Screening of Potential Probiotic Lactobacillaceae and Their Improvement of Type 2 Diabetes Mellitus by Promoting PI3K/AKT Signaling Pathway in db/db Mice
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Abo El-Nasr NME, Saleh DO, Mahmoud SS, Nofal SM, Abdelsalam RM, Safar MM, El-Abhar HS. Olmesartan attenuates type 2 diabetes-associated liver injury: Cross-talk of AGE/RAGE/JNK, STAT3/SCOS3 and RAS signaling pathways. Eur J Pharmacol. 2020 May; 874:173010. https://doi.org/10.1016/j.ejphar.2020.173010Abo El-NasrNMESalehDOMahmoudSSNofalSMAbdelsalamRMSafarMMEl-AbharHSOlmesartan attenuates type 2 diabetes-associated liver injury: Cross-talk of AGE/RAGE/JNK, STAT3/SCOS3 and RAS signaling pathways2020May874173010https://doi.org/10.1016/j.ejphar.2020.173010Search in Google Scholar
Al-muzafar HM, Amin KA. Probiotic mixture improves fatty liver disease by virtue of its action on lipid profiles, leptin, and inflammatory biomarkers. BMC Complement Altern Med. 2017 Dec;17(1):43. https://doi.org/10.1186/s12906-016-1540-zAl-muzafarHMAminKAProbiotic mixture improves fatty liver disease by virtue of its action on lipid profiles, leptin, and inflammatory biomarkers2017Dec17143https://doi.org/10.1186/s12906-016-1540-zSearch in Google Scholar
Archer AC, Muthukumar SP, Halami PM.Lactobacillus fermentum mcc2759 and mcc2760 alleviate inflammation and intestinal function in high-fat diet-fed and streptozotocin-induced diabetic rats. Probiotics Antimicrob Proteins. 2021 Aug;13(4):1068–1080. https://doi.org/10.1007/s12602-021-09744-0ArcherACMuthukumarSPHalamiPMLactobacillus fermentum mcc2759 and mcc2760 alleviate inflammation and intestinal function in high-fat diet-fed and streptozotocin-induced diabetic rats2021Aug13410681080https://doi.org/10.1007/s12602-021-09744-0Search in Google Scholar
Awad WA, Hess C, Hess M. Re-thinking the chicken – Campylobacter jejuni interaction: A review. Avian Pathol. 2018 Jul;47(4):352–363. https://doi.org/10.1080/03079457.2018.1475724AwadWAHessCHessMRe-thinking the chicken – Campylobacter jejuni interaction: A review2018Jul474352363https://doi.org/10.1080/03079457.2018.1475724Search in Google Scholar
Barapatre A, Aadil KR, Tiwary BN, Jha H.In vitro antioxidant and antidiabetic activities of biomodified lignin from Acacia nilotica wood. Int J Biol Macromol. 2015 Apr;75:81–89. https://doi.org/10.1016/j.ijbiomac.2015.01.012BarapatreAAadilKRTiwaryBNJhaHIn vitro antioxidant and antidiabetic activities of biomodified lignin from Acacia nilotica wood2015Apr758189https://doi.org/10.1016/j.ijbiomac.2015.01.012Search in Google Scholar
Barros CP, Grom LC, Guimarães JT, Balthazar CF, Rocha RS, Silva R, Almada CN, Pimentel TC, Venâncio EL, Collopy Junior I, et al. Paraprobiotic obtained by ohmic heating added in whey-grape juice drink is effective to control postprandial glycemia in healthy adults. Food Res Int. 2021 Feb;140:109905. https://doi.org/10.1016/j.foodres.2020.109905BarrosCPGromLCGuimarãesJTBalthazarCFRochaRSSilvaRAlmadaCNPimentelTCVenâncioELCollopy JuniorIParaprobiotic obtained by ohmic heating added in whey-grape juice drink is effective to control postprandial glycemia in healthy adults2021Feb140109905https://doi.org/10.1016/j.foodres.2020.109905Search in Google Scholar
