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Postępy Higieny i Medycyny Doświadczalnej
Volume 76 (2022): Issue 1 (January 2022)
Open Access
Exenatide improves antioxidant capacity and reduces the expression of LDL receptors and PCSK9 in human insulin-secreting 1.1E7 cell line subjected to hyperglycemia and oxidative stress
Łukasz Bułdak
Łukasz Bułdak
,
Estera Skudrzyk
Estera Skudrzyk
,
Grzegorz Machnik
Grzegorz Machnik
,
Aleksandra Bołdys
Aleksandra Bołdys
,
Rafał Jakub Bułdak
Rafał Jakub Bułdak
and
Bogusław Okopień
Bogusław Okopień
| Feb 20, 2022
Postępy Higieny i Medycyny Doświadczalnej
Volume 76 (2022): Issue 1 (January 2022)
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Article Category:
Original Article
Published Online:
Feb 20, 2022
Page range:
16 - 23
Received:
Jan 01, 2021
Accepted:
Jul 16, 2021
DOI:
https://doi.org/10.2478/ahem-2021-0037
Keywords
Exenatide
,
GLP-1
,
pancreatic beta cell
,
oxidative stress
,
insulin
,
PCSK9
,
LDL receptor
© 2022 Łukasz Bułdak et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Fig. 1
The impact of exenatide on the level of expression of p22 (a), catalase (b), glutathione peroxidase (c) and superoxide dismutase 1 (d). Data are expressed as means ± SEM. Asterisks indicate the level of statistical significance: * - p<0.05, ** - p<0.01
Fig. 2
The impact of exenatide on the level of expression of inducible nitric oxide (a), and the concentration of nitrite in culture media (b). Data are expressed as means ± SEM. Asterisks indicate the level of statistical significance: * - p<0.05, ** - p<0.01
Fig. 3
The impact of exenatide on the concentration of insulin in culture media (a), the level of expression of LDL receptor (b) and PCSK9 (c). Data are expressed as means ± SEM. Asterisks indicate the level of statistical significance: * - p<0.05, ** - p<0.01