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Erman H, Beydogan E, Cetin SI, Boyuk B. Endocan: A Biomarker for Hepatosteatosis in Patients with Metabolic Syndrome. Mediators Inflamm. 2020; 2020: 3534042.ErmanHBeydoganECetinSIBoyukBEndocan: A Biomarker for Hepatosteatosis in Patients with Metabolic Syndrome20202020353404210.1155/2020/3534042715297832317862Search in Google Scholar
Aizawa M, Inagaki S, Moriyama M, Asano K, Kakehashi M. Modeling the natural history of fatty liver using lifestyle-related risk factors: Effects of body mass index (BMI) on the life-course of fatty liver. PLoS One. 2019; 14(10):e0223683.AizawaMInagakiSMoriyamaMAsanoKKakehashiMModeling the natural history of fatty liver using lifestyle-related risk factors: Effects of body mass index (BMI) on the life-course of fatty liver20191410e022368310.1371/journal.pone.0223683680283731634357Search in Google Scholar
Zelber-Sagi S, Lotan R, Shlomai A, Webb M, Harrari G, Buch A, et al. Predictors for incidence and remission of NAFLD in the general population during a seven-year prospective follow-up. Journal of hepatology. 2012; 56(5): 1145-1151.Zelber-SagiSLotanRShlomaiAWebbMHarrariGBuchAet alPredictors for incidence and remission of NAFLD in the general population during a seven-year prospective follow-up20125651145115110.1016/j.jhep.2011.12.01122245895Search in Google Scholar
Sookoian S, Pirola CJ. Review article: shared disease mechanisms between non-alcoholic fatty liver disease and metabolic syndrome - translating knowledge from systems biology to the bedside. Aliment Pharmacol Ther. 2019; 49(5): 516-527.SookoianSPirolaCJReview article: shared disease mechanisms between non-alcoholic fatty liver disease and metabolic syndrome - translating knowledge from systems biology to the bedside201949551652710.1111/apt.1516330714632Search in Google Scholar
Friedman SL, Neuschwander-Tetri BA, Rinella M, Sanyal AJ. Mechanisms of NAFLD development and therapeutic strategies. Nat Med. 2018; 24(7):908-922.FriedmanSLNeuschwander-TetriBARinellaMSanyalAJMechanisms of NAFLD development and therapeutic strategies201824790892210.1038/s41591-018-0104-9655346829967350Search in Google Scholar
Rinella ME. Nonalcoholic fatty liver disease: a systematic review. JAMA. 2015; 313(22):2263-73.RinellaMENonalcoholic fatty liver disease: a systematic review20153132222637310.1001/jama.2015.537026057287Search in Google Scholar
Noureddin M, Rinella ME. Nonalcoholic Fatty liver disease, diabetes, obesity, and hepatocellular carcinoma. Clin Liver Dis. 2015; 19(2):361-79.NoureddinMRinellaMENonalcoholic Fatty liver disease, diabetes, obesity, and hepatocellular carcinoma20151923617910.1016/j.cld.2015.01.012665817125921668Search in Google Scholar
Fabbrini E, Magkos F, Mohammed BS, Pietka T, Abumrad NA, Patterson BW, et al. Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci USA. 2009;106(36):15430-5.FabbriniEMagkosFMohammedBSPietkaTAbumradNAPattersonBWet alIntrahepatic fat, not visceral fat, is linked with metabolic complications of obesity20091063615430510.1073/pnas.0904944106274126819706383Search in Google Scholar
Konerman MA, Jones JC, Harrison SA. Pharmacotherapy for NASH: Current and emerging. J Hepatol. 2018; 68(2):362-375.KonermanMAJonesJCHarrisonSAPharmacotherapy for NASH: Current and emerging201868236237510.1016/j.jhep.2017.10.01529122694Search in Google Scholar
Sookoian S, Rosselli MS, Gemma C, Burgueño AL, Fernández Gianotti T, Castaño GO, Pirola CJ. Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter. Hepatology. 2010; 52(6):1992-2000SookoianSRosselliMSGemmaCBurgueñoALFernández GianottiTCastañoGOPirolaCJEpigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter20105261992200010.1002/hep.2392720890895Search in Google Scholar
Liu NK, Xu XM. MicroRNA in central nervous system trauma and degenerative disorders. Physiol Genomics. 2011; 43(10):571-80LiuNKXuXMMicroRNA in central nervous system trauma and degenerative disorders201143105718010.1152/physiolgenomics.00168.2010311089121385946Search in Google Scholar
