Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans

1Landrigan PJ, Fuller R, Hu H, Caravanos J, Cropper ML, Hanrahan D, Sandilya K, Chiles TC, Kumar P, Suk WA. Pollution and global health - An agenda for prevention. Environ Health Perspect 2018;126:084501. doi: 10.1289/ EHP3141Landrigan PJ Fuller R Hu H Caravanos J Cropper ML Hanrahan D Sandilya K Chiles TC Kumar P Suk WA Pollution and global health - An agenda for prevention Environ Health Perspect 2018126084501 10.1289/EHP3141Open DOISearch in Google Scholar

2Schwartz DA, Weis B, Wilson SH. The need for exposure health sciences. Environ Health Perspect 2005;113:A650. doi: 10.1289/ehp.113-1281298Schwartz DA Weis B Wilson SH The need for exposure health sciences Environ Health Perspect 2005113A650 10.1289/ehp.113-1281298Open DOISearch in Google Scholar

3Sexton K, Hattis D. Assessing cumulative health risks from exposure to environmental mixtures - Three fundamental questions. Environ Health Perspect 2007;115:825-32. doi: 10.1289/ehp.9333Sexton K Hattis D Assessing cumulative health risks from exposure to environmental mixtures - Three fundamental questions Environ Health Perspect 2007115825 32 10.1289/ehp.9333Open DOISearch in Google Scholar

4Sekovanić A, Jurasović J, Piasek M, Pašalić D, Orct T, Grgec AS, Stasenko S, Čakanić KB, Jazbec A. Metallothionein 2A gene polymorphism and trace elements in mother-newborn pairs in the Croatian population. J Trace Elem Med Biol 2018;45:163-70. doi: 10.1016/j.jtemb.2017.10.011Sekovanić A Jurasović J Piasek M Pašalić D Orct T Grgec AS Stasenko S Čakanić KB Jazbec A Metallothionein 2A gene polymorphism and trace elements in mother-newborn pairs in the Croatian population J Trace Elem Med Biol 201845163 70 10.1016/j.jtemb.2017.10.011Open DOISearch in Google Scholar

5Vallee BL. Metallothionein: historical review and perspectives. In: Kagi JHR, Norberg M, editors. Metallothionein. Experientia supplementum 34 / FEBS Symposia Series 59. Basel: Birkhäuser; 1979. p. 19-38. doi: 10.1007/978-3-0348-6493-0_1Vallee BL Metallothionein: historical review and perspectives In Kagi JHR Norberg M editors Metallothionein. Experientia supplementum 34 / FEBS Symposia Series 59 Basel Birkhäuser 1979 p 19 38 10.1007/978-3-0348-6493-0_1Open DOISearch in Google Scholar

6Nordberg M. Metallothioneins: historical review and state of knowledge. Talanta 1998;46:243-54. doi: 10.1016/s0039-9140(97)00345-7Nordberg M Metallothioneins: historical review and state of knowledge Talanta 199846243 54 10.1016/s0039-9140(97)00345-7Open DOISearch in Google Scholar

7Capdevila M, Bofill R, Palacios Ò, Atrian S. State-of-the-art of metallothioneins at the beginning of the 21^st century. Coordin Chem Rev 2012;256:46-62. doi: 10.1016/j.ccr.2011.07.006Capdevila M Bofill R Palacios Ò Atrian S State-of-the-art of metallothioneins at the beginning of the 21^st century Coordin Chem Rev 201225646 62 10.1016/j.ccr.2011.07.006Open DOISearch in Google Scholar

8Waalkes MP, Pérez-Ollé R. Role of metallothionein in the metabolism, transport and toxicity of metals. In: Zalups RK, Koropatnick J, editors. Molecular biology and toxicology of metals London and New York: Taylor & Francis; 2000. p. 414-59.Waalkes MP Pérez-Ollé R Role of metallothionein in the metabolism, transport and toxicity of metals In Zalups RK Koropatnick J editors Molecular biology and toxicology of metals London and New York Taylor & Francis 2000 p 414 59Search in Google Scholar

9Vašák M, Meloni G. Chemistry and biology of mammalian metallothioneins. J Biol Inorg Chem 2011;16:1067-78. doi: 10.1007/s00775-011-0799-2Vašák M Meloni G Chemistry and biology of mammalian metallothioneins J Biol Inorg Chem 2011161067 78 10.1007/s00775-011-0799-221647776Open DOISearch in Google Scholar

10Cai L, Liu MG, Cherian GM. Metallothionein and intracellular sequestration of metals. In: Guengerich FP, editor. Vol. 4. Biotransformation. Comprehensive toxicology 2^nd ed. Kidlington (UK): Elsevier Ltd.; 2010. p. 501-17.Cai L Liu MG Cherian GM Metallothionein and intracellular sequestration of metals In Guengerich FP editor. Vol. 4 Biotransformation. Comprehensive toxicology 2^nd ed Kidlington (UK) Elsevier Ltd 2010 p 501 1710.1016/B978-0-08-046884-6.00424-3Search in Google Scholar

11Babula P, Masarik M, Adam V, Eckschlager T, Stiborova M, Trnkova L, Skutkova H, Provaznik I, Hubalek J, Kizek R. Mammalian metallothioneins: properties and functions. Metallomics 2012;4:739-50. doi: 10.1039/c2mt20081cBabula P Masarik M Adam V Eckschlager T Stiborova M Trnkova L Skutkova H Provaznik I Hubalek J Kizek R Mammalian metallothioneins: properties and functions Metallomics 20124739 50 10.1039/c2mt20081c22791193Open DOISearch in Google Scholar

12Krężel A, Maret W. The functions of metamorphic metallothioneins in zinc and copper metabolism. Int J Mol Sci 2017;18:1237. doi: 10.3390/ijms18061237Krężel A Maret W The functions of metamorphic metallothioneins in zinc and copper metabolism Int J Mol Sci 2017181237 10.3390/ijms18061237Open DOISearch in Google Scholar

13Coyle P, Philcox JC, Carey LC, Rofe AM. Metallothionein: the multipurpose protein. Cell Mol Life Sci 2002;59:627-47. doi: 10.1007/s00018-002-8454-2Coyle P Philcox JC Carey LC Rofe AM Metallothionein: the multipurpose protein Cell Mol Life Sci 200259627 47 10.1007/s00018-002-8454-2Open DOISearch in Google Scholar

14Kimura T, Kambe T. The functions of metallothionein and ZIP and ZnT transporters: an overview and perspective. Int J Mol Sci 2016;17:336. doi: 10.3390/ijms17030336Kimura T Kambe T The functions of metallothionein and ZIP and ZnT transporters: an overview and perspective Int J Mol Sci 201617336 10.3390/ijms17030336Open DOISearch in Google Scholar

15Dziegiel P, Pula B, Kobierzycki C, Stasiolek M, Podhorska-Okolow M. Metallothioneins: structure and functions. In: Dziegiel P, Pula B, Kobierzycki C, Stasiolek M, Podhorska-Okolow M, editors. Metallothioneins in normal and cancer cells. Advances in anatomy, embryology and cell biology. New York/London: Springer; 2016. p. 3-20.Dziegiel P Pula B Kobierzycki C Stasiolek M Podhorska-Okolow M Metallothioneins: structure and functions In Dziegiel P Pula B Kobierzycki C Stasiolek M Podhorska-Okolow M editors Metallothioneins in normal and cancer cells. Advances in anatomy, embryology and cell biology New York/London Springer 2016 p 3 2010.1007/978-3-319-27472-0_2Search in Google Scholar

16Meloni G, Zovo K, Kazantseva J, Palumaa P, Vasák M. Organization and assembly of metal-thiolate clusters in epithelium-specific metallothionein-4. J Biol Chem 2006;281:14588-95. doi: 10.1074/jbc.M601724200Meloni G Zovo K Kazantseva J Palumaa P Vasák M Organization and assembly of metal-thiolate clusters in epithelium-specific metallothionein-4 J Biol Chem 200628114588 95 10.1074/jbc.M601724200Open DOISearch in Google Scholar

17Kojima Y, Berger C, Vallee BL, Kägi JH. Amino-acid sequence of equine renal metallothionein-1B. Proc Natl Acad Sci USA 1976;73:3413-7. doi: 10.1073/pnas.73.10.3413Kojima Y Berger C Vallee BL Kägi JH Amino-acid sequence of equine renal metallothionein-1B Proc Natl Acad Sci USA 1976733413 7 10.1073/pnas.73.10.3413Open DOISearch in Google Scholar

18Templeton DM, Dean PA, Cherian MG. The reaction of metallothionein with mercuribenzoate. A dialysis and ¹¹³Cd-n.m.r. study. Biochem J 1986;234:685-9. doi: 10.1042/bj2340685Templeton DM Dean PA Cherian MG The reaction of metallothionein with mercuribenzoate A dialysis and ¹¹³Cd-n.m.r. study. Biochem J 1986234685 9 10.1042/bj2340685Open DOISearch in Google Scholar

