<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec>
<h3>Introduction</h3>
<p>The relevance of this study lies in the fact, that today the search for biocompatible materials for the management of bone defects is of importance. Such materials could become an alternative to transplants. For the replacement of bone defects, two-phasic bioactive ceramics of hydroxyapatite and β-tricalcium phosphate is a very attractive biomaterial due to its excellent biocompatibility and osteoconductivity, but the results of its use are quite controversial due to insufficient bioactivity. The purpose of this work is to investigate the osseointegration properties of two-phase bioactive ceramics doped with silicon (HTdSi), both as a single component and a component in combination with platelet-rich fibrin, as well as in comparison with the well-known imported analogue – BIO, which consists of β-tricalcium phosphate, also as an independent component and a component in combination with platelet-rich fibrin. In the experiment, the rabbits of the New Zealand white breed at the age of 3 months and with an average weight of 2.5 kg were used. The terms of implantation are 30, 60, 90 and 180 days. The advantages of the domestic bio-composite are substantiated on the basis of clinical, radiological and histological studies.</p>
</sec>
<sec>
<h3>Material and methods</h3>
<p>In the experiment, the rabbits of the New Zealand white breed at the age of 3 months and with an average weight of 2.5 kg were used. The terms of implantation are 30, 60, 90 and 180 days.</p>
</sec>
<sec>
<h3>Results</h3>
<p>The osteointegration properties of two-phase bioactive ceramics doped with silicon (HTdSi), both as a single component and in combination with platelet fibrin, were investigated, as well as in comparison with the known imported analog - BIO, which contains β-tricalcium phosphate, both as a single component and in combination with platelet fibrin.</p>
</sec>
<sec>
<h3>Conclusions</h3>
<p>The advantages of domestic biocomposite are substantiated on the basis of clinical, radiological and histological studies.</p>
</sec>
</abstract>

Introduction
The relevance of this study lies in the fact, that today the search for biocompatible materials for the management of bone defects is of importance. Such materials could become an alternative to transplants. For the replacement of bone defects, two-phasic bioactive ceramics of hydroxyapatite and β-tricalcium phosphate is a very attractive biomaterial due to its excellent biocompatibility and osteoconductivity, but the results of its use are quite controversial due to insufficient bioactivity. The purpose of this work is to investigate the osseointegration properties of two-phase bioactive ceramics doped with silicon (HTdSi), both as a single component and a component in combination with platelet-rich fibrin, as well as in comparison with the well-known imported analogue – BIO, which consists of β-tricalcium phosphate, also as an independent component and a component in combination with platelet-rich fibrin. In the experiment, the rabbits of the New Zealand white breed at the age of 3 months and with an average weight of 2.5 kg were used. The terms of implantation are 30, 60, 90 and 180 days. The advantages of the domestic bio-composite are substantiated on the basis of clinical, radiological and histological studies.


Material and methods
In the experiment, the rabbits of the New Zealand white breed at the age of 3 months and with an average weight of 2.5 kg were used. The terms of implantation are 30, 60, 90 and 180 days.


Results
The osteointegration properties of two-phase bioactive ceramics doped with silicon (HTdSi), both as a single component and in combination with platelet fibrin, were investigated, as well as in comparison with the known imported analog - BIO, which contains β-tricalcium phosphate, both as a single component and in combination with platelet fibrin.


Conclusions
The advantages of domestic biocomposite are substantiated on the basis of clinical, radiological and histological studies.

Osseointegration properties of domestic bioactive calcium phosphate ceramics doped with silicon

Polish Journal of Medical Physics and Engineering

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Introduction
The relevance of this study lies in the fact, that today the search for biocompatible materials for the management of bone defects is of...

Osseointegration properties of domestic bioactive calcium phosphate ceramics doped with silicon

Article Category: Scientific Paper

Publié en ligne: 23 juin 2023

Pages: 113 - 129

Reçu: 13 mars 2023

Accepté: 30 mai 2023

DOI: https://doi.org/10.2478/pjmpe-2023-0013

Mots clés
bioactive calcium-phosphate ceramics, osseointegration, osteoinduction, clinical and radiological studies, histological studies

© 2023 Vitalii Pidgaietskyi et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Osseointegration properties of domestic bioactive calcium phosphate ceramics doped with silicon

Article Category: Scientific Paper

Publié en ligne: 23 juin 2023

Pages: 113 - 129

Reçu: 13 mars 2023

Accepté: 30 mai 2023

DOI: https://doi.org/10.2478/pjmpe-2023-0013

Mots clésbioactive calcium-phosphate ceramics, osseointegration, osteoinduction, clinical and radiological studies, histological studies

© 2023 Vitalii Pidgaietskyi et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
bioactive calcium-phosphate ceramics, osseointegration, osteoinduction, clinical and radiological studies, histological studies