gene polymorphisms in relation to diseases and trace element levels in humans

Authors and year of publication (reference No.)	Ethnicity	n	Study participants	Sample type	Findings
Shokrzadeh et al., 2019 (101)	Iranian	95	Men and women with gastric cancer	Leukocytes	SNP MT2A -5A/G increase the risk of gastric
		90	Control healthy men and women		adenocarcinoma

Bialkowska et al., 2018 (88)		197	Men with prostate cancer	Whole blood	No association was found between SNP MT2A -5A/
		197	Control men without prostate cancer		G and prostate cancer

Liu et al., 2017 (100)	Chinese	459	Women with breast cancer	Whole blood	SNP MT2A -5A/G was associated with different
		549	Control healthy women		types of breast cancer

		130	Men and women with AMD		AG genotype subjects had 5.5-fold higher risk for
Garcia et al., 2017 (97)	Spanish	96	Control healthy men and women	Whole blood	AMD; G allele was associated with dry form of AMD

Raudenska et al., 2017 (103)		70	Men and women with type 2 diabetes mellitus		No association was found between SNP MT2A -5A/
		80	Control healthy men and women		G and type 2 diabetes mellitus

		165	Men and women with DM
Hattori et al., 2016 (95)	Japanese	417	Men and women with CKD	Serum	GG genotype associated with CKD and AG genotype with DM; no association of MT2A -5A/G and HT
		2192	Healthy men and women

		130	Men and women with SIP		SNP MT2A -5A/G was related to SIP (Schneiderian
Starska et al., 2015 (80)		418	Control men and women without head or neck tumour		papilloma); G allele increased 7.7-fold occurrence of SIP (Schneiderian papilloma); SNP MT2A -5A/G was associated with SIP phenotype
	Polish	117	Men and women with SIP	Tissue of nasal cavities or	Heterozygotes vs. homozygotes had increased risk
Starska et al., 2015 (84)		132	Control men and women with normal sinonasal mucosa	paranasal sinuses	of SIP
		323	Men and women with laryngeal cancer		AG genotype subjects had 1.6-fold higher risk for
Starska et al., 2014 (81)		418	Control healthy men and women		laryngeal cancer development; Association between SNP MT2A -5A/G and tumour aggressiveness

Kizeslak et al., 2014 (82)		534	Women with ductal breast cancer		SNP MT2A -5A/G was associated with ductal breast
	Polish	556	Control healthy women	Whole blood	cancer

Kiześlak et al., 2013 (86)	Polish	412	Men with prostate cancer		AG genotype had higher risk for occurrence of
		67	Control men without prostate cancer		prostate cancer

Forma et al., 2012 (87)	Polish	358	Men with prostate cancer	Prostate tissue	SNP MT2A -5A/G was associated with prostate
		406	Control men without prostate cancer		cancer and Gleason score

Kayaalty et al., 2011 (92)	Turkish	354	Healthy men and women	Whole blood	SNPMT24 -5A/G was associated with longevity

Hayashi et al., 2006 (96)	Japanese	37	Patients with SALS	Whole blood	No association between SNP MT2A -5A/G and
		206	Control healthy men and women		SALS and progression rate

Association between the rs28366003 (MT2A -5A/G) single nucleotide polymorphism and element concentrations in humans

Authors and year of publication (reference No.)					MT2A genotype
	Ethnicity	n	Study participants	Sample type	AA	AG	GG	Findings
As concentrations (μg/g creatine)
Stajnko et al., 2019 (99)	Croatian	136	Pregnant women	Urine	3.07*	4.58*^.§		No differences between genotypes

Gonzalez-et al., 2018 Martinez, (102)	Colombian	101	Men and women	Urine	(Not available)			No and association SNP MT2between A -5A/G As

Cd concentrations (μg/L* or μg/kg)

				Maternal blood	0.87±0.99*	0.73±0.60*^,§
Sekovanić et al.,	Croatian	268	Mother-newborn pairs	Cord blood	0.06±0.03*	0.05±0.03*^,§		No difference in either
2018(4)				Placenta	10.1±5.1	8.80±3.70^§		sample between genotypes

Hattori et al., 2016 (95)	Japanese	2774	Men and women	Serum	(Graphical illustration: Cd = 0.001*)			No differences between genotypes