Piazzolla VA, Mangia A. Noninvasive Diagnosis of NAFLD and NASH. Cells. 2020; 9(4):1005PiazzollaVAMangiaANoninvasive Diagnosis of NAFLD and NASH202094100510.3390/cells9041005722647632316690Search in Google Scholar
Zou B, Yeo YH, Nguyen VH, Cheung R, Ingelsson E, Nguyen MH. Prevalence, characteristics and mortality outcomes of obese, nonobese and lean NAFLD in the United States, 1999-2016. J Intern Med. 2020; 288(1):139-151ZouBYeoYHNguyenVHCheungRIngelssonENguyenMHPrevalence, characteristics and mortality outcomes of obese, nonobese and lean NAFLD in the United States, 1999-20162020288113915110.1111/joim.1306932319718Search in Google Scholar
Lefebvre P, Lalloyer F, Baugé E, Pawlak M, Gheeraert C, Dehondt H, et al. Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin. JCI Insight. 2017 Jul 6;2(13):e92264LefebvrePLalloyerFBaugéEPawlakMGheeraertCDehondtHet alInterspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin2017Jul 6213e9226410.1172/jci.insight.92264549937028679947Search in Google Scholar
Barrett T, Troup DB, Wilhite SE, Ledoux P, Rudnev D, Evangelista C, et al. NCBI GEO: mining tens of millions of expression profiles--database and tools update. Nucleic Acids Res. 2007; 35(Database issue):D760-5BarrettTTroupDBWilhiteSELedouxPRudnevDEvangelistaCet alNCBI GEO: mining tens of millions of expression profiles--database and tools update200735Database issueD760510.1093/nar/gkl887166975217099226Search in Google Scholar
Braschi B, Denny P, Gray K, Jones T, Seal R, Tweedie S, et al. Genenames.org: the HGNC and VGNC resources in 2019. Nucleic Acids Res. 2019; 47(D1):D786-D792BraschiBDennyPGrayKJonesTSealRTweedieSet alGenenames.org: the HGNC and VGNC resources in 2019. Nucleic Acids Res47D1D786D79210.1093/nar/gky930632405730304474Search in Google Scholar
Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015; 43 (7):e47RitchieMEPhipsonBWuDHuYLawCWShiWSmythGKlimma powers differential expression analyses for RNA-sequencing and microarray studies2015437e4710.1093/nar/gkv007440251025605792Search in Google Scholar
Wang L, Cao C, Ma Q, Zeng Q, Wang H, Cheng Z, et al. RNA-seq analyses of multiple meristems of soybean: novel and alternative transcripts, evolutionary and functional implications. BMC Plant Biol. 2014; 14:169WangLCaoCMaQZengQWangHChengZet alRNA-seq analyses of multiple meristems of soybean: novel and alternative transcripts, evolutionary and functional implications20141416910.1186/1471-2229-14-169407008824939556Search in Google Scholar
Bonow RO. Braunwald` s Heart Disease: A Textbook of Cardiovascular Medicine, Single Volume, 9th Edition.BonowROSearch in Google Scholar
Szekely, G., Rizzo, M. Hierarchical Clustering via Joint Between-Within Distances: Extending Ward’s Minimum Variance Method. Journal of Classification; 2005; 22, 151–183SzekelyG.RizzoMHierarchical Clustering via Joint Between-Within Distances: Extending Ward’s Minimum Variance Method200522151–18310.1007/s00357-005-0012-9Search in Google Scholar
Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009; 4(1):44-57Huang daWShermanBTLempickiRASystematic and integrative analysis of large gene lists using DAVID bioinformatics resources200941445710.1038/nprot.2008.21119131956Search in Google Scholar
Huang da W, Sherman BT, Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 2009; 37(1):1-13Huang daWShermanBTLempickiRABioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists200937111310.1093/nar/gkn923261562919033363Search in Google Scholar
Huang Z, Shi J, Gao Y, Cui C, Zhang S, Li J, et al. HMDD v3.0: a database for experimentally supported human microRNA-disease associations. Nucleic Acids Res. 2019; 47(D1):D1013-D1017HuangZShiJGaoYCuiCZhangSLiJet alHMDD v3.0: a database for experimentally supported human microRNA-disease associations201947D1D1013D101710.1093/nar/gky1010632399430364956Search in Google Scholar