19Waalkes MP, Harvey MJ, Klaassen CD. Relative in vitro affinity of hepatic metallothionein for metals. Toxicol Lett 1984;20:33-9. doi: 10.1016/0378-4274(84)90179-6Waalkes MP Harvey MJ Klaassen CD Relative in vitro affinity of hepatic metallothionein for metals Toxicol Lett 19842033 9 10.1016/0378-4274(84)90179-6Open DOISearch in Google Scholar

20Nielson KB, Winge DR. Independence of the domains of metallothionein in metal binding. J Biol Chem 1985;260:8698701. PMID: 4019449Nielson KB Winge DR Independence of the domains of metallothionein in metal binding J Biol Chem 19852608698701 PMID: 401944910.1016/S0021-9258(17)39405-XSearch in Google Scholar

21Hamer DH. Metallothionein. Annu Rev Biochem 1986;55:913-51. doi: 10.1146/annurev.bi.55.070186.004405Hamer DH Metallothionein Annu Rev Biochem 198655913 51 10.1146/annurev.bi.55.070186.0044053527054Open DOISearch in Google Scholar

22Kägi JHR, Valee BL. Metallothionein: a cadmium- and zinc-containing protein from equine renal cortex. J Biol Chem 1960;235:3460-5. PMID: 13750713Kägi JHR Valee BL Metallothionein: a cadmium- and zinc-containing protein from equine renal cortex J Biol Chem 19602353460 5 PMID: 1375071310.1016/S0021-9258(18)64490-4Search in Google Scholar

23Day FA, Funk AE, Brady FO. In vivo and ex vivo displacement of zinc from metallothionein by cadmium and by mercury. Chem Biol Interact 1984;50:159-74. doi: 10.1016/0009-2797(84)90093-0Day FA Funk AE Brady FO In vivo and ex vivo displacement of zinc from metallothionein by cadmium and by mercury Chem Biol Interact 198450159 74 10.1016/0009-2797(84)90093-0Open DOISearch in Google Scholar

24Sabolić I, Breljak D, Škarica M, Herak-Kramberger CM. Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs. BioMetals 2010;23:897-926. doi: 10.1007/s10534-010-9351-zSabolić I Breljak D Škarica M Herak-Kramberger CM Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs BioMetals 201023897 926 10.1007/s10534-010-9351-zOpen DOISearch in Google Scholar

25Kägi JHR, Schäffer A. Biochemistry of metallothionein. Biochemistry 1988;27:8509-15. doi: 10.1021/bi00423a001Kägi JHR Schäffer A Biochemistry of metallothionein Biochemistry 1988278509 15 10.1021/bi00423a001Open DOISearch in Google Scholar

26Klaassen CD, Choudhuri S, McKim JM Jr, Lehman-McKeeman LD, Kershaw WC. In vitro and in vivo studies on the degradation of metallothionein. Environ Health Perspect 1994;102(Suppl 3):141-6. doi: 10.1289/ehp.94102s3141Klaassen CD Choudhuri S McKim JM Jr Lehman-McKeeman LD Kershaw WC In vitro and in vivo studies on the degradation of metallothionein Environ Health Perspect 1994102Suppl 3141 6 10.1289/ehp.94102s3141Open DOISearch in Google Scholar

27McKim JM Jr, Choudhuri S, Klaassen CD. In vitro degradation of apo-, zinc-, and cadmium-metallothionein by cathepsins B, C, and D. Toxicol Appl Pharmacol 1992;116:117-24. doi: 10.1016/0041-008x(92)90152-iMcKim JM Jr Choudhuri S Klaassen CD In vitro degradation of apo-, zinc-, and cadmium-metallothionein by cathepsins B, C, and D Toxicol Appl Pharmacol 1992116117 24 10.1016/0041-008x(92)90152-iOpen DOISearch in Google Scholar

28Yang Y, Maret W, Vallee BL. Differential fluorescence labeling of cysteinyl clusters uncovers high tissue levels of thionein. Proc Natl Acad Sci USA 2001;98:5556-9. doi: 10.1073/pnas.101123298Yang Y Maret W Vallee BL Differential fluorescence labeling of cysteinyl clusters uncovers high tissue levels of thionein Proc Natl Acad Sci USA 2001985556 9 10.1073/pnas.1011232983325111331777Open DOISearch in Google Scholar

29Eckschlager T, Adam V, Hrabeta J, Figova K, Kizek R. Metallothioneins and cancer. Curr Protein Pept Sci 2009;10:360-75. doi: 10.2174/138920309788922243Eckschlager T Adam V Hrabeta J Figova K Kizek R Metallothioneins and cancer Curr Protein Pept Sci 200910360 75 10.2174/13892030978892224319689357Open DOISearch in Google Scholar

30Krizkova S, Kepinska M, Emri G, Rodrigo MAM, Tmejova K, Nerudova D, Kizek R, Adam V. Microarray analysis of metallothioneins in human diseases - A review. J Pharm Biomed Analysis 2016;117:464-73. doi: 10.1016/j. jpba.2015.09.031Krizkova S Kepinska M Emri G Rodrigo MAM Tmejova K Nerudova D Kizek R Adam V Microarray analysis of metallothioneins in human diseases - A review J Pharm Biomed Analysis 2016117464 73 10.1016/j.jpba.2015.09.03126454339Open DOISearch in Google Scholar

31Krizkova S, Fabrik I, Adam V, Hrabeta J, Eckschlager T, Kizek R. Metallothionein - a promising tool for cancer diagnostics. Bratisl Lek Listy 2009;110:93-7. PMID: 19408840Krizkova S Fabrik I Adam V Hrabeta J Eckschlager T Kizek R Metallothionein - a promising tool for cancer diagnostics Bratisl Lek Listy 200911093 7 PMID: 19408840Search in Google Scholar

32Si M, Lang J. The roles of metallothioneins in carcinogenesis. J Hematol Oncol 2018;11:107. doi: 10.1186/s13045-018-0645-xSi M Lang J The roles of metallothioneins in carcinogenesis J Hematol Oncol 201811107 10.1186/s13045-018-0645-x610811530139373Open DOISearch in Google Scholar

33Carpenè E, Andreani G, Isani G. Metallothionein functions and structural characteristics. J Trace Elem Med Biol 2007;21(Suppl 1):35-9. doi: 10.1016/j.jtemb.2007.09.011Carpenè E Andreani G Isani G Metallothionein functions and structural characteristics J Trace Elem Med Biol 200721Suppl 135 9 10.1016/j.jtemb.2007.09.011Open DOISearch in Google Scholar

34Davis JJ, Hill HAO, Kurz A, Jacob C, Maret W, Vallee BL. A scanning tunneling microscopy study of rabbit metallothionein. PhysChemComm 1998;1:12-22. doi: 10.1039/A806057FDavis JJ Hill HAO Kurz A Jacob C Maret W Vallee BL A scanning tunneling microscopy study of rabbit metallothionein PhysChemComm 1998112 22 10.1039/A806057FOpen DOISearch in Google Scholar

35Richards MP, Cousins RJ. Mammalian zinc homeostasis: requirement for RNA and metallothionein synthesis. Biochem Biophys Res Commun 1975;64:1215-23. doi: 10.1016/0006-291x(75)90822-0Richards MP Cousins RJ Mammalian zinc homeostasis: requirement for RNA and metallothionein synthesis Biochem Biophys Res Commun 1975641215 23 10.1016/0006-291x(75)90822-0Open DOISearch in Google Scholar

36Richards MP, Cousins RJ. Metallothionein and its relationship to the metabolism of dietary zinc in rats. J Nutr 1976;106:15919. doi: 10.1093/jn/106.11.1591Richards MP Cousins RJ Metallothionein and its relationship to the metabolism of dietary zinc in rats J Nutr 197610615919 10.1093/jn/106.11.1591978266Open DOISearch in Google Scholar

37Cousins RJ. Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. Physiol Rev 1985;65:238-309. doi: 10.1152/ physrev.1985.65.2.238Cousins RJ Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin Physiol Rev 198565238 309 10.1152/physrev.1985.65.2.2383885271Open DOISearch in Google Scholar

38Kiela PR, Ghishan FK. Physiology of intestinal absorption and secretion. Best Pract Res Clin Gastroenterol 2016;30:14559. doi: 10.1016/j.bpg.2016.02.007Kiela PR Ghishan FK Physiology of intestinal absorption and secretion Best Pract Res Clin Gastroenterol 20163014559 10.1016/j.bpg.2016.02.007495647127086882Open DOISearch in Google Scholar

39Lönnerdal B, Sandberg AS, Sandström B, Kunz C. Inhibitory effects of phytic acid and other inositol phosphates on zinc and calcium absorption in suckling rats. J Nutr 1989;119:211-4. doi: 10.1093/jn/119.2.211Lönnerdal B Sandberg AS Sandström B Kunz C Inhibitory effects of phytic acid and other inositol phosphates on zinc and calcium absorption in suckling rats J Nutr 1989119211 4 10.1093/jn/119.2.2112918393Open DOISearch in Google Scholar

40Brewer GJ. Zinc acetate for the treatment of Wilson’s disease. Expert Opin Pharmacother 2001;2:1473-7. doi: 10.1517/14656566.2.9.1473Brewer GJ Zinc acetate for the treatment of Wilson’s disease Expert Opin Pharmacother 200121473 7 10.1517/14656566.2.9.147311585025Open DOISearch in Google Scholar