Adams et al, 2015 (104)	US	321	Men and women	Urine	(Graphical illustration)			↓Cd in urine of G allele carriers

Starska et al., 2015 (84)	Polish	117	Men and women with SIP		116±79	376±126	393	AG vs. AA genotype ↑Cd in SIP samples; no association between Cd and SNP MI2A -5A/G in control samples
Starska et al., 2015 (84)	Polish	132	Control men and women with normal sinonasal mucosa	Tissue of nasal or paranasal sinuses (dry)	62.2±41.2	96.2±57.1	-

		323	Men and women with SCC		198±87	369±128	509±57	AG vs. AA genotype ↑Cd in
Starska et al., 2014 (85)	Polish	116	Control men and women with normal laryngeal mucosa	Tissue of laryngeal mucosa (dry)	87.2±32.2	113±26	117	both sample types; GG vs. AA and AG vs. GG genotype ↑Cd in SCC samples

Krzeslak et al., 2013 (86)	Polish	412	Men with prostate cancer	Prostate tissue (dry)	720±330	970±460	1090±220	AG vs. AA genotype ↑Cd in both sample types; GG vs. AA genotype ↑Cd in prostate cancer samples

Tekin et al, 2012				Maternal blood	1.60±0.94*	2.54±2.72*		AG vs. AA genotype \|Cd in
	Turkish	95	Mother-newborn pairs	Cord blood	0.95±0.32*	0.98±0.28*		maternal blood and ↓Cd in
				Placenta	20.8±19.7	8.65±6.70		placenta

Kayaalti et al, 2011 (91)	Turkish	616	Men and women	Whole blood	1.60±1.44*	2.09±1.85*	5.98±4.38*	G allele carriers ↑Cd

Kayaalti et al, 2010 (94)	Turkish	114	Men and women	Kidney samples (dry)	87.7±62.9†	151±60†	153f	↑Cd in G allele carriers

Pb concentrations (μg/L*or μg/kg)

				Maternal blood	13.7±6.6*	12.0±3.6*^,§
Sekovanić et al., 2018(4)	Croatian	268	Mother-newborn pairs	Cord blood	8.3±5.5*	7.1±4.0*-s		No difference in either sample between genotypes
				Placenta	6.9±4.9	5.5±2.8^§

Yang et al, 2017 (105)	Thai	677	Men and women	Whole blood	122±122*	105±113*	-	No differences between genotype

				Maternal blood	3.53±1.43*	5.13±2.79*	-
Tekin et al, 2012 (901	Turkish	91	Mother-newborn pairs	Cord blood	2.42±1.00*	2.94±1.49*	-	AG vs. AA genotype ↑ Pb in maternal blood
				Placenta	7.79±2.55	9.75±4.14	-

Krzeslaketal, 2013 (86)		412	Men with prostate cancer		3.11±1.27†	4.66±1.82†	5.11±2.52†	GG vs. AA genotype ↑Pb in
	Polish	67	Control men without prostate cancer	Prostate tissue (dry)	1.67±0.61f	1.72±0.67f	-	prostate cancer

Kayaalti et al, 2011 (91)	Turkish	616	Men and women	Plasma	30.1±13.9*	32.9±14.9*	50.4±11.5*	G allele carriers ↑Pb

Hg concentrations (μg/L*or μg/kg)

				Maternal blood	13.7±6.6*	12.0±3.6*s
Sekovanić et al., 2018(4)	Croatian	268	Mother-newborn pairs	Cord blood	8.3±5.5*	7.1±4.0*^,§		No difference in either sample between genotypes
				Placenta	6.9±4.9	5.5±2.8^§

Wang et al., 2012	_TTC	239	Men and women	Urine	1.03*	0.76*	0.34*	No difference between
(106)		247	Men and women	Hair	440	390	430	genotypes

Fe concentrations (mg/L*or mg kg^-1)

				Maternal blood	422±61*	418±56*^,§
Sekovanić et al., 2018(4)	Croatian	268	Mother-newborn pairs	Cord blood	552±61*	539±57^*,§		G allele carriers (AG+GG) vs. AA genotype ↓Fe in placenta
				Placenta	83±22	74±18^§

				Maternal blood	343±89*	373±103*	-
Tekin et al, 2012	Turkish	95	Mother-newborn pairs	Cord blood	271±130*	456±214*	-	AG vs. AA genotype ↑Fe in cord blood
				Placenta	527±194	624±162	-

