<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Cataract represents the reduction of the transparency of the crystalline lens. Cataract surgery is the most commonly performed surgical procedure worldwide. One of the most common postoperative complication of successfully performed cataract surgery is a development of posterior capsule opacification (PCO). In the postoperative period, lens epithelial cells (LECs) undergo proliferation, migration and differentiation, which is clinically manifested by the development of PCO. Inflammation has a central role in these processes. Cytokines, such as transforming growth factor β, fibroblast growth factor, interleukin 1, interleukin 6, matrix metalloproteinases have a huge effect on the activity of LECs. Understanding these processes can find a great usage in clinical practice. By prescribing anti-inflammatory therapy in the early postoperative period, the incidence of PCO can be significantly reduced.</p>
</abstract>

Cataract represents the reduction of the transparency of the crystalline lens. Cataract surgery is the most commonly performed surgical procedure worldwide. One of the most common postoperative complication of successfully performed cataract surgery is a development of posterior capsule opacification (PCO). In the postoperative period, lens epithelial cells (LECs) undergo proliferation, migration and differentiation, which is clinically manifested by the development of PCO. Inflammation has a central role in these processes. Cytokines, such as transforming growth factor β, fibroblast growth factor, interleukin 1, interleukin 6, matrix metalloproteinases have a huge effect on the activity of LECs. Understanding these processes can find a great usage in clinical practice. By prescribing anti-inflammatory therapy in the early postoperative period, the incidence of PCO can be significantly reduced.

The Influence of Inflammation in Posterior Capsule Opacification Development

Department of Ophthalmology, Faculty of medical sciences

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"The Influence of Inflammation in Posterior Capsule Opacification Development"}

Cataract represents the reduction of the transparency of the crystalline lens. Cataract surgery is the most commonly performed surgical procedure worldwide....

The Influence of Inflammation in Posterior Capsule Opacification Development

Publié en ligne: 12 févr. 2022

Pages: -

Reçu: 29 nov. 2021

Accepté: 12 janv. 2022

DOI: https://doi.org/10.2478/sjecr-2021-0075

Mots clés
Posterior capsule opacification, inflammation, anti-inflammatory therapy

© 2021 Dusan Todorovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The Influence of Inflammation in Posterior Capsule Opacification Development

Publié en ligne: 12 févr. 2022

Pages: -

Reçu: 29 nov. 2021

Accepté: 12 janv. 2022

DOI: https://doi.org/10.2478/sjecr-2021-0075

Mots clésPosterior capsule opacification, inflammation, anti-inflammatory therapy

© 2021 Dusan Todorovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
Posterior capsule opacification, inflammation, anti-inflammatory therapy