Paraskevopoulou MD, Vlachos IS, Karagkouni D, Georgakilas G, Kanellos I, Vergoulis T, et al. DI-ANA-LncBase v2: indexing microRNA targets on non-coding transcripts. Nucleic Acids Res. 2016; 44(D1):D231-8ParaskevopoulouMDVlachosISKaragkouniDGeorgakilasGKanellosIVergoulisTet alDI-ANA-LncBase v2: indexing microRNA targets on non-coding transcripts201644D1D231810.1093/nar/gkv1270470289726612864Search in Google Scholar
Li JH, Liu S, Zhou H, Qu LH, Yang JH. StarBase v2.0: Decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 2014; 42(Database issue):D92-7LiJHLiuSZhouHQuLHYangJHStarBase v2.0: Decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data201442Database issueD92710.1093/nar/gkt1248396494124297251Search in Google Scholar
Thorn CF, Klein TE, Altman RB. PharmGKB: the pharmacogenetics and pharmacogenomics knowledge base. Methods Mol Biol. 2005; 311:179-91ThornCFKleinTEAltmanRBPharmGKB: the pharmacogenetics and pharmacogenomics knowledge base20053111799110.1385/1-59259-957-5:17916100408Search in Google Scholar
Chen HJ, Liu J. Actein ameliorates hepatic steatosis and fibrosis in high fat diet-induced NAFLD by regulation of insulin and leptin resistant. Biomed Pharmacother. 2018; 97: 1386-1396.ChenHJLiuJActein ameliorates hepatic steatosis and fibrosis in high fat diet-induced NAFLD by regulation of insulin and leptin resistant2018971386139610.1016/j.biopha.2017.09.09329156528Search in Google Scholar
Pan X, Zheng M, Zou T, Liu W, Gu X, Zhang X, et al. The LEPR K109R and Q223R Might Contribute to the Risk of NAFLD: A Meta-Analysis. Curr Mol Med. 2018; 18(2): 91-99.PanXZhengMZouTLiuWGuXZhangXet alThe LEPR K109R and Q223R Might Contribute to the Risk of NAFLD: A Meta-Analysis2018182919910.2174/156652401866618070511041229974828Search in Google Scholar
Zhang Y, Xiang D, Hu X, Ruan Q, Wang L, Bao Z. Identification and study of differentially expressed miRNAs in aged NAFLD rats based on high-throughput sequencing. Ann Hepatol. 2020; 19(3):302-312ZhangYXiangDHuXRuanQWangLBaoZIdentification and study of differentially expressed miRNAs in aged NAFLD rats based on high-throughput sequencing202019330231210.1016/j.aohep.2019.12.00331899128Search in Google Scholar
Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. 2008; 40(12): 1461-1465.RomeoSKozlitinaJXingCPertsemlidisACoxDPennacchioLAet al200840121461146510.1038/ng.257259705618820647Search in Google Scholar
Kozlitina J, Smagris E, Stender S, Nordestgaard BG, Cohen JCJNG. Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease. 2014; 46(4): 352-356.KozlitinaJSmagrisEStenderSNordestgaardBGCohenJCJNG201446435235610.1038/ng.2901396978624531328Search in Google Scholar
Mancina RM, Dongiovanni P, Petta S, Pingitore P, Meroni M, Rametta R, et al. The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent. 2016; 150(5): 1219-1230.e1216.MancinaRMDongiovanniPPettaSPingitorePMeroniMRamettaRet al2016150512191230e121610.1053/j.gastro.2016.01.032484407126850495Search in Google Scholar
Eslam M, Hashem AM, Leung R, Romero-Gomez M, Berg T, Dore GJ, et al. ; International Hepatitis C Genetics Consortium (IHCGC). Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease. Nat Commun. 2015; 6:6422.EslamMHashemAMLeungRRomero-GomezMBergTDoreGJet alInternational Hepatitis C Genetics Consortium (IHCGC). Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease20156642210.1038/ncomms7422436652825740255Search in Google Scholar
Petta S, Valenti L, Marra F, Grimaudo S, Tripodo C, Bugianesi E, et al. MERTK rs4374383 polymorphism affects the severity of fibrosis in non-alcoholic fatty liver disease. 2016; 64(3): 682-690.PettaSValentiLMarraFGrimaudoSTripodoCBugianesiEet al201664368269010.1016/j.jhep.2015.10.01626596542Search in Google Scholar