Zn concentrations (mg/L*or mg kg^-1)

				Maternal blood	5.58±0.92*	5.51±0.82*^,§
Sekovanić et al., 2018(4)	Croatian	268	Mother-newborn pairs	Cord blood	2.78±0.46*	2.58±0.53*^,§		No difference in either sample between genotypes
				Placenta	13.7±3.0	13.4±1.8^§

		70	Men and women with diabetics		(Graphical illustration: Zn= 3* in AG vs. ~ 7.5* in AA)			AG vs. AA genotype ↓Zn in blood in diabetics
Raudenskaet al., 2017(103)	Czech	80	Control healthy men and women	Whole blood	(Graphical illustration: Zn= 5* in AG vs. ~ 6* in AA)			no association between Zn and SNP MT2A -5A/G in the control samples

Hattori et al., 2016 (95)	Japanese	2774	Men and women	Serum	(Graphical illustration: Zn = 0.850*)			No differences between genotypes

Adams et al, 2015 (104)	US	321	Men and women	Urine	(Graphical illustration)			↓Zn in urine of G allele carriers

		117	Men and women with SIP	Tissue of nasal cavities or paranasal sinuses (dry)	52.2±41.2	127±76	136	AG vs. AA genotype ↑Zn in SIP tissue samples;
Starska et al., 2015 (84)	Polish	132	Control men and women with normal sinonasal mucosa		199±44	204±52	-	No association between Zn and SNPMT24 -5A/G in control samples

		323	Men and women with SCC		86.4±38.1	184±57	194±74	AG vs. AA genotype ↑Zn in
Starska et al., 2014 (85)	Polish	116	Control men and women with normal laryngeal mucosa	Tissue of laryngeal mucosa	97.6±30.0	133±27	129	both sample types; GG vs. AA genotype ↑Zn in SCC samples

Krzeslak et al., 2013 (86)		412	Men with prostate cancer		135±48	239±80	243.7±64.4	AG vs. AA genotype ↑Zn in both sample types; GG vs.
	Polish	67	Control men without prostate cancer	Prostate tissue (dry)	485±119	927±317		AA genotype \|Zn in cancer samples

				Maternal blood	4.33±1.13*	4.82±1.44*	-
Tekin et al, 2012 (89)	Turkish	95	Mother- newborn pairs	Cord blood	1.32±0.55*	1.48±0.53*	-	No difference between genotypes
				Placenta	50.5±10.1	46.1±7	-

Kayaaltietal,2011(91)	Turkish	616	Men and women	Plasma	1.01±0.48*	0.84±0.50*	0.39±0.33*	G allele carriers ↓Zn

Kayaalti et al., 2010 (94)	Turkish	114	Men and women	Kidney tissue (dry)	180.2±84.6	192±115	142	No difference between genotypes

Cu concentrations (mg/L*or mg kg^-1)

				Maternal blood	1.52±0.30*	1.53±0.09*^§
Sekovanić et al., 2018(4)	Croatian	268	Mother-newborn pairs	Cord blood	0.59±0.09*	0.58± 0.12*^,§		No difference in either sample between genotypes
				Placenta	0.78±0.18	0.74± 0.08^§

Adams et al, 2015 (104)	US	321	Men and women	Urine	(	Graphical illustration)		↓Cu in urine of G allele carriers

		117	Men and women with SIP	Tissue of nasal cavities or paranasal sinuses (dry)	24.2±13.6	27.1±11.6	26.2	No differences between
Starska et al., 2015 (84)	Polish	132	Control men and women with normal sinonasal mucosa		11.0±2.98	17.2±5.2	-	genotypes in SIP tissue samples; AG vs. AA genotype ↑Cu in control samples

		323	Men and women with SCC		14.4±7.83	26.6±12.5	29.7±0.72	AG vs. AA genotype \|Cu in
Starska et al., 2014 (85)	Polish	116	Control men and women with normal laryngeal mucosa	Tissue of laryngeal mucosa	9.85±4.10	12.7±3.56	11.5	both sample types; GG vs. AA genotype \|Cu in SCC samples