Beglari S, Khodagholi F, Gholami Pourbadie H, Iranbakhsh A, Rohani M. Biosorption and bioaccumulation of nickel by probiotic lactic acid bacteria isolated from human feces. Biorem J. 2022 Jun;0:1–12. https://doi.org/10.1080/10889868.2022.2086529BeglariSKhodagholiFGholami PourbadieHIranbakhshARohaniMBiosorption and bioaccumulation of nickel by probiotic lactic acid bacteria isolated from human feces2022Jun0112https://doi.org/10.1080/10889868.2022.2086529Search in Google Scholar
Belguesmia Y, Domenger D, Caron J, Dhulster P, Ravallec R, Drider D, Cudennec B. Novel probiotic evidence of lactobacilli on immunomodulation and regulation of satiety hormones release in intestinal cells. J Funct Foods. 2016 Jun;24:276–286. https://doi.org/10.1016/j.jff.2016.04.014BelguesmiaYDomengerDCaronJDhulsterPRavallecRDriderDCudennecBNovel probiotic evidence of lactobacilli on immunomodulation and regulation of satiety hormones release in intestinal cells2016Jun24276286https://doi.org/10.1016/j.jff.2016.04.014Search in Google Scholar
Cao R, Islamoglu H, Teskey G, Gyurjian K, Abrahem R, Onajole OK, Lun S, Bishai W, Kozikowski AP, Fraix MP, et al. The preclinical candidate indole-2-carboxamide improves immune responses to Mycobacterium tuberculosis infection in healthy subjects and individuals with type 2 diabetes. Int Microbiol. 2020 May; 23(2):161–170. https://doi.org/10.1007/s10123-019-00086-0CaoRIslamogluHTeskeyGGyurjianKAbrahemROnajoleOKLunSBishaiWKozikowskiAPFraixMPThe preclinical candidate indole-2-carboxamide improves immune responses to Mycobacterium tuberculosis infection in healthy subjects and individuals with type 2 diabetes2020May232161170https://doi.org/10.1007/s10123-019-00086-0Search in Google Scholar
Chapman CMC, Gibson GR, Rowland I. Health benefits of probiotics: are mixtures more effective than single strains? Eur J Nutr. 2011 Feb;50(1):1–17. https://doi.org/10.1007/s00394-010-0166-zChapmanCMCGibsonGRRowlandIHealth benefits of probiotics: are mixtures more effective than single strains?2011Feb501117https://doi.org/10.1007/s00394-010-0166-zSearch in Google Scholar
Chen P, Zhang Q, Dang H, Liu X, Tian F, Zhao J, Chen Y, Zhang H, Chen W. Screening for potential new probiotic based on probiotic properties and α-glucosidase inhibitory activity. Food Control. 2014 Jan;35(1):65–72. https://doi.org/10.1016/j.foodcont.2013.06.027ChenPZhangQDangHLiuXTianFZhaoJChenYZhangHChenWScreening for potential new probiotic based on probiotic properties and α-glucosidase inhibitory activity2014Jan3516572https://doi.org/10.1016/j.foodcont.2013.06.027Search in Google Scholar
Dang F, Jiang Y, Pan R, Zhou Y, Wu S, Wang R, Zhuang K, Zhang W, Li T, Man C. Administration of Lactobacillus paracasei ameliorates type 2 diabetes in mice. Food Funct. 2018;9(7):3630–3639. https://doi.org/10.1039/C8FO00081FDangFJiangYPanRZhouYWuSWangRZhuangKZhangWLiTManCAdministration of Lactobacillus paracasei ameliorates type 2 diabetes in mice20189736303639https://doi.org/10.1039/C8FO00081FSearch in Google Scholar
Dehghani F, Abdollahi S, Shidfar F, Clark CCT, Soltani S. Probiotics supplementation and brain-derived neurotrophic factor (BDNF): A systematic review and meta-analysis of randomized controlled trials. Nutr Neurosci. 2022 Aug;0:1–11. https://doi.org/10.1080/1028415X.2022.2110664DehghaniFAbdollahiSShidfarFClarkCCTSoltaniSProbiotics supplementation and brain-derived neurotrophic factor (BDNF): A systematic review and meta-analysis of randomized controlled trials2022Aug0111https://doi.org/10.1080/1028415X.2022.2110664Search in Google Scholar