41Ranucci G, Di Dato F, Spagnuolo MI, Vajro P, Iorio R. Zinc monotherapy is effective in Wilson’s disease patients with mild liver disease diagnosed in childhood: a retrospective study. Orphanet J Rare Dis 2014;9:41. doi: 10.1186/17501172-9-41Ranucci G Di Dato F Spagnuolo MI Vajro P Iorio R Zinc monotherapy is effective in Wilson’s disease patients with mild liver disease diagnosed in childhood: a retrospective study Orphanet J Rare Dis 2014941 10.1186/17501172-9-41Open DOISearch in Google Scholar

42Miles AT, Hawksworth GM, Beattie JH, Rodilla V. Induction, regulation degradation, and biological significance of mammalian metallothioneins. Crit Rev Biochem Mol Biol 2000;35:35-70. doi: 10.1080/10409230091169168Miles AT Hawksworth GM Beattie JH Rodilla V Induction, regulation degradation, and biological significance of mammalian metallothioneins Crit Rev Biochem Mol Biol 20003535 70 10.1080/1040923009116916810755665Open DOISearch in Google Scholar

43McAleer MF, Tuan RS. Metallothionein overexpression in human trophoblastic cells protects against cadmium-induced apoptosis. In Vitro Mol Toxicol 2001;14:25-42. doi: 10.1089/109793301316882522McAleer MF Tuan RS Metallothionein overexpression in human trophoblastic cells protects against cadmium-induced apoptosis In Vitro Mol Toxicol 20011425 42 10.1089/109793301316882522Open DOISearch in Google Scholar

44Skutkova H, Babula P, Stiborova M, Eckschlager T, Trnkova L, Provaznik I, Hubalek J, Kizek R, Adam V. Structure, polymorphisms and electrochemistry of mammalian metallothioneins - a review. Int J Electrochem Sci 2012;7:12415-31.Skutkova H Babula P Stiborova M Eckschlager T Trnkova L Provaznik I Hubalek J Kizek R Adam V Structure, polymorphisms and electrochemistry of mammalian metallothioneins - a review Int J Electrochem Sci 2012712415 31Search in Google Scholar

45Ruttkay-Nedecky B, Nejdl L, Gumulec J, Zitka O, Masarik M, Eckschlager T, Stiborova M, Adam V, Kizek R. The role of metallothionein in oxidative stress. Int J Mol Sci 2013;14:6044-66. doi: 10.3390/ijms14036044Ruttkay-Nedecky B Nejdl L Gumulec J Zitka O Masarik M Eckschlager T Stiborova M Adam V Kizek R The role of metallothionein in oxidative stress Int J Mol Sci 2013146044 66 10.3390/ijms14036044Open DOISearch in Google Scholar

46Nordberg M, Nordberg GF. Toxicological aspects of metallothionein. Cell Mol Biol 2000;46:451-63. PMID: 10774933Nordberg M Nordberg GF Toxicological aspects of metallothionein Cell Mol Biol 200046451 63 PMID: 10774933Search in Google Scholar

47Bakka A, Webb M. Metabolism of zinc and copper in the neonate: changes in the concentrations and contents of thionein-bound Zn and Cu with age in the livers of the newborn of various mammalian species. Biochem Pharmacol 1981;30:721-5. doi: 10.1016/0006-2952(81)90157-XBakka A Webb M Metabolism of zinc and copper in the neonate: changes in the concentrations and contents of thionein-bound Zn and Cu with age in the livers of the newborn of various mammalian species Biochem Pharmacol 198130721 5 10.1016/0006-2952(81)90157-XOpen DOISearch in Google Scholar

48Nartey NO, Banerjee D, Cherian MG. Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of fetal human liver and kidney and its changes during d eve lop me n t . P a tho log y 1 9 8 7 ; 1 9 : 2 3 3 - 8 . do i : 10.3109/00313028709066555Nartey NO Banerjee D Cherian MG Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of fetal human liver and kidney and its changes during d eve lop me n t P a tho log y 1 9 8 7 ; 1 9 : 2 3 3 - 8 10.3109/00313028709066555Open DOISearch in Google Scholar

49Chan HM, Cherian MG. Ontogenic changes in hepatic metallothionein isoforms in prenatal and newborn rats. Biochem Cell Biol 1993;71:133-40. doi: 10.1139/o93-022Chan HM Cherian MG Ontogenic changes in hepatic metallothionein isoforms in prenatal and newborn rats Biochem Cell Biol 199371133 40 10.1139/o93-022Open DOISearch in Google Scholar

50Goering PL, Klaassen CD. Tolerance to cadmium-induced hepatotoxicity following cadmium pretreatment. Toxicol Appl Pharmacol 1984;74:308-13. doi: 10.1016/0041-008X(84)90283-7Goering PL Klaassen CD Tolerance to cadmium-induced hepatotoxicity following cadmium pretreatment Toxicol Appl Pharmacol 198474308 13 10.1016/0041-008X(84)90283-7Open DOISearch in Google Scholar

51Chan HM, Cherian MG. Protective roles of metallothionein and glutathione in hepatotoxicity of cadmium. Toxicology 1992;72:281-90. doi: 10.1016/0300-483X(92)90179-IChan HM Cherian MG Protective roles of metallothionein and glutathione in hepatotoxicity of cadmium Toxicology 199272281 90 10.1016/0300-483X(92)90179-IOpen DOISearch in Google Scholar

52Klaassen CD, Liu J, Diwan BA. Metallothionein protection of cadmium toxicity. Toxicol Appl Pharmacol 2009;238:21520. doi: 10.1016/j.taap.2009.03.026Klaassen CD Liu J Diwan BA Metallothionein protection of cadmium toxicity Toxicol Appl Pharmacol 200923821520 10.1016/j.taap.2009.03.026Open DOISearch in Google Scholar

53Freisinger E, Vašák M. Cadmium in metallothioneins. In: Sigel A, Sigel H, Sigel RKO, editors. Cadmium: from toxicity to essentiality. Metal ions in life sciences. Vol. 11. Dordrect: Springer; 2013. p. 339-71. doi: 10.1007/978-94-007-51798_11Freisinger E Vašák M Cadmium in metallothioneins In Sigel A Sigel H Sigel RKO editors Cadmium: from toxicity to essentiality. Metal ions in life sciences. Vol. 11 Dordrect Springer 2013 p 339 71 10.1007/978-94-007-51798_11Open DOISearch in Google Scholar

54Thornalley PJ, Vašák M. Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals. Biochim Biophys Acta 1985;827:36-44. doi: 10.1016/0167-4838(85)90098-6Thornalley PJ Vašák M Possible role for metallothionein in protection against radiation-induced oxidative stress Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals. Biochim Biophys Acta 198582736 44 10.1016/0167-4838(85)90098-6Open DOISearch in Google Scholar

55Sato M, Bremner I. Oxygen free radicals and metallothionein. Free Radic Biol Med 1993;14:325-37. doi: 10.1016/0891-5849(93)90029-TSato M Bremner I Oxygen free radicals and metallothionein Free Radic Biol Med 199314325 37 10.1016/0891-5849(93)90029-TOpen DOISearch in Google Scholar

56Zangger K, Öz G, Haslinger E, Kunert O, Armitage IM. Nitric oxide selectively releases metals from the amino-terminal domain of metallothioneins: potential role at inflammatory sites. FASEB J 2001;15:1303-5. doi: 10.1096/fj.00-0641fjeZangger K Öz G Haslinger E Kunert O Armitage IM Nitric oxide selectively releases metals from the amino-terminal domain of metallothioneins: potential role at inflammatory sites FASEB J 2001151303 5 10.1096/fj.00-0641fjeOpen DOISearch in Google Scholar

57Zhu J, Meeusen J, Krezoski S, Petering DH. Reactivity of Zn-, Cd-, and apo-metallothionein with nitric oxide compounds: in vitro and cellular comparison. Chem Res Toxicol 2010;23:422-31. doi: 10.1021/tx900387kZhu J Meeusen J Krezoski S Petering DH Reactivity of Zn-, Cd-, and apo-metallothionein with nitric oxide compounds: in vitro and cellular comparison Chem Res Toxicol 201023422 31 10.1021/tx900387kOpen DOISearch in Google Scholar

58Ma H, Su L, Yue H, Yin X, Zhao J, Zhang S, Kung H, Xu Z, Miao J. HMBOX1 interacts with MT2A to regulate autophagy and apoptosis in vascular endothelial cells. Sci Rep 2015;5:15121. doi: 10.1038/srep15121Ma H Su L Yue H Yin X Zhao J Zhang S Kung H Xu Z Miao J HMBOX1 interacts with MT2A to regulate autophagy and apoptosis in vascular endothelial cells Sci Rep 2015515121 10.1038/srep15121Open DOISearch in Google Scholar

59Stankovic RK, Chung RS, Penkowa M. Metallothioneins I and II: neuroprotective significance during CNS pathology. Int J Biochem Cell Biol 2007;39:484-9. doi: 10.1016/j. biocel.2006.09.010Stankovic RK Chung RS Penkowa M Metallothioneins I and II: neuroprotective significance during CNS pathology Int J Biochem Cell Biol 200739484 9 10.1016/j.biocel.2006.09.010Open DOISearch in Google Scholar