		412	Men with prostate cancer		10.3±4.2	21.1±9.6	25.6±5.8	AG vs. AA genotype
Krzeslak et al., 2013 (86)	Polish	67	Control men without prostate cancer	Prostate tissue (dry)	2.9±1.3	7.6±2.9	-	↑Cu in both sample types; GG vs. AA genotype ↑ Cu in cancer samples

				Maternal blood	1.67±0.34*	1.84±0.50*	-
Tekin (89) et al, 2012	Turkish	95	Mother-newborn pairs	Cord blood	0.69±0.25*	0.69±0.28*	-	No difference genotypes between
				Placenta	5.90±2.59	6.63±1.73	-

Kayaalti et al., 2011 (91)	Turkish	616	Men and women	Plasma	1.04±0.44*	1.02±0.52*	0.91±0.37*	No difference genotypes between

Kayaalti et al., 2010(94)	Turkish	114	Men and women	Kidney tissue (dry)	17.2±16.9	15.3±10.6	31.9	No difference genotypes between

Genotype frequencies of the rs10636 (MT2A +838G/C) single nucleotide polymorphism in humans

Authors and year of publication (reference No.)	Ethnicity	n	Study participants	Genotype frequencies (%)
				GG	GC	CC
Yang et al., 2017 (105)	Thai	677	Men and women	52.4	41.6	6.0

Liu et al., 2017 (100)	Chinese	459	Women with breast cancer	52.5	37.5	11.8
		549	Control healthy women	52.8	40.8	6.4

García et al., 2017	Spanish	130	Men and women with AMD	56.9	36.9	6.2
(97)		96	Control healthy men and women	67.7	27.1	5.2

Fernandes (119) et al., 2016	Brazilian	221	Workers in car battery factories	62.0	32.0	6.0

Adams et al., 2015	US	170	Premenopausal women	54.0	42.0	4.0
(104)		151	Men and women	62.0	34.0	4.0

		130	Men and women with SIP	44.6	43.1	12.3
Starska et al., 2015 (80)	Polish	418	Control men and women without head and neck tumours	50.9	41.2	7.9

Starska et al., 2014	Polish	323	Men and women with laryngeal cancer	45.8	46.1	8.1
(81)		418	Control volunteers (men and women)	50.9	41.2	7.9

Yang et al., 2014	Chinese	287	Men and women with CHD	46.0	45.3	8.7
(117)		226	Control healthy men and women	57.1	36.7	6.2

Krześlak et al., 2014		534	Women with breast cancer	57.1	38.4	4.5
(82)	Polish	556	Control healthy women	50.3	45.5	4.2

Woods et al., 2013		163	Boys average age 10 years	61.3	30.7	8.0
(116)	Portuguese	167	Girls average age 10 years	59.9	33.5	6.6

Chen et al., 2012 (118)	Chinese	465	Men and women	52.3	39.5	8.2

Wang et al., 2012 (106)	US	464	Men and women	54.1	36.8	9.1

Forma et al., 2012	Polish	358	Men with prostate cancer	48.9	43.3	7.8
(87)		406	Control men without prostate cancer	52.0	40.0	8.0

Gundacker 2009 (120) et al.,	Austrian	180	Men and women	58.4	33.3	8.3

Yang et al., 2008	Chinese	182	Men and women with DM	46.7	42.9	10.4
(115)		196	Control volunteers (men and women)	42.9	47.4	9.70

		100	CS patients	73.0	22.0	5.0
Giacconi et al., 2007 (113)	Italian	188	CS patients without cerebrovascular episodes	66.0	30.0	4.0
		218	Control elderly volunteers	56.0	37.0	7.0

Association between the rs1610216 SNP (MT2A -209A/G) single nucleotide polymorphism and human diseases

Authors and year of publication (reference No.)	Ethnicity	n	Study participants	Sample type	Findings
		130	Men and women with SIP	Tissue of nasal cavities or	No association between SNP MT2A
Starska et al., 2015 (80)	Polish	418	Control men and women without head and neck tumours	paranasal sinuses	-209A/G and SIP

		323	Men and women with laryngeal cancer	Tissue of squamous cell	No association between SNPMT24
Starska et al., 2014(81)		418	Control volunteers (men and women)	laryngeal cancer	-209A/G and development of laryngeal cancer

Krzeslak et al., 2014(82)	Polish	534	Women with breast cancer	Whole blood	No associations between SNP MT2A
		556	Control healthy women		-209A/G and breast cancer

