- Journal Details
- First Published
- 08 Sep 2014
- Publication timeframe
- 2 times per year
- Open Access
Molecular Monitoring in Acute Myeloid Leukemia Patients Undergoing Matched Unrelated Donor – Hematopoietic Stem Cell Transplantation: Single Center Experience
Page range: 5 - 12
- minimal residual disease (MRD)
- molecular monitoring
- matched unrelated donor (MUD) hematopoietic stem cell transplantation (HSCT)
- acute myeloid leukemia (AML)
- Open Access
Diagnostic Central Obesity Indexes Cut – Off Point Values Determined with Dual-Energy X-Ray Absorptiometry in Cushing’s and Obese Women
Page range: 13 - 21
- abdominal obesity
- central obesity indexes
- cut-off point values
- Open Access
Prevalence of Rotaviruses in the Etiology of Acute Diarrhea in Young Children, Clinical forms, Extraintestinal Manifestations and Complications
Page range: 23 - 30
Rotavirus is highly contagious factor with dominant feces-oral transmission. Because it is stable in external environment, transmission clusters are possible by close contact, ingestion of contaminated water or food or contact with contaminated surfaces. It survives within hours and days on hands and contaminated surfaces. This makes it the most common enteric and nosocomial pathogen in the world, especially in early childhood. In addition to the rapid dehydration with pronounced electrolyte disturbances, numerous extraintestinal possibilities have been recorded in the clinical picture, which emphasizes the need for prevention of this disease.
In the period from 1.02.2018 to 31.01.2020 at the Clinic for Infectious diseases were treated 1060 patients with diarrheal disease, of which 502 children (47.36%). Rotavirus etiology was confirmed in 23.30% of the children. According to the protocols, laboratory and biochemical investigations were done to all 117 children, with tracking parameters and their dynamics of admission and discharge from the hospital. Most of the children, 84 (82.0 6%) are from urban areas, with a more confirmed epidemiological survey of 59 (42.00%). The average age of the children was 8 months, with a small percentage of children on maternal food (breastfed 25, i.e. 21.37%), with high febrile admission in 99% of children with an average temperature of 38.5oC and an average febrile duration of 4 days, with an average of 7 (+ 2.49) of stools and 5 (+ 2.12) of vomiting. There was a significant difference in hematocrit, leukocyte, electrolyte, glycaemia, and CRP values on admission and discharge. There was predominant isonatremic dehydration, and the compensatory mechanisms followed by the values of the electrolytes ABS, Ph, BE showed a tendency to maintain within the physiological limits. The clinical picture of extraintestinal manifestations included bronchitis, mesenteric lymphadenitis, upper respiratory infections and rash.
Rotavirus infection is a serious health and economic problem in our country, so it needs continuous prevention and monitoring in order to reduce the incidence, and thus the need for hospitalization and cure of rotavirus disease.
- clinical manifestations
- Open Access
Page range: 31 - 37
The aim of this study was to determine the prevalence of the most common phonological articulation disorders in preschool children, from 4-6 years old.
- speech disorders
- preschool children
- cross-sectional study
- global articulation test
- triple test
- Open Access
Comparison Between Dunking (Invagination) Pancreaticojejunoanastomosis and Double Layer Duct to Mucosa Anastomosis After Cephalic Duodenopancreatectomy-Whipple Procedure for Pancreatic Cephalic Carcinoma
Page range: 39 - 47
- pancreatic head carcinoma
- postoperative pancreatic fistula
- dunking anastomosis
- duct to mucosa anastomosis
- intra-hospital stay
- Open Access
Page range: 49 - 57
Plants that are primarily used as a food source commonly have undervalued biological properties beyond the basic supply of nutrients. One important example of this are the antimicrobial properties of plants. Inclusion of natural and food grade antimicrobial ingredients in recipes to prevent food spoilage and disease transmission, or in cosmetic products to prevent transient and pathogenic bacteria would have world-wide public health implications. A patented natural polyphenol rich sugar cane extract (PRSE), is marketed as a high anti-oxidant and polyphenol ingredient, but its anti-microbial activity has not been reported previously. We determined the anti-bacterial properties of PRSE on common human pathogens relating to a range of diseases including food poisoning, tooth decay, acne and severe skin infections using disc/well diffusion experiments. Our findings indicate that PRSE is an efficient antimicrobial, which could be included at differing dosages to target a range of food borne and environmental pathogens.