60Rofe AM, Barry EF, Shelton TL, Philcox JC, Coyle P. Paracetamol hepatotoxicity in metallothionein-null mice. Toxicology 1998;125:131-40. doi: 10.1016/s0300-483x(97)00172-8Rofe AM Barry EF Shelton TL Philcox JC Coyle P Paracetamol hepatotoxicity in metallothionein-null mice Toxicology 1998125131 40 10.1016/s0300-483x(97)00172-8Open DOISearch in Google Scholar

61Liu J, Liu Y, Hartley D, Klaassen CD, Shehin-Johnson SE, Lucas A, Cohen SD. Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity. J Pharmacol Exp Ther 1999;289:547-52. doi: 10.1007/978-3-0348-8847-9_81Liu J Liu Y Hartley D Klaassen CD Shehin-Johnson SE Lucas A Cohen SD Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity J Pharmacol Exp Ther 1999289547 52 10.1007/978-3-0348-8847-9_81Open DOISearch in Google Scholar

62Reeve VE, Nishimura N, Bosnic M, Michalska AE, Choo KHA. Lack of metallothionein-I and -II exacerbates the immunosuppressive effect of ultraviolet B radiation and cisurocanic acid in mice. Immunology 2000;100:399-404. doi: 10.1046/j.1365-2567.2000.00026.xReeve VE Nishimura N Bosnic M Michalska AE Choo KHA Lack of metallothionein-I and -II exacerbates the immunosuppressive effect of ultraviolet B radiation and cisurocanic acid in mice Immunology 2000100399 404 10.1046/j.1365-2567.2000.00026.xOpen DOISearch in Google Scholar

63Hanada K. Photoprotective role of metallothionein in UV-injury - metallothionein-null mouse exhibits reduced tolerance against ultraviolet-B. J Dermatol Sci 2000;23(Suppl 1):S51-6. doi: 10.1016/S0923-1811(99)00078-XHanada K Photoprotective role of metallothionein in UV-injury - metallothionein-null mouse exhibits reduced tolerance against ultraviolet-B J Dermatol Sci 200023Suppl 1S51 6 10.1016/S0923-1811(99)00078-XOpen DOISearch in Google Scholar

64Andrews GK. Regulation of metallothionein gene expression by oxidative stress and metal ions. Biochem Pharmacol 2000;59:95-104. doi: 10.1016/S0006-2952(99)00301-9Andrews GK Regulation of metallothionein gene expression by oxidative stress and metal ions Biochem Pharmacol 20005995 104 10.1016/S0006-2952(99)00301-9Open DOISearch in Google Scholar

65Sato M, Kondoh M. Recent studies on metallothionein: protection against toxicity of heavy metals and oxygen free radicals. Tohoku J Exp Med 2002;196:9-22. doi: 10.1620/tjem.196.9Sato M Kondoh M Recent studies on metallothionein: protection against toxicity of heavy metals and oxygen free radicals Tohoku J Exp Med 20021969 22 10.1620/tjem.196.9Open DOISearch in Google Scholar

66Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB. Human metallothionein genes are clustered on chromosome 16. Proc Natl Acad Sci USA 1984;81:5494-8. doi: 10.1073/pnas.81.17.5494Karin M Eddy RL Henry WM Haley LL Byers MG Shows TB Human metallothionein genes are clustered on chromosome 16 Proc Natl Acad Sci USA 1984815494 8 10.1073/pnas.81.17.5494Open DOISearch in Google Scholar

67Raudenska M, Gumulec J, Podlaha O, Sztalmachova M, Babula P, Eckschlager T, Adam V, Kizek R, Masarik M. Metallothionein polymorphisms in pathological processes. Metallomics 2014;6:55-68. doi: 10.1039/c3mt00132fRaudenska M Gumulec J Podlaha O Sztalmachova M Babula P Eckschlager T Adam V Kizek R Masarik M Metallothionein polymorphisms in pathological processes Metallomics 2014655 68 10.1039/c3mt00132fOpen DOISearch in Google Scholar

68Suzuki K, Koizumi S. Individual metal responsive elements of the human metallothionein-IIA gene independently mediate responses to various heavy metal signals. Ind Health 2000;38:87-90. doi: 10.2486/indhealth.38.87Suzuki K Koizumi S Individual metal responsive elements of the human metallothionein-IIA gene independently mediate responses to various heavy metal signals Ind Health 20003887 90 10.2486/indhealth.38.87Open DOISearch in Google Scholar

69Andersen RD, Taplitz SJ, Wong S, Bristol G, Larkin B, Herschman HR. Metal-dependent binding of a factor in vivo to the metal-responsive elements of the metallothionein 1 gene promoter. Mol Cell Biol 1987;7:3574-81. doi: 10.1128/MCB.7.10.3574Andersen RD Taplitz SJ Wong S Bristol G Larkin B Herschman HR Metal-dependent binding of a factor in vivo to the metal-responsive elements of the metallothionein 1 gene promoter Mol Cell Biol 198773574 81 10.1128/MCB.7.10.3574Open DOISearch in Google Scholar

70Brugnera E, Georgiev O, Radtke F, Heuchel R, Baker E, Sutherland GR, Schaffner W. Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1. Nucleic Acids Res 1994;22:3167-73. doi: 10.1093/nar/22.15.3167Brugnera E Georgiev O Radtke F Heuchel R Baker E Sutherland GR Schaffner W Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1 Nucleic Acids Res 1994223167 73 10.1093/nar/22.15.3167Open DOISearch in Google Scholar

71Palmiter RD. Regulation of metallothionein genes by heavy metals appears to be mediated by a zinc-sensitive inhibitor that interacts with a constitutively active transcription factor, MTF-1. Proc Natl Acad Sci USA 1994;91:1219-23. doi: 10.1073/pnas.91.4.1219Palmiter RD Regulation of metallothionein genes by heavy metals appears to be mediated by a zinc-sensitive inhibitor that interacts with a constitutively active transcription factor, MTF-1 Proc Natl Acad Sci USA 1994911219 23 10.1073/pnas.91.4.1219Open DOISearch in Google Scholar

72Otsuka F, Iwamatsu A, Suzuki K, Ohsawa M, Hamer DH, Koizumi S. Purification and characterization of a protein that binds to metal responsive elements of the human metallothionein IIA gene. J Biol Chem 1994;269:23700-7. PMID: 8089141Otsuka F Iwamatsu A Suzuki K Ohsawa M Hamer DH Koizumi S Purification and characterization of a protein that binds to metal responsive elements of the human metallothionein IIA gene J Biol Chem 199426923700 7 PMID: 808914110.1016/S0021-9258(17)31572-7Search in Google Scholar

73Davidson T, Ke Q, Costa M. Selected molecular mechanisms of metal toxicity and carcinogenicity. In: Nordberg GF, Fowler BA, Nordberg M, editors. Handbook on the toxicology of metals. 4^th ed. New York: Academic Press; 2015. p. 173-96.Davidson T Ke Q Costa M Selected molecular mechanisms of metal toxicity and carcinogenicity In Nordberg GF Fowler BA Nordberg M editors Handbook on the toxicology of metals 4^th ed New York Academic Press 2015 p 173 9610.1016/B978-0-444-59453-2.00009-3Search in Google Scholar

74Davis SR, Cousins RJ. Metallothionein expression in animals: a physiological perspective on function. J Nutr 2000;130:1085-8. doi: 10.1093/jn/130.5.1085Davis SR Cousins RJ Metallothionein expression in animals: a physiological perspective on function J Nutr 20001301085 8 10.1093/jn/130.5.108510801901Open DOISearch in Google Scholar

75Kojima I, Tanaka T, Inagi R, Nishi H, Aburatani H, Kato H, Miyata T, Fujita T, Nangaku M. Metallothionein is upregulated by hypoxia and stabilizes hypoxia-inducible factor in the kidney. Kidney Int 2009;75:268-77. doi: 10.1038/ki.2008.488Kojima I Tanaka T Inagi R Nishi H Aburatani H Kato H Miyata T Fujita T Nangaku M Metallothionein is upregulated by hypoxia and stabilizes hypoxia-inducible factor in the kidney Kidney Int 200975268 77 10.1038/ki.2008.48819148152Open DOISearch in Google Scholar

76Eibl JK, Abdallah Z, Ross GM. Zinc-metallothionein: a potential mediator of antioxidant defence mechanisms in response to dopamine-induced stress. Can J Physiol Pharmacol 2010;88:305-12. doi: 10.1139/Y10-022Eibl JK Abdallah Z Ross GM Zinc-metallothionein: a potential mediator of antioxidant defence mechanisms in response to dopamine-induced stress Can J Physiol Pharmacol 201088305 12 10.1139/Y10-02220393595Open DOISearch in Google Scholar

77Park YH, Lee YM, Kim DS, Park J, Suk K, Kim JK, Han HS. Hypothermia enhances induction of protective protein metallothionein under ischemia. J Neuroinflammation 2013;10:21. doi: 10.1186/1742-2094-10-21Park YH Lee YM Kim DS Park J Suk K Kim JK Han HS Hypothermia enhances induction of protective protein metallothionein under ischemia J Neuroinflammation 20131021 10.1186/1742-2094-10-21360799923374901Open DOISearch in Google Scholar

