes2019121717172510.2147/DMSO.S211188673198831564939Search in Google Scholar
Chen C., Zhang Y., Huang C.: Berberine inhibits PTP1B activity and mimics insulin action. Biochem. Biophys. Res. Commun., 2010; 397: 543-547ChenC.ZhangY.HuangC.Berberine inhibits PTP1B activity and mimics insulin actionBiochem. Biophys. Res. Commun201039754354710.1016/j.bbrc.2010.05.15320515652Search in Google Scholar
Yang J., Yin J., Gao H., Xu L., Wang Y., Xu L., Li M.: Berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokines profile in human preadipocytes and metabolic syndrome patients. Evid. Based Complement. Alternat. Med., 2012; 2012: 363845YangJ.YinJ.GaoH.XuL.WangY.XuL.LiM.Berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokines profile in human preadipocytes and metabolic syndrome patientsEvid. Based Complement. Alternat. Med2012201236384510.1155/2012/363845331016522474499Search in Google Scholar
Chang W., Zhang M., Li J., Meng Z., Wei S., Du H., Chen L., Hatch G.M.: Berberine improves insulin resistance in cardiomyocytes via activation of 5′-adenosine monophosphate-activated protein kinase. Metabolism, 2013; 62: 1159-1167ChangW.ZhangM.LiJ.MengZ.WeiS.DuH.ChenL.HatchG.M.Berberine improves insulin resistance in cardiomyocytes via activation of 5′-adenosine monophosphate-activated protein kinaseMetabolism2013621159116710.1016/j.metabol.2013.02.00723537779Search in Google Scholar
Zhang B., Pan Y., Xu L., Tang D., Dorfman R.G., Zhou Q., Yin Y., Li Y., Zhou L., Zhao S. i wsp.: Berberine promotes glucose uptake and inhibits gluconeogenesis by inhibiting deacetylase SIRT3. Endocrine, 2018; 62: 576-587ZhangB.PanY.XuL.TangD.DorfmanR.G.ZhouQ.YinY.LiY.ZhouL.ZhaoS. i wsp.Berberine promotes glucose uptake and inhibits gluconeogenesis by inhibiting deacetylase SIRT3Endocrine20186257658710.1007/s12020-018-1689-y30117113Search in Google Scholar
Chen Y., Wang Y., Zhang J., Sun C., Lopez A.: Berberine improves glucose homeostasis in streptozotocin-induced diabetic rats in association with multiple factors of insulin resistance. ISRN Endocrinol. 2011; 2011: 519371ChenY.WangY.ZhangJ.SunC.LopezA.Berberine improves glucose homeostasis in streptozotocin-induced diabetic rats in association with multiple factors of insulin resistanceISRN Endocrinol2011201151937110.5402/2011/519371326264622363882Search in Google Scholar
Xue M., Yang M.X., Zhang W., Li X.M., Gao D.H., Ou Z.M., Li Z.P., Liu S.H., Li X.J., Yang S.Y.: Characterization, pharmacokinetics, and hypoglycemic effect of berberine loaded solid lipid nanoparticles. Int. J. Nanomedicine, 2013; 8: 4677-4687XueM.YangM.X.ZhangW.LiX.M.GaoD.H.OuZ.M.LiZ.P.LiuS.H.LiX.J.YangS.Y.Characterization, pharmacokinetics, and hypoglycemic effect of berberine loaded solid lipid nanoparticlesInt. J. Nanomedicine201384677468710.2147/IJN.S51262386250924353417Search in Google Scholar
Almani S.A., Memon I.A., Shaikh T.Z., Khoharo H.K., Ujjan I.: Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus. Iran J. Basic Med. Sci., 2017; 20: 511-515AlmaniS.A.MemonI.A.ShaikhT.Z.KhoharoH.K.UjjanI.Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitusIran J. Basic Med. Sci201720511515Search in Google Scholar
Pérez-Rubio K.G., González-Ortiz M., Martínez-Abundis E., Robles-Cervantes J.A., Espiinel-Bermúdez M.C.: Effect of berberine administration on metabolic sydrome, insulin sensitivity, and insulin secretion. Metab. Syndr. Relat. Disord., 2013; 11: 366-369Pérez-RubioK.G.González-OrtizM.Martínez-AbundisE.Robles-CervantesJ.A.Espiinel-BermúdezM.C.Effect of berberine administration on metabolic sydrome, insulin sensitivity, and insulin secretionMetab. Syndr. Relat. Disord20131136636910.1089/met.2012.018323808999Search in Google Scholar
Chen L, Lu W, Li Y. Berberine ameliorates type 2 diabetes via modulation of Bifidobacterium species, tumor necrosis factor-α, and lipopolysaccharide. Int. J. Clin. Exp. Med., 2016; 9: 9365-9372ChenLLuWLiYBerberine ameliorates type 2 diabetes via modulation of Bifidobacterium species, tumor necrosis factor-α, and lipopolysaccharideInt. J. Clin. Exp. Med2016993659372Search in Google Scholar