- sugar cane extract
- Staphylococcus aureus
- Staphylococcus epidermidis
- Streptococcus mutans
- Propionibacterium acnes
- Escherichia coli
- Open Access
Page range: 59 - 64
Predicting the outcome of neonatal critical patients remains elusive. The multiple factors of maternal state of health (infections, diabetes, gestosis), the placental situation (premature rupture of membranes) as well as multiple factors from the baby (small for gestational age, low Apgar score, low birth infections, mechanical ventilation, hypoglycaemia hyperglycamiea) render the approach to treatment of each patient individual and the outcome uncertain. Several approaches and scales are developed in order to assess the mortality risk in those rather complicated situations.
We used the CRIB-II scale to assess the mortality risk in 80 patients delivered in a large tertiary level hospital with more than 4,000 deliveries yearly. The patients were stratified according to all the neonatal risk factors and comorbidities. The CRIB-II scale identified well the mortality rates, but not the outcomes. A large and well-balanced cohort of patients followed for a longer period is required to discern in detail the importance of CRIB-II scale in predicting outcomes in high-risk new-borns. This could serve as an assistance to personalized approach to severely sick children. In addition, it is a valuable method in comparing outcomes in different NICUs and outcomes in different times in the same NICU, thus rendering possible improvements in the same unit and among several NICU departments.
- neonatal mortality
- high-risk babies
- CRIB-II score
- Open Access
Single-Stage Treatment of Aneurysm of the Distal Aortic Arch and Proximal Descending Aorta Using the Frozen Elephant Trunk Procedure. Case Report
Page range: 65 - 70
Aneurysms of the thoracic aorta involving the distal arch and the proximal descending aorta have traditionally been treated with two open procedures. During the first stage, the aortic arch pathology has been addressed through a median sternotomy. Several weeks or months later, a second stage followed and included completing the repair of the descending aorta through a lateral thoracotomy.
We, herein, report a single stage repair of an aneurysm involving the distal aortic arch and the proximal descending aorta using the frozen elephant trunk operative technique. Vascular hybrid stent graft prosthesis, specifically designed for treatment of extensive aortic aneurysms, has been used to replace the arch component and exclude the descending aorta component of the aneurysm through a median sternotomy, using bilateral antegrade cerebral perfusion and mild systemic hypothermia for intraoperative organ protection.
- frozen elephant trunk
- aortic arch
- Open Access
Page range: 71 - 75
Cat scratch disease (CSD) is the main clinical manifestation caused by Bartonella henselae in immuno-competent patients. The bacterium is transmitted to humans from cats via scratches or bites. In this case report, we are presenting to our knowledge the first etiologically confirmed case of CSD in our country. Here we describe the case of a previously healthy adult female patient presenting with fever and axillar lymphadenopathy over 1-month period. She underwent numerous clinical and paraclinical investigations for potential etiologies associated with lymphadenopathy and fever. Finally, serological testing for B.henselae was performed with titers for IgG 1:1024 and 1:160 for IgM, which confirmed the diagnosis. Five-day treatment with azithromycin resulted with good clinical response and complete recovery. We proved that CSD is a reality in our country and this report should raise awareness in medical doctors, especially infectious disease specialist. Also, CSD should be included in differential diagnosis in patients with fever of unkown origin (FUO), who are presenting with regional lymphadenopathy, with or without history of cat contact.