78Collins FS, Brooks LD, Chakravarti A. A DNA polymorphism discovery resource for research on human genetic variation. Genome Res 1998;8:1229-31. doi: 10.1101/gr.8.12.1229Collins FS Brooks LD Chakravarti A A DNA polymorphism discovery resource for research on human genetic variation Genome Res 199881229 31 10.1101/gr.8.12.12299872978Open DOISearch in Google Scholar

79Sherry ST, Ward M-H, Kholodov M, Baker J, Phan L, Smigielski EM, Sirotkin K. dbSNP: the NCBI database of genetic variation. Nucleic Acids Res 2001;29:308-11. doi: 10.1093/nar/29.1.308Sherry ST Ward M-H Kholodov M Baker J Phan L Smigielski EM Sirotkin K dbSNP: the NCBI database of genetic variation Nucleic Acids Res 200129308 11 10.1093/nar/29.1.3082978311125122Open DOISearch in Google Scholar

80Starska K, Bryś M, Forma E, Olszewski J, Pietkiewicz P, Lewy-Trenda I, Stasikowska-Kanicka O, Danilewicz M, Krześlak A. Metallothionein 2A core promoter region genetic polymorphism and its impact on the risk, tumor behavior, and recurrences of sinonasal inverted papilloma (Schneiderian papilloma). Tumour Biol 2015;36:8559-71. doi: 10.1007/ s13277-015-3616-7Starska K Bryś M Forma E Olszewski J Pietkiewicz P Lewy-Trenda I Stasikowska-Kanicka O Danilewicz M Krześlak A Metallothionein 2A core promoter region genetic polymorphism and its impact on the risk, tumor behavior, and recurrences of sinonasal inverted papilloma (Schneiderian papilloma) Tumour Biol 2015368559 71 10.1007/s13277-015-3616-7467200926036762Open DOISearch in Google Scholar

81Starska K, Krześlak A, Forma E, Olszewski J, Lewy-Trenda I, Osuch-Wójcikiewicz E, Bryś M. Genetic polymorphism of metallothionein 2A and risk of laryngeal cancer in a Polish population. Med Oncol 2014;31:75. doi: 10.1007/s12032-014-0075-8Starska K Krześlak A Forma E Olszewski J Lewy-Trenda I Osuch-Wójcikiewicz E Bryś M Genetic polymorphism of metallothionein 2A and risk of laryngeal cancer in a Polish population Med Oncol 20143175 10.1007/s12032-014-0075-824952512Open DOISearch in Google Scholar

82Krześlak A, Forma E, Jóźwiak P, Szymczyk A, Smolarz B, Romanowicz-Makowska H, Różański W, Bryś M. Metallothionein 2A genetic polymorphisms and risk of ductal breast cancer. Clin Exp Med 2014;14:107-13. doi: 10.1007/s10238-012-0215-4Krześlak A Forma E Jóźwiak P Szymczyk A Smolarz B Romanowicz-Makowska H Różański W Bryś M Metallothionein 2A genetic polymorphisms and risk of ductal breast cancer Clin Exp Med 201414107 13 10.1007/s10238-012-0215-4390769223053628Open DOISearch in Google Scholar

83Kita K, Miura N, Yoshida M, Yamazaki K, Ohkubo T, Imai Y, Naganuma A. Potential effect on cellular response to cadmium of a single-nucleotide A → G polymorphism in the promoter of the human gene for metallothionein IIA. Hum Genet 2006;120:553-60. doi: 10.1007/s00439-006-0238-6Kita K Miura N Yoshida M Yamazaki K Ohkubo T Imai Y Naganuma A Potential effect on cellular response to cadmium of a single-nucleotide A → G polymorphism in the promoter of the human gene for metallothionein IIA Hum Genet 2006120553 60 10.1007/s00439-006-0238-616927099Open DOISearch in Google Scholar

84Starska K, Bryś M, Forma E, Olszewski J, Pietkiewicz P, Lewy-Trenda I, Danilewicz M, Krześlak A. The effect of metallothionein 2A core promoter region single-nucleotide polymorphism on accumulation of toxic metals in sinonasal inverted papilloma tissues. Toxicol Appl Pharmacol 2015;285:187-97. doi: 10.1016/j.taap.2015.04.008Starska K Bryś M Forma E Olszewski J Pietkiewicz P Lewy-Trenda I Danilewicz M Krześlak A The effect of metallothionein 2A core promoter region single-nucleotide polymorphism on accumulation of toxic metals in sinonasal inverted papilloma tissues Toxicol Appl Pharmacol 2015285187 97 10.1016/j.taap.2015.04.00825900616Open DOISearch in Google Scholar

85Starska K, Krześlak A, Forma E, Olszewski J, Morawiec-Sztandera A, Aleksandrowicz P, Lewy-Trenda I, Bryś M. The -5A/G singlenucleotide polymorphism in the core promoter region of MT2A and its effect on allele-specific gene expression and Cd, Zn and Cu levels in laryngeal cancer. Toxicol Appl Pharmacol 2014;280:256-63. doi: 10.1016/j. taap.2014.08.016Starska K Krześlak A Forma E Olszewski J Morawiec-Sztandera A Aleksandrowicz P Lewy-Trenda I Bryś M The -5A/G singlenucleotide polymorphism in the core promoter region of MT2A and its effect on allele-specific gene expression and Cd, Zn and Cu levels in laryngeal cancer Toxicol Appl Pharmacol 2014280256 63 10.1016/j.taap.2014.08.01625157674Open DOISearch in Google Scholar

86Krześlak A, Forma E, Chwatko G, Jóźwiak P, Szymczyk A, Wilkosz J, Różański W, Bryś M. Effect of metallothionein 2A gene polymorphism on allele-specific gene expression and metal content in prostate cancer. Toxicol Appl Pharmacol 2013;268:278-85. doi: 10.1016/j.taap.2013.02.013Krześlak A Forma E Chwatko G Jóźwiak P Szymczyk A Wilkosz J Różański W Bryś M Effect of metallothionein 2A gene polymorphism on allele-specific gene expression and metal content in prostate cancer Toxicol Appl Pharmacol 2013268278 85 10.1016/j.taap.2013.02.01323466427Open DOISearch in Google Scholar

87Forma E, Krzeslak A, Wilkosz J, Jozwiak P, Szymczyk A, Rozanski W, Brys M. Metallothionein 2A genetic polymorphisms and risk of prostate cancer in a Polish population. Cancer Genet 2012;205:432-35. doi: 10.1016/j. cancergen.2012.05.005Forma E Krzeslak A Wilkosz J Jozwiak P Szymczyk A Rozanski W Brys M Metallothionein 2A genetic polymorphisms and risk of prostate cancer in a Polish population Cancer Genet 2012205432 35 10.1016/j.cancergen.2012.05.00522824183Open DOISearch in Google Scholar

88Białkowska K, Marciniak W, Muszynska M, Baszuk P, Gupta S, Jaworska-Bieniek K, Sukiennicki G, Durda K, Gromowski T, Prajzendanc K, Cybulski C, Huzarski T, Gronwald J, Debniak T, Scott RJ, Lubinski J, Jakubowska A. Association of zinc level and polymorphism in MMP-7 gene with prostate cancer in Polish population. PLoS One 2018;13:e0201065. doi: 10.1371/journal.pone.0201065Białkowska K Marciniak W Muszynska M Baszuk P Gupta S Jaworska-Bieniek K Sukiennicki G Durda K Gromowski T Prajzendanc K Cybulski C Huzarski T Gronwald J Debniak T Scott RJ Lubinski J Jakubowska A Association of zinc level and polymorphism in MMP-7 gene with prostate cancer in Polish population PLoS One 201813e0201065 10.1371/journal.pone.0201065605605430036379Open DOISearch in Google Scholar

89Tekin D, Kayaaltı Z, Aliyev V, Söylemezoğlu T. The effects of metallothionein 2A polymorphism on placental cadmium accumulation: Is metallothionein a modifying factor in transfer of micronutrients to the fetus? J Appl Toxicol 2012;32:270-5. doi: 10.1002/jat.1661Tekin D Kayaaltı Z Aliyev V Söylemezoğlu T The effects of metallothionein 2A polymorphism on placental cadmium accumulation: Is metallothionein a modifying factor in transfer of micronutrients to the fetus? J Appl Toxicol 201232270 5 10.1002/jat.166121328412Open DOISearch in Google Scholar

90Tekin D, Kayaaltı Z, Söylemezoğlu T. The effects of metallothionein 2A polymorphism on lead metabolism: are pregnant women with a heterozygote genotype for metallothionein 2A polymorphism and their newborns at risk of having higher blood lead levels? Int Arch Occup Environ Health 2012;85:631-7. doi: 10.1007/s00420-011-0711-yTekin D Kayaaltı Z Söylemezoğlu T The effects of metallothionein 2A polymorphism on lead metabolism: are pregnant women with a heterozygote genotype for metallothionein 2A polymorphism and their newborns at risk of having higher blood lead levels? Int Arch Occup Environ Health 201285631 7 10.1007/s00420-011-0711-y22005883Open DOISearch in Google Scholar