Memon M.A., Khan R.N., Riaz S., Ain Q.U., Ahmed M., Kumar N.: Methylglyoxal and insulin resistance in berberine-treated type 2 diabetic patients. J. Res. Med. Sci., 2018; 23: 110MemonM.A.KhanR.N.RiazS.AinQ.U.AhmedM.KumarN.Methylglyoxal and insulin resistance in berberine-treated type 2 diabetic patientsJ. Res. Med. Sci201823110Search in Google Scholar
Sheng Z.X., Xie D.H.: Therapeutic effect of berberine on the levels of inflammatory factors in type 2 diabetic patients. New Med., 2010; 4: 177-180ShengZ.X.XieD.H.Therapeutic effect of berberine on the levels of inflammatory factors in type 2 diabetic patientsNew Med20104177180Search in Google Scholar
Cao C., Su M.: Effects of berberine on glucose-lipid metabolism, inflammatory factors and insulin resistance in patients with metabolic syndrome. Exp. Ther. Med., 2019; 17: 3009-3014CaoC.SuM.Effects of berberine on glucose-lipid metabolism, inflammatory factors and insulin resistance in patients with metabolic syndromeExp. Ther. Med2019173009301410.3892/etm.2019.7295643423530936971Search in Google Scholar
Shidfar F., Ebrahimi S.S., Hosseini S., Heydari I., Shidfar S., Hajhassani G.: The effects of Berberis vulgaris fruit extract on serum lipoproteins, apoB, apoA-I, homocysteine, glycemic control and total antioxidant capacity in type 2 diabetic patients. Iran J. Pharm. Res., 2012; 11: 643-652ShidfarF.EbrahimiS.S.HosseiniS.HeydariI.ShidfarS.HajhassaniG.The effects of Berberis vulgaris fruit extract on serum lipoproteins, apoB, apoA-I, homocysteine, glycemic control and total antioxidant capacity in type 2 diabetic patientsIran J. Pharm. Res201211643652Search in Google Scholar
Di Pierro F., Villanova N., Agostini F., Marzocchi R., Soverini V., Marchesini G.: Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control. Diabetes Metab. Syndr. Obes., 2012; 5: 213-217DiPierro F.VillanovaN.AgostiniF.MarzocchiR.SoveriniV.MarchesiniG.Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic controlDiabetes Metab. Syndr. Obes2012521321710.2147/DMSO.S33718Search in Google Scholar
Derosa G., Bonaventura A., Bianchi L., Romano D., D’Angelo A., Fogari E., Maffioli P.: Effects of Berberis aristata/Silybum marianum association on metabolic parameters and adipocytokines in overweight dyslipidemic patients. J. Biol. Regul. Homeost. Agents, 2013; 27: 717-728DerosaG.BonaventuraA.BianchiL.RomanoD.D’AngeloA.FogariE.MaffioliP.Effects of Berberis aristata/Silybum marianum association on metabolic parameters and adipocytokines in overweight dyslipidemic patientsJ. Biol. Regul. Homeost. Agents201327717728Search in Google Scholar
Di Pierro F., Bellone I., Rapacioli G., Putignano P.: Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statins. Diabetes Metab. Syndr. Obes, 2015; 8: 89-96DiPierro F.BelloneI.RapacioliG.PutignanoP.Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statinsDiabetes Metab. Syndr. Obes20158899610.2147/DMSO.S78877Search in Google Scholar
Guarino G., Strollo F., Carbone L., Della Corte T., Letizia M., Marino G., Gentile S.: Bioimpedance analysis, metabolic effects and safety of the association Berberis aristata/Silybum marianum: A 52-week double-blind, placebo-controlled study in obese patients with type 2 diabetes. J. Biol. Regul. Homeost. Agents, 2017; 31: 495-502GuarinoG.StrolloF.CarboneL.DellaCorte T.LetiziaM.MarinoG.GentileS.Bioimpedance analysis, metabolic effects and safety of the association Berberis aristata/Silybum marianum: A 52-week double-blind, placebo-controlled study in obese patients with type 2 diabetesJ. Biol. Regul. Homeost. Agents201731495502Search in Google Scholar
Li M.F., Zhou X.M., Li X.L.: The effect of berberine on polycystic ovary syndrome patients with insulin resistance (PCOS-IR): A meta-analysis and systematic review. Evid. Based Complement Alternat. Med., 2018; 2018: 2532935LiM.F.ZhouX.M.LiX.L.The effect of berberine on polycystic ovary syndrome patients with insulin resistance (PCOS-IR): A meta-analysis and systematic reviewEvid. Based Complement Alternat. Med20182018253293510.1155/2018/2532935626124430538756Search in Google Scholar