Aller R, De Luis DA, Izaola O, González Sagrado M, Conde R, Pacheco D, et al. Lys656Asn polymorphism of leptin receptor, leptin levels and insulin resistance in patients with non alcoholic fatty liver disease. Eur Rev Med Pharmacol Sci. 2012;16(3):335-41.AllerRDe LuisDAIzaolaOGonzálezSagrado MCondeRPachecoDet alLys656Asn polymorphism of leptin receptor, leptin levels and insulin resistance in patients with non alcoholic fatty liver disease201216333541Search in Google Scholar
An BQ, Lu LL, Yuan C, Xin YN, Xuan SY. Leptin Receptor Gene Polymorphisms and the Risk of Non-Alcoholic Fatty Liver Disease and Coronary Atherosclerosis in the Chinese Han Population. Hepat Mon. 2016; 16(4):e35055.AnBQLuLLYuanCXinYNXuanSYLeptin Receptor Gene Polymorphisms and the Risk of Non-Alcoholic Fatty Liver Disease and Coronary Atherosclerosis in the Chinese Han Population2016164e3505510.5812/hepatmon.35055488849927257426Search in Google Scholar
Neville LF, Mathiak G, Bagasra O. The immunobiology of interferon-gamma inducible protein 10 kD (IP-10): a novel, pleiotropic member of the C-X-C chemokine superfamily. Cytokine Growth Factor Rev. 1997; 8(3):207-19.NevilleLFMathiakGBagasraOThe immunobiology of interferon-gamma inducible protein 10 kD (IP-10): a novel, pleiotropic member of the C-X-C chemokine superfamily1997832071910.1016/S1359-6101(97)00015-49462486Search in Google Scholar
Luster AD, Unkeless JC, Ravetch JV. Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature. 1985; 315(6021):672-6.LusterADUnkelessJCRavetchJVGamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins19853156021672610.1038/315672a03925348Search in Google Scholar
Bertola A, Bonnafous S, Anty R, Patouraux S, Saint-Paul MC, Iannelli A, et al. Hepatic expression patterns of inflammatory and immune response genes associated with obesity and NASH in morbidly obese patients. PLoS One. 2010; 5(10):e13577.BertolaABonnafousSAntyRPatourauxSSaint-PaulMCIannelliAet alHepatic expression patterns of inflammatory and immune response genes associated with obesity and NASH in morbidly obese patients2010510e1357710.1371/journal.pone.0013577296265121042596Search in Google Scholar
Zhang X, Shen J, Man K, Chu ES, Yau TO, Sung JC, et al. CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis. Journal of hepatology. 2014; 61(6): 1365-1375.ZhangXShenJManKChuESYauTOSungJCet alCXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis20146161365137510.1016/j.jhep.2014.07.00625048951Search in Google Scholar
Dong XC, Copps KD, Guo S, Li Y, Kollipara R, Depinho RA, et al. Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation. 2008; 8(1): 0-76.DongXCCoppsKDGuoSLiYKolliparaRDepinhoRAet al20088107610.1016/j.cmet.2008.06.006292966718590693Search in Google Scholar
Munekata K, Sakamoto K. Forkhead transcription factor Foxo1 is essential for adipocyte differentiation. In Vitro Cell Dev Biol Anim. 2009; 45(10):642-51.MunekataKSakamotoKForkhead transcription factor Foxo1 is essential for adipocyte differentiation200945106425110.1007/s11626-009-9230-519585174Search in Google Scholar
Li Y, Ma Z, Jiang S, Hu W, Li T, Di S, et al. A global perspective on FOXO1 in lipid metabolism and lipid-related diseases. Prog Lipid Res. 2017; 66: 42-49.LiYMaZJiangSHuWLiTDiSet alA global perspective on FOXO1 in lipid metabolism and lipid-related diseases201766424910.1016/j.plipres.2017.04.00228392404Search in Google Scholar
Xin Z, Ma Z, Hu W, Jiang S, Yang Z, Li T, et al. FOXO1/3: Potential suppressors of fibrosis. Ageing Res Rev. 2018; 41: 42-52.XinZMaZHuWJiangSYangZLiTet alFOXO1/3: Potential suppressors of fibrosis201841425210.1016/j.arr.2017.11.00229138094Search in Google Scholar
Valenti L, Dongiovanni P, Rametta R, Fracanzani AL, Fargion SJD, Disease L. FOXO1 genotype influences the susceptibility to and severity of NAFLD by modulating FOXO1 expression. 2009; 41(3):A2–A3.ValentiLDongiovanniPRamettaRFracanzaniALFargionSJDDiseaseL2009413A2A310.1016/j.dld.2008.12.010Search in Google Scholar