<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Cataract represents the reduction of the transparency of the crystalline lens. Cataract surgery is the most commonly performed surgical procedure worldwide. One of the most common postoperative complication of successfully performed cataract surgery is a development of posterior capsule opacification (PCO). In the postoperative period, lens epithelial cells (LECs) undergo proliferation, migration and differentiation, which is clinically manifested by the development of PCO. Inflammation has a central role in these processes. Cytokines, such as transforming growth factor β, fibroblast growth factor, interleukin 1, interleukin 6, matrix metalloproteinases have a huge effect on the activity of LECs. Understanding these processes can find a great usage in clinical practice. By prescribing anti-inflammatory therapy in the early postoperative period, the incidence of PCO can be significantly reduced.</p>
</abstract>

Cataract represents the reduction of the transparency of the crystalline lens. Cataract surgery is the most commonly performed surgical procedure worldwide. One of the most common postoperative complication of successfully performed cataract surgery is a development of posterior capsule opacification (PCO). In the postoperative period, lens epithelial cells (LECs) undergo proliferation, migration and differentiation, which is clinically manifested by the development of PCO. Inflammation has a central role in these processes. Cytokines, such as transforming growth factor β, fibroblast growth factor, interleukin 1, interleukin 6, matrix metalloproteinases have a huge effect on the activity of LECs. Understanding these processes can find a great usage in clinical practice. By prescribing anti-inflammatory therapy in the early postoperative period, the incidence of PCO can be significantly reduced.

The Influence of Inflammation in Posterior Capsule Opacification Development

Department of Ophthalmology, Faculty of medical sciences

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"The Influence of Inflammation in Posterior Capsule Opacification Development"}

Cataract represents the reduction of the transparency of the crystalline lens. Cataract surgery is the most commonly performed surgical procedure worldwide....

The Influence of Inflammation in Posterior Capsule Opacification Development

Published Online: Feb 12, 2022

Page range: -

Received: Nov 29, 2021

Accepted: Jan 12, 2022

DOI: https://doi.org/10.2478/sjecr-2021-0075

Keywords
Posterior capsule opacification, inflammation, anti-inflammatory therapy

© 2021 Dusan Todorovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The Influence of Inflammation in Posterior Capsule Opacification Development

Published Online: Feb 12, 2022

Page range: -

Received: Nov 29, 2021

Accepted: Jan 12, 2022

DOI: https://doi.org/10.2478/sjecr-2021-0075

KeywordsPosterior capsule opacification, inflammation, anti-inflammatory therapy

© 2021 Dusan Todorovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
Posterior capsule opacification, inflammation, anti-inflammatory therapy