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Phospholipid bilayers in model membranes and drug delivery systems: from physics to pharmacy

D. Uhríková
D. Uhríková
   | 30 lug 2021
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Article Category: Special Issue Article
Pubblicato online: 30 lug 2021
Pagine: 66 - 71
Ricevuto: 16 giu 2021
Accettato: 17 giu 2021
DOI: https://doi.org/10.2478/afpuc-2021-0008
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© 2021 D. Uhríková, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Lyotropic liquid crystalline mesophases: (A) multilamellar vesicles; (B) inverted hexagonal phase; (C) cubic phase of Pn3m space group.
Lyotropic liquid crystalline mesophases: (A) multilamellar vesicles; (B) inverted hexagonal phase; (C) cubic phase of Pn3m space group.

Figure 2

(A) SANS curves of POPE/POPG vesicles; (B) CAM–POPE/POPG at P:L = 1:10 mol/mol (POPE/POPG = 3:1 mol/mol). Full lines represent fitting curves.
(A) SANS curves of POPE/POPG vesicles; (B) CAM–POPE/POPG at P:L = 1:10 mol/mol (POPE/POPG = 3:1 mol/mol). Full lines represent fitting curves.

Figure 3

Multilamellar CAM–POPE/POPG structure identified at liquid crystalline state of the lipids (36 °C). d – repeat distance.
Multilamellar CAM–POPE/POPG structure identified at liquid crystalline state of the lipids (36 °C). d – repeat distance.

Figure 4

SAXS pattern of a mixture of LFchimera and DMPC/DMPG at P:L = 1:21 mol/mol (t = 24 °C). Peaks of detected cubic phases Pn3m (black) and Im3m (blue) are assigned to spacing √(h2 + k2 + l2), where h, k and l are Miller indices. Models of cubic phases of Pn3m and Im3m space group.
SAXS pattern of a mixture of LFchimera and DMPC/DMPG at P:L = 1:21 mol/mol (t = 24 °C). Peaks of detected cubic phases Pn3m (black) and Im3m (blue) are assigned to spacing √(h2 + k2 + l2), where h, k and l are Miller indices. Models of cubic phases of Pn3m and Im3m space group.

Figure 5

SAXS patterns of DNA–CnNO/DOPE complexes (n = 8, 10, 16 and 18) prepared at CnNO/DOPE = 0.4 mol/mol in aqueous solutions at acidic and neutral/slightly alkaline conditions, respectively. Transfection efficiency of CnNO/DOPE (n = 8–18) complexes tested on U2OS cells.
SAXS patterns of DNA–CnNO/DOPE complexes (n = 8, 10, 16 and 18) prepared at CnNO/DOPE = 0.4 mol/mol in aqueous solutions at acidic and neutral/slightly alkaline conditions, respectively. Transfection efficiency of CnNO/DOPE (n = 8–18) complexes tested on U2OS cells.

Figure 6

(A) Schematic representation of pulmonary surfactant; (B) SAXS pattern of modified porcine surfactant, surfactant incubated with 10% of LPS for 2 hours and surfactant/LPS 10% with addition of 2% of PxB (at 37 °C).
(A) Schematic representation of pulmonary surfactant; (B) SAXS pattern of modified porcine surfactant, surfactant incubated with 10% of LPS for 2 hours and surfactant/LPS 10% with addition of 2% of PxB (at 37 °C).
eISSN:
2453-6725
Lingua:
Inglese
Frequenza di pubblicazione:
2 volte all'anno
Argomenti della rivista:
Pharmacy, other
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