91Kayaaltı Z, Sahiner L, Durakoğlugil ME, Söylemezoğlu T. Distributions of interleukin-6 (IL-6) promoter and metallothionein 2A MT2A core promoter region gene polymorphisms and their associations with aging in Turkish population. Arch Gerontol Geriatr 2011;53:354-8. doi: 10.1016/j.archger.2011.01.001Kayaaltı Z Sahiner L Durakoğlugil ME Söylemezoğlu T Distributions of interleukin-6 (IL-6) promoter and metallothionein 2A MT2A core promoter region gene polymorphisms and their associations with aging in Turkish population Arch Gerontol Geriatr 201153354 8 10.1016/j.archger.2011.01.00121277639Open DOISearch in Google Scholar

92Kayaalti Z, Aliyev V, Söylemezoğlu T. The potential effect of metallothionein 2A -5A/G single nucleotide polymorphism on blood cadmium, lead, zinc and copper levels. Toxicol Appl Pharmacol 2011;256:1-7. doi: 10.1016/j. taap.2011.06.023Kayaalti Z Aliyev V Söylemezoğlu T The potential effect of metallothionein 2A -5A/G single nucleotide polymorphism on blood cadmium, lead, zinc and copper levels Toxicol Appl Pharmacol 20112561 7 10.1016/j.taap.2011.06.02321767559Open DOISearch in Google Scholar

93Kayaalti Z, Söylemezoğlu T. The polymorphism of core promoter region on metallothionein 2A-metal binding protein in Turkish population. Mol Biol Rep 2010;37:185-90. doi: 10.1007/s11033-009-9586-3Kayaalti Z Söylemezoğlu T The polymorphism of core promoter region on metallothionein 2A-metal binding protein in Turkish population Mol Biol Rep 201037185 90 10.1007/s11033-009-9586-319572214Open DOISearch in Google Scholar

94Kayaalti Z, Mergen G, Söylemezoğlu T. Effect of metallothionein core promoter region polymorphism on cadmium, zinc and copper levels in autopsy kidney tissues from a Turkish population. Toxicol Appl Pharmacol 2010;245:252-5. doi: 10.1016/j.taap.2010.03.007Kayaalti Z Mergen G Söylemezoğlu T Effect of metallothionein core promoter region polymorphism on cadmium, zinc and copper levels in autopsy kidney tissues from a Turkish population Toxicol Appl Pharmacol 2010245252 5 10.1016/j.taap.2010.03.00720303360Open DOISearch in Google Scholar

95Hattori Y, Naito M, Satoh M, Nakatochi M, Naito H, Kato M, Takagi S, Matsunaga T, Seiki T, Sasakabe T, Suma S, Kawai S, Okada R, Hishida A, Hamajima N, Wakai K. Metallothionein MT2A A-5G polymorphism as a risk factor for chronic kidney disease and diabetes: cross-sectional and cohort studies. Toxicol Sci 2016;152:181-93. doi: 10.1093/toxsci/kfw080Hattori Y Naito M Satoh M Nakatochi M Naito H Kato M Takagi S Matsunaga T Seiki T Sasakabe T Suma S Kawai S Okada R Hishida A Hamajima N Wakai K Metallothionein MT2A A-5G polymorphism as a risk factor for chronic kidney disease and diabetes: cross-sectional and cohort studies Toxicol Sci 2016152181 93 10.1093/toxsci/kfw080492254427122239Open DOISearch in Google Scholar

96Hayashi Y, Hashizume T, Wakida K, Satoh M, Uchida Y, Watabe K, Matsuyama Z, Kimura A, Inuzuka T, Hozumi I. Association between metallothionein genes polymorphisms and sporadic amyotrophic lateral sclerosis in a Japanese population. Amyotroph Lateral Scler 2006;7:22-6. doi: 10.1080/14660820600618766Hayashi Y Hashizume T Wakida K Satoh M Uchida Y Watabe K Matsuyama Z Kimura A Inuzuka T Hozumi I Association between metallothionein genes polymorphisms and sporadic amyotrophic lateral sclerosis in a Japanese population Amyotroph Lateral Scler 2006722 6 10.1080/1466082060061876616546755Open DOISearch in Google Scholar

97García M, Álvarez L, Fernández Á, González-Iglesias H, Escribano J, Fernández-Vega B, Villota E, Fernández-Vega Cueto L, Fernández-Vega Á, Coca-Prados M. Metallothionein polymorphisms in a Northern Spanish population with neovascular and dry forms of age-related macular degeneration. Ophthalmic Genet 2017;38:451-8. doi: 10.1080/13816810.2017.1288825García M Álvarez L Fernández Á González-Iglesias H Escribano J Fernández-Vega B Villota E Fernández-Vega Cueto L Fernández-Vega Á Coca-Prados M Metallothionein polymorphisms in a Northern Spanish population with neovascular and dry forms of age-related macular degeneration Ophthalmic Genet 201738451 8 10.1080/13816810.2017.128882528635422Open DOISearch in Google Scholar

98McElroy JA, Bryda EC, McKay SD, Schnabel RD, Taylor JF. Genetic variation at a metallothionein 2A promoter single-nucleotide polymorphism in white and black females in Midwestern United States. J Toxicol Environ Health A 2010;73:1283-7. doi: 10.1080/15287394.2010.485067McElroy JA Bryda EC McKay SD Schnabel RD Taylor JF Genetic variation at a metallothionein 2A promoter single-nucleotide polymorphism in white and black females in Midwestern United States J Toxicol Environ Health A 2010731283 7 10.1080/15287394.2010.48506720711930Open DOISearch in Google Scholar

99Stajnko A, Slejkovec Z, Mazej D, France-Stiglic A, Briski AS, Prpic I, Spiric Z, Horvat M, Falnoga I. Arsenic metabolites; selenium; and AS3MT MTHFR AQP4 AQP9 SELENOP INMT and MT2A polymorphisms in Croatian-Slovenian population from PHIME-CROME study. Environ Res 2019;170:301-19. doi: 10.1016/j.envres.2018.11.045Stajnko A Slejkovec Z Mazej D France-Stiglic A Briski AS Prpic I Spiric Z Horvat M Falnoga I Arsenic metabolites; selenium; and AS3MT MTHFR AQP4 AQP9 SELENOP INMT and MT2A polymorphisms in Croatian-Slovenian population from PHIME-CROME study Environ Res 2019170301 19 10.1016/j.envres.2018.11.04530612060Open DOISearch in Google Scholar

100Liu D, Wang M, Tian T, Wang XJ, Kang HF, Jin TB, Zhang SQ, Guan HT, Yang PT, Liu K, Liu XH, Xu P, Zheng Y, Dai ZJ. Genetic polymorphisms (rs10636 and rs28366003) in metallothionein 2A increase breast cancer risk in Chinese Han population. Aging (Albany NY) 2017;9:547-55. doi: 10.18632/aging.101177Liu D Wang M Tian T Wang XJ Kang HF Jin TB Zhang SQ Guan HT Yang PT Liu K Liu XH Xu P Zheng Y Dai ZJ Genetic polymorphisms (rs10636 and rs28366003) in metallothionein 2A increase breast cancer risk in Chinese Han population Aging (Albany NY) 20179547 55 10.18632/aging.101177536168028228606Open DOISearch in Google Scholar

101Shokrzadeh M, Mohammadpour A, Ghassemi-Barghi N, Hoseini V, Abediankenari S, Tabari YS. Metallothionein-2A (rs1610216&rs28366003) gene polymorphisms and the risk of stomach adenocarcinoma. Arq Gastroenterol 2019;56:36771. doi: 10.1590/S0004-2803.201900000-69Shokrzadeh M Mohammadpour A Ghassemi-Barghi N Hoseini V Abediankenari S Tabari YS Metallothionein-2A (rs1610216&rs28366003) gene polymorphisms and the risk of stomach adenocarcinoma Arq Gastroenterol 20195636771 10.1590/S0004-2803.201900000-6931721970Open DOISearch in Google Scholar

102González-Martínez F, Sánchez-Rodas D, Cáceres DD, Martínez MF, Quiñones LA, Johnson-Restrepo B. Arsenic exposure, profiles of urinary arsenic species, and polymorphism effects of glutathione-s-transferase and metallothioneins. Chemosphere 2018;212:927-36. doi: 10.1016/j.chemosphere.2018.08.139González-Martínez F Sánchez-Rodas D Cáceres DD Martínez MF Quiñones LA Johnson-Restrepo B Arsenic exposure, profiles of urinary arsenic species, and polymorphism effects of glutathione-s-transferase and metallothioneins Chemosphere 2018212927 36 10.1016/j.chemosphere.2018.08.13930286549Open DOISearch in Google Scholar

103Raudenska M, Dvorakova V, Pacal L, Chalasova K, Kratochvilova M, Gumulec J, Ruttkay-Nedecky B, Zitka O, Kankova K, Adam V, Masarik M. Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease. J Biochem Mol Toxicol 2017;31:e21891. doi: 10.1002/jbt.21891Raudenska M Dvorakova V Pacal L Chalasova K Kratochvilova M Gumulec J Ruttkay-Nedecky B Zitka O Kankova K Adam V Masarik M Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease J Biochem Mol Toxicol 201731e21891 10.1002/jbt.2189128059470Open DOISearch in Google Scholar