Fonseca HC, de Sousa Melo D, Ramos CL, Dias DR, Schwan RF. Probiotic properties of lactobacilli and their ability to inhibit the adhesion of enteropathogenic bacteria to Caco-2 and HT-29 cells. Probiotics Antimicrob Proteins. 2021 Feb;13(1):102–112. https://doi.org/10.1007/s12602-020-09659-2FonsecaHCde Sousa MeloDRamosCLDiasDRSchwanRFProbiotic properties of lactobacilli and their ability to inhibit the adhesion of enteropathogenic bacteria to Caco-2 and HT-29 cells2021Feb131102112https://doi.org/10.1007/s12602-020-09659-2Search in Google Scholar
Gong L, Feng D, Wang T, Ren Y, Liu Y, Wang J. Inhibitors of α-amylase and α-glucosidase: Potential linkage for whole cereal foods on prevention of hyperglycemia. Food Sci Nutr. 2020 Dec;8(12): 6320–6337. https://doi.org/10.1002/fsn3.1987GongLFengDWangTRenYLiuYWangJInhibitors of α-amylase and α-glucosidase: Potential linkage for whole cereal foods on prevention of hyperglycemia2020Dec81263206337https://doi.org/10.1002/fsn3.1987Search in Google Scholar
Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, et al. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):506–514. https://doi.org/10.1038/nrgastro.2014.66HillCGuarnerFReidGGibsonGRMerensteinDJPotBMorelliLCananiRBFlintHJSalminenSThe International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic2014Aug118506514https://doi.org/10.1038/nrgastro.2014.66Search in Google Scholar
Hsieh PS, Ho HH, Hsieh SH, Kuo YW, Tseng HY, Kao HF, Wang JY.Lactobacillus salivarius AP-32 and Lactobacillus reuteri GL-104 decrease glycemic levels and attenuate diabetes-mediated liver and kidney injury in db/db mice. BMJ Open Diabetes Res Care. 2020 Apr;8(1):e001028. https://doi.org/10.1136/bmjdrc-2019-001028HsiehPSHoHHHsiehSHKuoYWTsengHYKaoHFWangJYLactobacillus salivarius AP-32 and Lactobacillus reuteri GL-104 decrease glycemic levels and attenuate diabetes-mediated liver and kidney injury in db/db mice2020Apr81e001028https://doi.org/10.1136/bmjdrc-2019-001028Search in Google Scholar
Huang Y, Wang X, Wang J, Wu F, Sui Y, Yang L, Wang Z.Lactobacillus plantarum strains as potential probiotic cultures with cholesterol-lowering activity. J Dairy Sci. 2013 May;96(5):2746–2753. https://doi.org/10.3168/jds.2012-6123HuangYWangXWangJWuFSuiYYangLWangZLactobacillus plantarum strains as potential probiotic cultures with cholesterol-lowering activity2013May96527462753https://doi.org/10.3168/jds.2012-6123Search in Google Scholar
Jomehzadeh N, Javaherizadeh H, Amin M, Saki M, Al-Ouqaili MTS, Hamidi H, Seyedmahmoudi M, Gorjian Z. Isolation and identification of potential probiotic Lactobacillus species from feces of infants in southwest Iran. Int J Infect Dis. 2020 Jul;96:524–530. https://doi.org/10.1016/j.ijid.2020.05.034JomehzadehNJavaherizadehHAminMSakiMAl-OuqailiMTSHamidiHSeyedmahmoudiMGorjianZIsolation and identification of potential probiotic Lactobacillus species from feces of infants in southwest Iran2020Jul96524530https://doi.org/10.1016/j.ijid.2020.05.034Search in Google Scholar