- cat scratch disease
- bartonella henselae
- fever of unknown origin
- Open Access
Page range: 77 - 90
Artificial Organs 2000 Satellite Symposium of European Society for Artificial Organs (ESAO) was organized by the Macedonian Society for Nephrology, Dialysis, Transplantation and Artificial Organs (MSNDTAO) and the Macedonian Academy of Sciences and Arts (MASA) on November 25-26, 2000 on the occasion of the 25th Anniversary of the Department of Nephrology of the Ss. Cyril and Methodius University, Skopje, R. Macedonia.
The main topics of this symposium were: Blood-purification techniques, Artificial Kidney, Metabolic- and Cardiac-Assist Systems as well as Biomaterials to be used for Artificial Organs.
H. Klinkmann (Glasgow, United Kingdom), D. Falkenhagen (Krems, Austria), U. Baurmeister (Wuppertal, Germany), V. Bonomini, S. Stefoni (Bologna, Italy), R. Vanholder (Ghent, Belgium), S. Stiller (Aachen, Germany), H. Mann, H. Melzer (Aachen, Germany), J. Pop-Jordanov, N. Pop-Jordanova (Skopje, R. Macedonia), B. Stegmayr (Umea, Sweden), M. Mydlik, K. Derzisova, O. Racz, A. Sipulova, J. Boldizsar, E. Lovasova, M. Hribikova (Kosice, Slovak Republic), A. Jörres (Berlin, Germany), M. Polenakovic (Skopje, R. Macedonia), J. Vienken (Bad Homburg, Germany), S. Bowry (Bad Homburg, Germany), E. Piskin (Ankara, Turkey), J. Klinkmann, W. Schimmelpfennig, H. Lantow, W. Rigger. (Teterow, Germany), A. Sikole (Skopje, R. Macedonia), A. Oncevski, P. Dejanov, V. Gerasimovska, M. Polenakovic (Skopje, R. Macedonia), J. Wojcicki (Warsaw, Poland), K. Affeld (Berlin, Germany), G. Rakhorst et al. (Groningen, The Netherlands), Z. Mitrev (Skopje, R. Macedonia), S. Kedev, G. Guagliumi, O. Valsecchi, M. Tespili (Skopje, R. Macedonia, Bergamo, Italy) have presented their papers at the Symposium. The presentations provoked a fruitful discussion and it was concluded that they should be published.
The papers were published in the International Journal of Artificial Organs of the European Society for Artificial Organs (ESAO) as a special issue on “Artificial Organs 2000 ESAO Satellite Symposium -Skopje, R. Macedonia”, Guest Editors: M. H. Polenakovic, Skopje and J. Vienken, Bad Homburg; Vol. 25, No. 5, 2002.
- Artificial Kidney
- Blood Purification
- Vascular Access
- Cardiac Assist Technology
- Metabolic Assist
- Tissue Engineering
- Open Access
A Scientific Symposium “Artificial Organs Today: From in Vitro Assessment to Human Therapies” on the Occasion of the Celebration of the 40th Anniversary of the Macedonian Academy of Sciences and Arts
Page range: 91 - 93
On the occasion of the celebration of the 40th anniversary of the Macedonian Academy of Sciences and Arts (MASA) the Macedonian Society of Nephrology, Dialysis, Transplantation and Artificial Organs (MSNDTAO) organized a one day symposium titled: “Artificial Organs Today: From in vitro assessment to human therapies”, on September 28, 2007 at the Macedonian Academy of Sciences and Arts. The following sessions were held: Artificial Organs in Front of the Ageing Populations; System Requirements for Artificial Organ Technology; Tools for Artificial Organ Technology; Extracorporeal Blood Circuits in Organ Replacement Therapies; Treatment Options for Blood Purification Therapies. Presentation were delivered by: Horst Klinkmann, Germany; Jörg Vienken, Germany; Jens Hartmann, Austria; Udo Losert, Austria; Jan Wojcicki, Poland; Helmut Mann and Siegfried Stiller, Germany; Beat Walpoth, Switzerland; Juan F. del Cañizo, Spain; Borce Georgievski, Macedonia; Bernd Stegmayr, Sweden; Momir Polenakovic, Macedonia; Petar Kes, Croatia; Aleksandar Sikole, Macedonia; Wolfgang Ramlow, Germany; Dieter Falkenhagen, Austria. These meetings are significant for the application and development of the artificial organs in patients.