104Adams SV, Barrick B, Christopher EP, Shafer MM, Makar KW, Song X, Lampe JW, Vilchis H, Ulery A, Newcomb PA. Genetic variation in metallothionein and metal-regulatory transcription factor 1 in relation to urinary cadmium, copper, and zinc. Toxicol Appl Pharmacol 2015;289:381-8. doi: 10.1016/j.taap.2015.10.024Adams SV Barrick B Christopher EP Shafer MM Makar KW Song X Lampe JW Vilchis H Ulery A Newcomb PA Genetic variation in metallothionein and metal-regulatory transcription factor 1 in relation to urinary cadmium, copper, and zinc Toxicol Appl Pharmacol 2015289381 8 10.1016/j.taap.2015.10.024468929326529669Open DOISearch in Google Scholar

105Yang CC, Chuang CS, Lin CI, Wang CL, Huang YC, Chuang HY. The association of the blood lead level and serum lipid concentrations may be modified by the genetic combination of the metallothionein 2A polymorphisms rs10636 GC and rs28366003 AA. J Clin Lipidol 2017;11:234-41. doi: 10.1016/j.jacl.2016.12.010Yang CC Chuang CS Lin CI Wang CL Huang YC Chuang HY The association of the blood lead level and serum lipid concentrations may be modified by the genetic combination of the metallothionein 2A polymorphisms rs10636 GC and rs28366003 AA J Clin Lipidol 201711234 41 10.1016/j.jacl.2016.12.010Open DOISearch in Google Scholar

106Wang Y, Goodrich JM, Gillespie B, Werner R, Basu N, Franzblau A. An investigation of modifying effects of metallothionein single-nucleotide polymorphisms on the association between mercury exposure and biomarker levels. Environ Health Perspect 2012;120:530-4. doi: 10.1289/ehp.1104079Wang Y Goodrich JM Gillespie B Werner R Basu N Franzblau A An investigation of modifying effects of metallothionein single-nucleotide polymorphisms on the association between mercury exposure and biomarker levels Environ Health Perspect 2012120530 4 10.1289/ehp.1104079Open DOISearch in Google Scholar

107Pavić M, Turčić P, Ljubojević M. Forgotten partners and function regulators of inducible metallothioneins. Arh Hig Rada Toksikol 2019;70:256-64. doi: 10.2478/aiht-2019-70-3317Pavić M Turčić P Ljubojević M Forgotten partners and function regulators of inducible metallothioneins Arh Hig Rada Toksikol 201970256 64 10.2478/aiht-2019-70-3317Open DOISearch in Google Scholar

108Baird SK, Kurz T, Brunk UT. Metallothionein protects against oxidative stress induced lysosomal destabilization. Biochem J 2006;394:275-83. doi: 10.1042/BJ20051143Baird SK Kurz T Brunk UT Metallothionein protects against oxidative stress induced lysosomal destabilization Biochem J 2006394275 83 10.1042/BJ20051143Open DOISearch in Google Scholar

109Bresgen N, Eckl PM. Oxidative stress and the homeodynamics of iron metabolism. Biomolecules 2015;5:808-47. doi: 10.3390/biom5020808Bresgen N Eckl PM Oxidative stress and the homeodynamics of iron metabolism Biomolecules 20155808 47 10.3390/biom5020808Open DOISearch in Google Scholar

110El-Agha O, Gokmen GI. Smoking habits and cadmium intake in Turkey. Biol Trace Element Res 2002;88:31-43. doi: 10.1385/BTER:88:1:31El-Agha O Gokmen GI Smoking habits and cadmium intake in Turkey Biol Trace Element Res 20028831 43 10.1385/BTER:88:1:31Open DOISearch in Google Scholar

111Esteban-Vasallo MD, Aragonés N, Pollan M, López-Abente G, Perez-Gomez B. Mercury, cadmium, and lead levels in human placenta: a systematic review. Environ Health Perspect 2012;120:1369-77. doi: 10.1289/ehp.1204952Esteban-Vasallo MD Aragonés N Pollan M López-Abente G Perez-Gomez B Mercury, cadmium, and lead levels in human placenta: a systematic review Environ Health Perspect 20121201369 77 10.1289/ehp.1204952349194222591711Open DOISearch in Google Scholar

112Giacconi R, Cipriano C, Muti E, Costarelli L, Maurizio C, Saba V, Gasparini N, Malavolta M, Mocchegiani E. Novel -209A/G MT2A polymorphism in old patients with type 2 diabetes and atherosclerosis: relationship with inflammation (IL-6) and zinc. Biogerontology 2005;6:407-13. doi: 10.1007/ s10522-005-4907-yGiacconi R Cipriano C Muti E Costarelli L Maurizio C Saba V Gasparini N Malavolta M Mocchegiani E Novel -209A/G MT2A polymorphism in old patients with type 2 diabetes and atherosclerosis: relationship with inflammation (IL-6) and zinc Biogerontology 20056407 13 10.1007/s10522-005-4907-y16518702Open DOISearch in Google Scholar

113Giacconi R, Muti E, Malavolta M, Cipriano C, Costarelli L, Bernardini G, Gasparini N, Mariani E, Saba V, Boccoli G, Mocchegiani E. The +838 C/G MT2A polymorphism, metals, and the inflammatory/immune response in carotid artery stenosis in elderly people. Mol Med 2007;13:388-95. doi: 10.2119/2007-00045Giacconi R Muti E Malavolta M Cipriano C Costarelli L Bernardini G Gasparini N Mariani E Saba V Boccoli G Mocchegiani E The +838 C/G MT2A polymorphism, metals, and the inflammatory/immune response in carotid artery stenosis in elderly people Mol Med 200713388 95 10.2119/2007-00045Open DOISearch in Google Scholar

114Kozarova R, Postadzhiyan A, Apostolova MD. Association of +1245 A/G MT 1A and -209 A/G MT2A polymorphysms with coronary artery disease and diabetes mellitus in Bulgarian cohort. Biotechnol Biotec Eq 2012;26(Suppl 1):100-6. doi: 10.5504/50YRTIMB.2011.0019Kozarova R Postadzhiyan A Apostolova MD Association of +1245 A/G MT 1A and -209 A/G MT2A polymorphysms with coronary artery disease and diabetes mellitus in Bulgarian cohort Biotechnol Biotec Eq 201226Suppl 1100 6 10.5504/50YRTIMB.2011.0019Open DOISearch in Google Scholar

115Yang L, Li H, Yu T, Zhao H, Cherian M G, Cai L, Liu Y. Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications. Am J Physiol Endocrinol Metab 2008;294:E987-92. doi: 10.1152/ajpendo.90234.2008Yang L Li H Yu T Zhao H Cherian M G Cai L Liu Y Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications Am J Physiol Endocrinol Metab 2008294E987 92 10.1152/ajpendo.90234.200818349110Open DOISearch in Google Scholar

116Woods JS, Heyer NJ, Russo JE, Martin MD, Pillai PB, Farin FM. Modification of neurobehavioral effects of mercury by genetic polymorphisms of metallothionein in children. Neurotoxicol Teratol 2013;39:36-44. doi: 10.1016/j. ntt.2013.06.004Woods JS Heyer NJ Russo JE Martin MD Pillai PB Farin FM Modification of neurobehavioral effects of mercury by genetic polymorphisms of metallothionein in children Neurotoxicol Teratol 20133936 44 10.1016/j.ntt.2013.06.004379592623827881Open DOISearch in Google Scholar

117Yang XY, Sun JH, Ke HY, Chen YJ, Xu M, Luo GH. Metallothionein 2A genetic polymorphism and its correlation to coronary heart disease. Eur Rev Med Pharmacol Sci 2014;18:3747-53. PMID: 25555862Yang XY Sun JH Ke HY Chen YJ Xu M Luo GH Metallothionein 2A genetic polymorphism and its correlation to coronary heart disease Eur Rev Med Pharmacol Sci 2014183747 53 PMID: 25555862Search in Google Scholar

118Chen X, Lei L, Tian L, Zhu G, Jin T. Bone mineral density and polymorphisms in metallothionein 1A and 2A in a Chinese population exposed to cadmium. Sci Total Environ 2012;423:12-7. doi: 10.1016/j.scitotenv.2012.02.020Chen X Lei L Tian L Zhu G Jin T Bone mineral density and polymorphisms in metallothionein 1A and 2A in a Chinese population exposed to cadmium Sci Total Environ 201242312 7 10.1016/j.scitotenv.2012.02.02022391096Open DOISearch in Google Scholar

119Fernandes KC, Martins AC Jr, Oliveira AÁ, Antunes LM, Cólus IM, Barbosa F Jr, Barcelos GR. Polymorphism of metallothionein 2A modifies lead body burden in workers chronically exposed to the metal. Public Health Genomics 2016;19:47-52. doi: 10.1159/000441713Fernandes KC Martins AC Jr Oliveira AÁ Antunes LM Cólus IM Barbosa F Jr Barcelos GR Polymorphism of metallothionein 2A modifies lead body burden in workers chronically exposed to the metal Public Health Genomics 20161947 52 10.1159/00044171326594907Open DOISearch in Google Scholar