Kim S, Huang E, Park S, Holzapfel W, Lim SD. Physiological characteristics and anti-obesity effect of Lactobacillus plantarum K10. Korean J Food Sci Anim Resour. 2018 Jul;38(3):554–569. https://doi.org/10.5851/kosfa.2018.38.3.554KimSHuangEParkSHolzapfelWLimSDPhysiological characteristics and anti-obesity effect of Lactobacillus plantarum K102018Jul383554569https://doi.org/10.5851/kosfa.2018.38.3.554Search in Google Scholar
Kunduhoglu B, Hacioglu S. Probiotic potential and gluten hydrolysis activity of Lactobacillus brevis kt16-2. Probiotics Antimicrob Proteins. 2021 Jun;13(3):720–733. https://doi.org/10.1007/s12602-020-09723-xKunduhogluBHaciogluSProbiotic potential and gluten hydrolysis activity of Lactobacillus brevis kt16-22021Jun133720733https://doi.org/10.1007/s12602-020-09723-xSearch in Google Scholar
Li SC, Hsu WF, Chang JS, Shih CK. Combination of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis shows a stronger anti-inflammatory effect than individual strains in HT-29 cells. Nutrients. 2019 Apr;11(5):969. https://doi.org/10.3390/nu11050969LiSCHsuWFChangJSShihCKCombination of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis shows a stronger anti-inflammatory effect than individual strains in HT-29 cells2019Apr115969https://doi.org/10.3390/nu11050969Search in Google Scholar
Li W, Pan D, Chen Y, Li Z, Shen J. [Research progress of the relationship between intestinal flora and type 2 diabetes mellitus] (in Chinese). Chin J Clin Nutr. 2015;23(2):121–124.LiWPanDChenYLiZShenJ[Research progress of the relationship between intestinal flora and type 2 diabetes mellitus] (in Chinese)2015232121124Search in Google Scholar
Li X, Wang N, Yin B, Fang D, Zhao J, Zhang H, Wang G, Chen W.Lactobacillus plantarum X1 with α-glucosidase inhibitory activity ameliorates type 2 diabetes in mice. RSC Adv. 2016;6(68):63536–63547. https://doi.org/10.1039/C6RA10858JLiXWangNYinBFangDZhaoJZhangHWangGChenWLactobacillus plantarum X1 with α-glucosidase inhibitory activity ameliorates type 2 diabetes in mice20166686353663547https://doi.org/10.1039/C6RA10858JSearch in Google Scholar
Lin CF, Lin MY, Lin CN, Chiou MT, Chen JW, Yang KC, Wu MC. Potential probiotic of Lactobacillus strains isolated from the intestinal tracts of pigs and feces of dogs with antibacterial activity against multidrug-resistant pathogenic bacteria. Arch Microbiol. 2020 Sep; 202(7):1849–1860. https://doi.org/10.1007/s00203-020-01908-wLinCFLinMYLinCNChiouMTChenJWYangKCWuMCPotential probiotic of Lactobacillus strains isolated from the intestinal tracts of pigs and feces of dogs with antibacterial activity against multidrug-resistant pathogenic bacteria2020Sep202718491860https://doi.org/10.1007/s00203-020-01908-wSearch in Google Scholar
Liu B, Wang W, Zhu X, Sun X, Xiao J, Li D, Cui Y, Wang C, Shi Y. Response of gut microbiota to dietary fiber and metabolic interaction with SCFAs in piglets. Front Microbiol. 2018 Sep;9:2344. https://doi.org/10.3389/fmicb.2018.02344LiuBWangWZhuXSunXXiaoJLiDCuiYWangCShiYResponse of gut microbiota to dietary fiber and metabolic interaction with SCFAs in piglets2018Sep92344https://doi.org/10.3389/fmicb.2018.02344Search in Google Scholar