- artificial organs
- heart support systems
- stem cells
- Open Access
Sixth Congresses of the Macedonian Society for Nephrology, Dialysis, Transplantation and Artificial Organs (MSNDTAO) – Stimulus for the Development of Nephrology in N. Macedonia
Page range: 95 - 121
The Macedonian Society for Nephrology, Dialysis, Transplantation and Artificial Organs (MSNDTAO) was established on September 1, 1992 in order to stimulate the development of nephrology and to unite experts from all professions interested in the research and treatment of kidney patients. Momir H. Polenakovic was elected President of MSNDTAO.
The First congress of MSNTAO was held in Ohrid from October, 7 to 10, 1993 in hotel “Desaret” under the auspices of the first President of R. Macedonia, Kiro Gligorov. During the Congress, the Balkan Cities Association of Nephrology, Dialysis, Transplantation and Artificial Organs (BANTAO) was formed on October 9, 1993. The idea of cooperation with the Department of Nephrology from the Ege University, Izmir, R. Turkey was promoted. Some of the presented papers were published in the Proceedings “Nephrology ’93” as a supplement to the Macedonian medical review. The “Doctrine for performing nephrological activity in the Republic of Macedonia” was also promoted.
The Second congress of MSNDTAO was held in Struga, R. Macedonia from September, 6 to 10, 1997 together with the Second BANTAO Congress. Selected papers were printed in the Macedonian Medical Review.
The Third congress of MSNDTAO was held from May, 30 to June 2, 2001 in Skopje, at the Macedonian Academy of Sciences and Arts (MASA). Proceedings of papers was also published.
In 2011 M. H. Polenakovic was elected Honorary President of MSNDTAO for life, and Goce Spasovski was elected the current President of MSNDTAO.
The Fourth congress of MSNDTAO was held in Ohrid from June, 21 to 24, 2012 together with the Fourth Meeting of the South-Eastern European Pediatric Nephrology Working Group (SEEPNWG).
The Fifth congress of MSNDTAO was held from June, 9 to 12, 2016 in Skopje, at MASA together with the 6th Southeastern European Pediatric Nephrology Working Group (SEPNWG) Meeting and IPNA (International Pediatric Nephrology Association) Teaching Course. The VIII Macedonian-Croatian Nephrology Days were also held during the Congress.
The Sixth congress of MSNDTAO was held from September, 26 to 29, 2019 along with the 15th BANTAO Congress, in Skopje, at MASA. The Congress also marked the 80th anniversary of the birth of M. H. Polenakovic.
Apart from the participants from R. Macedonia, the congress was attended by renowned nephrologists from Europe and the world.
A novelty of the last congresses was the organization of 9 CME (Continuing Medical Education) courses with famous lecturers. CME courses supported by the ERA-EDTA and / or the ISN were as follows: 2005 - Ohrid (BANTAO), 2006 - Skopje (MSNDTAO), 2009 - Skopje (MSNDTAO), 2010 - Skopje (ERA-EDTA - ESAO), 2011 Skopje (ERA-EDTA - EUTox group), 2012 - Ohrid (MSNDTAO), 2014 -Skopje (MSNDTAO), 2016 - Skopje (MSNDTAO), 2018 - Skopje (MSNDTAO - ERA-EDTA & ISN), 2019 - Skopje (BANTAO - ISN & ERA-EDTA).
In addition to the congresses, MSNDTAO has held meetings with nephrological associations from the neighboring countries as Croatia, Serbia, Albania and Kosovo.
The congresses of MSNDTAO contributed to the introduction and education of doctors in the diagnosis and treatment of kidney patients. They were a strong stimulus for the development of nephrology in R. Macedonia and beyond.
- Macedonian Society for Nephrology
- Transplantation and Artificial Organs (MSNDTAO)
- CME (Continuing Medical Education)