120Gundacker C, Wittmann KJ, Kukuckova M, Komarnicki G, Hikkel I, Gencik M. Genetic background of lead and mercury metabolism in a group of medical students in Austria. Environ Res 2009;109:786-96. doi: 10.1016/j.envres.2009.05.003Gundacker C Wittmann KJ Kukuckova M Komarnicki G Hikkel I Gencik M Genetic background of lead and mercury metabolism in a group of medical students in Austria Environ Res 2009109786 96 10.1016/j.envres.2009.05.00319515364Open DOISearch in Google Scholar

121Ganguly S, Taioli E, Baranski B, Cohen B, Toniolo P, Garte SJ. Human metallothionein gene expression determined by quantitative reverse transcription-polymerase chain reaction as a biomarker of cadmium exposure. Cancer Epidemiol Biomarkers Prev 1996;5:297-301. PMID: 8722222Ganguly S Taioli E Baranski B Cohen B Toniolo P Garte SJ Human metallothionein gene expression determined by quantitative reverse transcription-polymerase chain reaction as a biomarker of cadmium exposure Cancer Epidemiol Biomarkers Prev 19965297 301 PMID: 8722222Search in Google Scholar

122Lu J, Jin T, Nordberg G, Nordberg M. Metallothionein gene expression in peripheral lymphocytes from cadmium-exposed workers. Cell Stress Chaperones 2001;6:97-104. doi: 10.1379/1466-1268(2001)006<0097Lu J Jin T Nordberg G Nordberg M Metallothionein gene expression in peripheral lymphocytes from cadmium-exposed workers Cell Stress Chaperones 2001697 104 10.1379/1466-12682001006<0097Open DOISearch in Google Scholar

123Chen L, Jin T, Huang B, Nordberg G, Nordberg M. Critical exposure level of cadmium for elevated urinary metallothionein - An occupational population study in China. Toxicol Appl Pharmacol 2006;215:93-9. doi: 10.1016/j. taap.2006.01.013Chen L Jin T Huang B Nordberg G Nordberg M Critical exposure level of cadmium for elevated urinary metallothionein - An occupational population study in China Toxicol Appl Pharmacol 200621593 9 10.1016/j.taap.2006.01.01316510161Open DOISearch in Google Scholar

124Huang ZY, Zhang Q, Chen J, Zhuang ZX, Wang XR. Bioaccumulation of metals and induction of metallothioneins in selected tissues of common carp Cyprinus carpio L. co-exposed to cadmium, mercury and lead. Appl Organomet Chem 2007;21:101-7. doi: 10.1002/aoc.1167Huang ZY Zhang Q Chen J Zhuang ZX Wang XR Bioaccumulation of metals and induction of metallothioneins in selected tissues of common carp Cyprinus carpio L. co-exposed to cadmium, mercury and lead Appl Organomet Chem 200721101 7 10.1002/aoc.1167Open DOISearch in Google Scholar

125Figueira E, Branco D, Antunes SC, Gonçalves F, Freitas R. Are metallothioneins equally good biomarkers of metal and oxidative stress? Ecotoxicol Environ Saf 2012;84:185-90. doi: 10.1016/j.ecoenv.2012.07.012Figueira E Branco D Antunes SC Gonçalves F Freitas R Are metallothioneins equally good biomarkers of metal and oxidative stress? Ecotoxicol Environ Saf 201284185 90 10.1016/j.ecoenv.2012.07.01222854745Open DOISearch in Google Scholar

126Mijošek T, Filipović MV, Dragun Z, Ivanković D, Krasnići N, Erk M, Gottstein S, Lajtner J, Sertić Perić, M, Matoničkin Kepčija, R. Comparison of electrochemically determined metallothionein concentrations in wild freshwater salmon fish and gammarids and their relation to total and cytosolic metal levels. Ecol Indicat 2019;105:188-98. doi: 10.1016/j. ecolind.2019.05.069Mijošek T Filipović MV Dragun Z Ivanković D Krasnići N Erk M Gottstein S Lajtner J Sertić Perić M Matoničkin Kepčija, R Comparison of electrochemically determined metallothionein concentrations in wild freshwater salmon fish and gammarids and their relation to total and cytosolic metal levels Ecol Indicat 2019105188 98 10.1016/j.ecolind.2019.05.069Open DOISearch in Google Scholar

127Theocharis SE, Margeli AP, Koutselinis A. Metallothionein: a multifunctional protein from toxicity to cancer. Int J Biol Markers 2003;8:162-9. doi: 10.1177/172460080301800302Theocharis SE Margeli AP Koutselinis A Metallothionein: a multifunctional protein from toxicity to cancer Int J Biol Markers 20038162 9 10.1177/172460080301800302Open DOISearch in Google Scholar

128Cherian MG, Jayasurya A, Bay B-H. Metallothioneins in human tumors and potential roles in carcinogenesis. Mutat Res 2003;533:201-9. doi: 10.1016/j.mrfmmm.2003.07.013Cherian MG Jayasurya A Bay B-H Metallothioneins in human tumors and potential roles in carcinogenesis Mutat Res 2003533201 9 10.1016/j.mrfmmm.2003.07.01314643421Open DOISearch in Google Scholar

129Bay BH, Jin R, Huang J, Tan PH. Metallothionein as a prognostic biomarker in breast cancer. Exp Biol Med ( M a y w o o d ) 2 0 0 6 ; 2 3 1 : 1 5 1 6 - 2 1 . do i : 10.1177/153537020623100910Bay BH Jin R Huang J Tan PH Metallothionein as a prognostic biomarker in breast cancer Exp Biol Med ( M a y w o o d ) 2 0 0 6 ; 2 3 1 : 1 5 1 6 - 2 1 10.1177/15353702062310091017018874Open DOISearch in Google Scholar

130Krizkova S, Masarik M, Majzlik P, Kukacka J, Kruseova J, Adam V, Prusa R, Eckschlager T, Stiborova M, Kizek R. Serum metallothionein in newly diagnosed patients with childhood solid tumours. Acta Biochim Pol 2010;57:561-6. doi: 10.18388/abp.2010_2444Krizkova S Masarik M Majzlik P Kukacka J Kruseova J Adam V Prusa R Eckschlager T Stiborova M Kizek R Serum metallothionein in newly diagnosed patients with childhood solid tumours Acta Biochim Pol 201057561 6 10.18388/abp.2010_2444Open DOISearch in Google Scholar

131Siddiqui S, Singh A, Alia S, Yadav M, Pandey V, Sharma D. Metallothionein: potential therapeutic target for osteosarcoma. J Oncol Sci 2019;5:13-8. doi: 10.1016/j.jons.2019.02.002Siddiqui S Singh A Alia S Yadav M Pandey V Sharma D Metallothionein: potential therapeutic target for osteosarcoma J Oncol Sci 2019513 8 10.1016/j.jons.2019.02.002Open DOISearch in Google Scholar

132Mangelinck A, da Costa MEM, Stefanovska B, Bawa O, Polrot M, Gaspar N, Fromigué O. MT2A is an early predictive biomarker of response to chemotherapy and a potential therapeutic target in osteosarcoma. Sci Rep 2019;9:12301. doi: 10.1038/s41598-019-48846-2Mangelinck A da Costa MEM Stefanovska B Bawa O Polrot M Gaspar N Fromigué O MT2A is an early predictive biomarker of response to chemotherapy and a potential therapeutic target in osteosarcoma Sci Rep 2019912301 10.1038/s41598-019-48846-2670724031444479Open DOISearch in Google Scholar

133Kwon JM, Goate AM. The candidate gene approach. Alcohol Res Health 2000;24:164-8. PMCID: PMC6709736 Kwon JM Goate AM The candidate gene approach Alcohol Res Health 200024164 8 PMCID: PMC6709736Search in Google Scholar

134Witte JS, Visscher PM, Wray NR. The contribution of genetic variants to disease depends on the ruler. Nat Rev Genet 2014;15:765-76. doi: 10.1038/nrg3786Witte JS Visscher PM Wray NR The contribution of genetic variants to disease depends on the ruler Nat Rev Genet 201415765 76 10.1038/nrg3786441273825223781Open DOISearch in Google Scholar

135Goldstein DB. Common genetic variation and human traits. N Engl J Med 2009;360:1696-8. doi: 10.1056/NEJMp0806284Goldstein DB Common genetic variation and human traits N Engl J Med 20093601696 8 10.1056/NEJMp080628419369660Open DOISearch in Google Scholar

136Hardy J, Singleton A. Genomewide association studies and human disease. N Engl J Med 2009;360:1759-68. doi: 10.1056/NEJMra0808700Hardy J Singleton A Genomewide association studies and human disease N Engl J Med 20093601759 68 10.1056/NEJMra0808700342285919369657Open DOISearch in Google Scholar

137Manolio TA. Genomewide association studies and assessment of the risk of disease. N Engl J Med 2010;363:166-76. doi: 10.1056/NEJMra0905980Manolio TA Genomewide association studies and assessment of the risk of disease N Engl J Med 2010363166 76 10.1056/NEJMra090598020647212Open DOISearch in Google Scholar