Mohseni AH, Casolaro V, Bermúdez-Humarán LG, Keyvani H, Taghinezhad-S S. Modulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response. Gut Microbes. 2021 Jan;13(1):1886844. https://doi.org/10.1080/19490976.2021.1886844MohseniAHCasolaroVBermúdez-HumaránLGKeyvaniHTaghinezhad-SSModulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response2021Jan1311886844https://doi.org/10.1080/19490976.2021.1886844Search in Google Scholar
Nguyen V, Wang SL, Nhan N, Nguyen T, Nguyen N, Nghi D, Cuong N. New records of potent in-vitro antidiabetic properties of Dalbergia tonkinensis heartwood and the bioactivity-guided isolation of active compounds. Molecules. 2018 Jun;23(7):1589. https://doi.org/10.3390/molecules23071589NguyenVWangSLNhanNNguyenTNguyenNNghiDCuongNNew records of potent in-vitro antidiabetic properties of Dalbergia tonkinensis heartwood and the bioactivity-guided isolation of active compounds2018Jun2371589https://doi.org/10.3390/molecules23071589Search in Google Scholar
Noguchi GM, Huising MO. Integrating the inputs that shape pancreatic islet hormone release. Nat Metab. 2019 Dec;1(12):1189–1201. https://doi.org/10.1038/s42255-019-0148-2NoguchiGMHuisingMOIntegrating the inputs that shape pancreatic islet hormone release2019Dec11211891201https://doi.org/10.1038/s42255-019-0148-2Search in Google Scholar
Oh NS, Joung JY, Lee JY, Kim Y. Probiotic and anti-inflammatory potential of Lactobacillus rhamnosus 4B15 and Lactobacillus gasseri 4M13 isolated from infant feces. PLoS One. 2018 Feb; 13(2): e0192021. https://doi.org/10.1371/journal.pone.0192021OhNSJoungJYLeeJYKimYProbiotic and anti-inflammatory potential of Lactobacillus rhamnosus 4B15 and Lactobacillus gasseri 4M13 isolated from infant feces2018Feb132e0192021https://doi.org/10.1371/journal.pone.0192021Search in Google Scholar
Panwar H, Calderwood D, Grant IR, Grover S, Green BD.Lactobacillus strains isolated from infant faeces possess potent inhibitory activity against intestinal alpha- and beta-glucosidases suggesting anti-diabetic potential. Eur J Nutr. 2014 Oct;53(7):1465–1474. https://doi.org/10.1007/s00394-013-0649-9PanwarHCalderwoodDGrantIRGroverSGreenBDLactobacillus strains isolated from infant faeces possess potent inhibitory activity against intestinal alpha- and beta-glucosidases suggesting anti-diabetic potential2014Oct53714651474https://doi.org/10.1007/s00394-013-0649-9Search in Google Scholar
Portincasa P, Bonfrate L, Vacca M, De Angelis M, Farella I, Lanza E, Khalil M, Wang DQH, Sperandio M, Di Ciaula A. Gut microbiota and short chain fatty acids: Implications in glucose homeostasis. Int J Mol Sci. 2022 Jan;23(3):1105. https://doi.org/10.3390/ijms23031105PortincasaPBonfrateLVaccaMDe AngelisMFarellaILanzaEKhalilMWangDQHSperandioMDi CiaulaAGut microbiota and short chain fatty acids: Implications in glucose homeostasis2022Jan2331105https://doi.org/10.3390/ijms23031105Search in Google Scholar
Ramos CL, Thorsen L, Schwan RF, Jespersen L. Strain-specific probiotics properties of Lactobacillus fermentum, Lactobacillus plantarum and Lactobacillus brevis isolates from Brazilian food products. Food Microbiol. 2013 Oct;36(1):22–29. https://doi.org/10.1016/j.fm.2013.03.010RamosCLThorsenLSchwanRFJespersenLStrain-specific probiotics properties of Lactobacillus fermentum, Lactobacillus plantarum and Lactobacillus brevis isolates from Brazilian food products2013Oct3612229https://doi.org/10.1016/j.fm.2013.03.010Search in Google Scholar