Forma et al, 2012 (87)	Polish	358	Men with prostate cancer	Whole blood	No association between SNPMT24
		406	Control men without prostate cancer		-209 A/G and prostate cancer

		142	Patients with CAD		Positive association between G allele carriers
Kozarova et al., 2012	Bulgarian	101	Patients with DM	Leukocytes	and DM;
(114)		61	Control healthy volunteers		No association between SNF MT2A -209 A/G and CAD

		100	CS patients
Giacconi et al., 2007 (113)	Italian	188	CS patients without cerebrovascular episodes	Blood	No association between SNPMT24 -209 A/G and CS or cerebrovascular episodes
		218	Control elderly volunteers

Giacconi et al., 2005 (112)	Italian	91	Men and women with carotid stenosis	Whole blood	No association between SNF MT2A -209A/G and hypertension; higher risk of
		188	Control elderly men and women		ischaemic cardiomyopathy and hyperglycaemia in AA genotype subjects

Genotype frequencies of the rs1610216 (MT2A −209A/G) single nucleotide polymorphism in humans

Authors and year of publication (reference No.)				Genotype frequencies (%)
	Ethnicity	n	Study population	AA	AG	GG
Starska et al., 2015		130	Men and women with SIP	73.8	25.4	0.8
(80)	Polish	418	Control men and women without head and neck tumours	73.9	25.3	0.8

Starska et al., 2014	Polish	323	Men and women with laryngeal cancer	73.4	26.0	0.6
(81)		418	Control healthy men and women	73.9	25.3	0.8

Krześlak et al.,	Polish	534	Women with breast cancer	76.4	23.4	0.2
2014 (82)		556	Control healthy women	72.3	27.5	0.2

Forma et al., 2012	Polish	358	Men with prostate cancer	71.8	27.6	0.6
(87)		406	Control men without prostate cancer	72.0	27.8	0.2

		142	Patients with CAD	89.2	9.4	1.4
Kozarova 2012 (114et ) al.,	Bulgarian	101	Patients with DM	69.7	28.3	2.0

		61	Control healthy volunteers	90.5	0.0	9.5
		100	CS patients	75.0	24.0	1.0

Giacconi et al., 2007 (113)	Italian	188	CS patients without cerebrovascular episodes	73.0	25.0	2.0
		218	Control elderly volunteers	71.0	26.0	3.0

Giacconi et al.,	Italian	91	Men and women with carotid stenosis	86.0	14.0	0.0
2005 (112)		188	Control elderly men and women	70.2	26.1	3.7

Association between the rs1610216 (MT2A -209A/G) single nucleotide polymorphism and element concentrations in humans

Authors and year of publication (reference No.)					MT2A genotype
	Ethnicity	n	Study participants	Sample type	AA	AG	GG	Findings

Zn concentrations (mg/L)
Giacconi et al., 2005 (112)	Italian	91	Patients: elderly men and women with type 2 diabetes and carotid stenosis	Plasma	0.77±0.15	0.88±0.18^.§		↓Zn in AA vs. AG+GG in patients; in AA genotype subjects ↓Zn in patients 188 Control: healthy elderly men and vs. control
Giacconi et al., 2005 (112)	Italian	188	Control: healthy elderly men and vs. control women		0.87±0.25	0.88±0.15^.§

Association between the rs10636 (MT2A +838G/C) single nucleotide polymorphism and human diseases

Authors and year of publication (reference No.)	Ethnicity	n	Study participants	Sample type	Findings
Liu et al., 2017 (100)	Chinese	459	Women with breast cancer	Whole blood	SNPMT2A +838 G/C was associated with breast cancer
Liu et al., 2017 (100)	Chinese			Whole blood	SNPMT2A +838 G/C was associated with breast cancer
		549	Control healthy women

Garcia et al., 2017 (97)	Spanish	130	Men and women with AMD	Whole blood	No association between SNPMT2A +838 G/C and AMD
Garcia et al., 2017 (97)	Spanish			Whole blood	No association between SNPMT2A +838 G/C and AMD
		96	Control healthy men and women

Starska et al., 2015 (80)	Polish	130	Men and women with SIP	Tissue of nasal cavities or paranasal sinuses	No association between SNP MT2A +838G/C and SIP
Starska et al., 2015 (80)	Polish			Tissue of nasal cavities or paranasal sinuses	No association between SNP MT2A +838G/C and SIP
		418	Control men and women without head and neck tumours

