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Exenatide improves antioxidant capacity and reduces the expression of LDL receptors and PCSK9 in human insulin-secreting 1.1E7 cell line subjected to hyperglycemia and oxidative stress

Łukasz Bułdak

Łukasz Bułdak

Department of Internal Medicine and Clinical Pharmacology, School of Medicine in Katowice, Medical University of SilesiaKatowice, Poland
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Bułdak, Łukasz
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Estera Skudrzyk

Estera Skudrzyk

Department of Internal Medicine and Clinical Pharmacology, School of Medicine in Katowice, Medical University of SilesiaKatowice, Poland
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Skudrzyk, Estera
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Grzegorz Machnik

Grzegorz Machnik

Department of Internal Medicine and Clinical Pharmacology, School of Medicine in Katowice, Medical University of SilesiaKatowice, Poland
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Machnik, Grzegorz
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Aleksandra Bołdys

Aleksandra Bołdys

Department of Internal Medicine and Clinical Pharmacology, School of Medicine in Katowice, Medical University of SilesiaKatowice, Poland
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Bołdys, Aleksandra
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Rafał Jakub Bułdak

Rafał Jakub Bułdak

Institute of Medical Sciences, University of OpoleOpole, Poland
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Bułdak, Rafał Jakub
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Bogusław Okopień

Bogusław Okopień

Department of Internal Medicine and Clinical Pharmacology, School of Medicine in Katowice, Medical University of SilesiaKatowice, Poland
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Okopień, Bogusław
  
Feb 20, 2022
Exenatide improves antioxidant capacity and reduces the expression of LDL receptors and PCSK9 in human insulin-secreting 1.1E7 cell line subjected to hyperglycemia and oxidative stress's Cover Image
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Article Category: Original Article
Published Online: Feb 20, 2022
Page range: 16 - 23
Received: Jan 01, 2021
Accepted: Jul 16, 2021
DOI: https://doi.org/10.2478/ahem-2021-0037
Keywords
© 2022 Łukasz Bułdak et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1

The impact of exenatide on the level of expression of p22 (a), catalase (b), glutathione peroxidase (c) and superoxide dismutase 1 (d). Data are expressed as means ± SEM. Asterisks indicate the level of statistical significance: * - p<0.05, ** - p<0.01
The impact of exenatide on the level of expression of p22 (a), catalase (b), glutathione peroxidase (c) and superoxide dismutase 1 (d). Data are expressed as means ± SEM. Asterisks indicate the level of statistical significance: * - p<0.05, ** - p<0.01

Fig. 2

The impact of exenatide on the level of expression of inducible nitric oxide (a), and the concentration of nitrite in culture media (b). Data are expressed as means ± SEM. Asterisks indicate the level of statistical significance: * - p<0.05, ** - p<0.01
The impact of exenatide on the level of expression of inducible nitric oxide (a), and the concentration of nitrite in culture media (b). Data are expressed as means ± SEM. Asterisks indicate the level of statistical significance: * - p<0.05, ** - p<0.01

Fig. 3

The impact of exenatide on the concentration of insulin in culture media (a), the level of expression of LDL receptor (b) and PCSK9 (c). Data are expressed as means ± SEM. Asterisks indicate the level of statistical significance: * - p<0.05, ** - p<0.01
The impact of exenatide on the concentration of insulin in culture media (a), the level of expression of LDL receptor (b) and PCSK9 (c). Data are expressed as means ± SEM. Asterisks indicate the level of statistical significance: * - p<0.05, ** - p<0.01
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Life Sciences, Molecular Biology, Microbiology and Virology, Medicine, Basic Medical Science, Immunology
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