Exenatide improves antioxidant capacity and reduces the expression of LDL receptors and PCSK9 in human insulin-secreting 1.1E7 cell line subjected to hyperglycemia and oxidative stress Article Category: Original Article Publié en ligne: 20 févr. 2022 Pages: 16 - 23 Reçu: 01 janv. 2021 Accepté: 16 juil. 2021 © 2022 Łukasz Bułdak et al., published by Sciendo This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Fig. 1 The impact of exenatide on the level of expression of p22 (a), catalase (b), glutathione peroxidase (c) and superoxide dismutase 1 (d). Data are expressed as means ± SEM. Asterisks indicate the level of statistical significance: * - p<0.05, ** - p<0.01 Fig. 2 The impact of exenatide on the level of expression of inducible nitric oxide (a), and the concentration of nitrite in culture media (b). Data are expressed as means ± SEM. Asterisks indicate the level of statistical significance: * - p<0.05, ** - p<0.01 Fig. 3 The impact of exenatide on the concentration of insulin in culture media (a), the level of expression of LDL receptor (b) and PCSK9 (c). Data are expressed as means ± SEM. Asterisks indicate the level of statistical significance: * - p<0.05, ** - p<0.01