Starska et al., 2014 (81)	Polish	323	Men and women with laryngeal cancer	Tissue of squamous cell	No association between SNP MT2A +838G/C
Starska et al., 2014 (81)	Polish			Tissue of squamous cell	No association between SNP MT2A +838G/C
		418	Control heathy men and women	laryngeal cancer	and development of laryngeal cancer

Yang et al., 2014 (117)	Chinese	287	Men and women with CHD	Blood leukocytes	SNPMT2A +838G/C was associated with CHD
Yang et al., 2014 (117)	Chinese			Blood leukocytes	SNPMT2A +838G/C was associated with CHD
		226	Control healthy men and women

Krzeslak et al., 2014 (82)	Polish	534	Women with breast cancer	Whole blood	No associations between SNPMT24 +838G/C and breast cancer
Krzeslak et al., 2014 (82)	Polish			Whole blood	No associations between SNPMT24 +838G/C and breast cancer
		556	Control healthy women

Yang et al., 2008 (115)	Chinese	397	Men and women with DM	Whole blood	SNPMT24 +838G/C was associated with higher risk for hyperlipidemia and incidence of DM with neuropathy
Yang et al., 2008 (115)	Chinese			Whole blood
		454	Control men and women

Giacconi et al., 2007 (113)	Italian	100	CS patients	Blood	SNPMT24 +838G/C promote the progression of carotid artery disease to CS

		188	CS patients without cerebrovascular episodes

		218	Control elderly volunteers

Genotype frequencies of the rs28366003 (MT2A −5A/G) single nucleotide polymorphism in humans

Authors and year of publication (reference No.)				Genotype frequencies (%)
	Ethnicity	n	Study participants	AA	AG	GG
Stajnko et al., 2019 (99)	Croatian	136	Pregnant women	93.0^#	7.0^$
Stajnko et al., 2019 (99)	Slovenian	176	Non-pregnant women	95.0^#	5.0^$

Shokrzadeh et al., 2019 (101)	Iranian	95	Men and women with gastric cancer	46.4	41.0	12.6
Shokrzadeh et al., 2019 (101)	Iranian	90	Control healthy men and women	57.8	37.8	4.4

Sekovanić et al., 2018 (4)	Croatian	268	Mother-newborn pairs	94.0	6.0	^§

González-al., 2018 (Martínez 102) et	Colombian	101	Men and women	53.4	43.6	3.0

Białkowska et al., 2018	Polish	197	Men with prostate cancer	90.9	9.1^§
(88)		197	Control men without prostate cancer	89.3	10.7^§

Yang et al., 2017 (105)	Thai	677	Men and women	79.5	20.5	0.0

Liu et al., 2017 (100)	Chinese	459	Women with breast cancer (various types)	82.3	15.3	2.4
		549	Control healthy women	92.5	7.5	0.0

		130	Men and women with AMD	88.5	11.5	0.0
García et al., 2017 (97)	Spanish	96	Control healthy men and women	97.9	2.1	0.0

Raudenska et al., 2017 (103)		70	Men and women with type 2 diabetes mellitus	88.6	8.6	0.0
	Czech	80	Control healthy men and women	86.3	13.7	0.0

Hattori et al., 2016 (95)	Japanese	2774	Men and women	81.8	17.4	0.8

Adams et al., 2015 (104)	US	170	Premenopausal women	88.0	12.0	0.0
		151	Men and women	84.0	15.0	1.0

		130	Men and women with SIP	75.4	23.8	0.8
Starska et al., 2015 (80)	Polish	418	Control men and women without head or neck tumour	95.5	4.1	0.0

		117	Men and women with SIP	76.1	23.1	0.8
Starska et al., 2015 (84)	Polish	132	Control men and women with normal sinonasal mucosa	87.9	12.1	0.0

		323	Men and women with SCC	89.2	9.9	0.9
Starska et al., 2014 (85)	Polish	116	Control men and women with normal laryngeal mucosa	84.5	14.6	0.9

		323	Men and women with laryngeal cancer	89.2	9.9	0.9
Starska et al., 2014 (81)	Polish	418	Control healthy men and women	84.0	16.0	0.0

Krześlak et al., 2014 (82)		534	Women with ductal breast cancer	87.1	12.3	0.6
	Polish	556	Control healthy women	92.8	7.2	0.0

Krześlak et al., 2013 (86)		412	Men with prostate cancer	76.0	21.1	2.9
	Polish	67	Control men without prostate cancer	88.0	12.0	0.0

Wang et al., 2012 (106)	US	239	Men and women	89.1	10.1	0.8

		358	Men with prostate cancer	76.8	20.9	2.3
Forma et al., 2012 (87)	Polish	406	Control men without prostate cancer	88.9	10.6	0.5

Tekin et al., 2012 (89)	Turkish	95	Mother-newborn pairs	87.4	12.6	0.0

Tekin et al., 2012 (90)	Turkish	91	Mother-newborn pairs	86.8	13.2	0.0

Kayaalti et al., 2011 (91)	Turkish	616	Men and women	86.6	12.8	0.6

Kayaalti et al., 2011 (92)	Turkish	354	Men and women	90.4	9.0	0.6

McElroy et al., 2010 (98)	US	142	Black women	97.9	2.1	-
		149	White women	87.3	12.8	-

Kayaalti et al., 2010 (93)	Turkish	122	Men and women (kidney samples)	88.5	10.7	0.8
		186	Men and women (blood samples)	86.0	13.4	0.6

Kayaalti et al., 2010 (94)	Turkish	114	Men and women (kidney samples)	87.7	11.4	0.9

Hayashi et al., 2006 (96)		37	Patients with SALS	75.7	24.3	0.0
	Japanese	206	Control healthy men and women	82.5	17.0	0.5

Association between the rs10636 (MT2A +838G/O sinslenucleotide nolvmornhism and element concentrations in humans

Authors and year of publication (reference No.)	Ethnicity	n	Study participants	Sample type	MT2A genotype			Findings
						GG	GC	CC

		Cd concentrations (μg/L)
Adams et al., 2015 (104)	US	321	Men and women	Urine	(Graphical illustration)			↓Cd in urine of C allele carriers

Chen et al, 2012 (118)	Chinese	311	Women exposed to Cd	Blood/ Urine	(Graphical illustration)			Trends of ↓Cd in blood of C allele carriers in highly polluted area; no difference of Cd in urine
			Pb concentrations (μg/L)
Yang et al., 2017 (105)	Thai	677	Men and women	Whole blood	116±119	121±121	124±141	No difference between genotypes

Fernandes et al, 2016(119)	Brazilian	221	Workers in car battery factories	Whole blood	(Graphical illustration)			C allele carriers ↓Pb in blood

Gundacker et al., 2009 (120)	Austrian	122	Men and women	Whole blood	20.2	21.3	16.9	CC genotype had ↓ Pb in blood
			Hg concentrations (μg/Lor μg/kg*)
Woods et al, 2013(116)	Portuguese	96	Boys of avg. age 10 years	Urine	2.17±2.15	2.16±2.16^§		No difference between genotypes

Wang et al., 2012 (106)	US	464	Men and women	Urine	1.04	1.04	1.22	No difference between genotypes

		473	Men and women	Hair	500*	430*	570*
			Fe concentrations (mg/L)
Giacconi et al., 2007(113)	Italian	288	CS patients	Plasma	1.11±0.47	0.99±0.32^§		C allele carriers had ↓Fe in plasma

				Erythrocytes	505±270	506±102^§
			Zn concentrations (mg/L)
Adams et al, 2015 (104)	US	321	Men and women	Urine	(Graphical illustration)			↓Zn in urine of C allele carriers

Giacconi et al, 2007 (113)	Italian	288	Patients with CS	Plasma	0.71±0.17	0.74±0.15^§		C allele carriers ↑Zn in erythrocytes

				Erythrocytes	7.4±2.6	8.5±2.0^§
			Cu concentrations (mg/L)
Adams et al, 2015 (104)	US	321	Men and women	Urine	(Graphical illustration)			↓Cu in urine of C allele carriers

Giacconi et al, 2007 (113)	Italian	288	Patients with CS	Plasma	1.07±0.29	l.ll±0.24^§		C allele carriers ↑Cu in erythrocytes

				Erythrocytes	0.52±0.11	0.56±0.13^§

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