Rosas-Ramírez D, Escandón-Rivera S, Pereda-Miranda R. Morning glory resin glycosides as α-glucosidase inhibitors: In vitro and in silico analysis. Phytochemistry. 2018 Apr;148:39–47. https://doi.org/10.1016/j.phytochem.2018.01.012Rosas-RamírezDEscandón-RiveraSPereda-MirandaRMorning glory resin glycosides as α-glucosidase inhibitors: In vitro and in silico analysis2018Apr1483947https://doi.org/10.1016/j.phytochem.2018.01.012Search in Google Scholar
Saleem B, Islam M, Saeed H, Imtiaz F, Asghar M, Saleem Z, Mehmood A, Naheed S. Investigations of Acacia modesta Wall. leaves for in vitro anti-diabetic, proliferative and cytotoxic effects. Braz J Pharm Sci. 2018 Jul;54(2):17467. https://doi.org/10.1590/s2175-97902018000217467SaleemBIslamMSaeedHImtiazFAsgharMSaleemZMehmoodANaheedSInvestigations of Acacia modesta Wall. leaves for in vitro anti-diabetic, proliferative and cytotoxic effects2018Jul54217467https://doi.org/10.1590/s2175-97902018000217467Search in Google Scholar
Salehizadeh M, Modarressi MH, Mousavi SN, Tajabadi Ebrahimi M. Evaluation of lactic acid bacteria isolated from poultry feces as potential probiotic and its in vitro competitive activity against Salmonella typhimurium. Vet Res Forum. 2020 Winter;11(1):67–75. https://doi.org/10.30466/vrf.2018.84395.2110SalehizadehMModarressiMHMousaviSNTajabadi EbrahimiMEvaluation of lactic acid bacteria isolated from poultry feces as potential probiotic and its in vitro competitive activity against Salmonella typhimurium2020Winter1116775https://doi.org/10.30466/vrf.2018.84395.2110Search in Google Scholar
Schloesser A, Esatbeyoglu T, Schultheiß G, Vollert H, Lüersen K, Fischer A, Rimbach G. Antidiabetic properties of an apple/kale extract in vitro, in situ, and in mice fed a western-type diet. J Med Food. 2017 Sep;20(9):846–854. https://doi.org/10.1089/jmf.2017.0019SchloesserAEsatbeyogluTSchultheißGVollertHLüersenKFischerARimbachGAntidiabetic properties of an apple/kale extract in vitro, in situ, and in mice fed a western-type diet2017Sep209846854https://doi.org/10.1089/jmf.2017.0019Search in Google Scholar
Sharma B, Shukla G. Isolation, identification, and characterization of phytase producing probiotic lactic acid bacteria from neonatal fecal samples having dephytinization activity. Food Biotechnol. 2020 Apr;34(2):151–171. https://doi.org/10.1080/08905436.2020.1746332SharmaBShuklaGIsolation, identification, and characterization of phytase producing probiotic lactic acid bacteria from neonatal fecal samples having dephytinization activity2020Apr342151171https://doi.org/10.1080/08905436.2020.1746332Search in Google Scholar
Sun Z, Sun X, Li J, Li Z, Hu Q, Li L, Hao X, Song M, Li C. Using probiotics for type 2 diabetes mellitus intervention: Advances, questions, and potential. Crit Rev Food Sci Nutr. 2020 Feb;60(4):670–683. https://doi.org/10.1080/10408398.2018.1547268SunZSunXLiJLiZHuQLiLHaoXSongMLiCUsing probiotics for type 2 diabetes mellitus intervention: Advances, questions, and potential2020Feb604670683https://doi.org/10.1080/10408398.2018.1547268Search in Google Scholar
Vemuri R, Shinde T, Shastri MD, Perera AP, Tristram S, Martoni CJ, Gundamaraju R, Ahuja KDK, Ball M, Eri R. A human origin strain Lactobacillus acidophilus DDS-1 exhibits superior in vitro probiotic efficacy in comparison to plant or dairy origin probiotics. Int J Med Sci. 2018;15(9):840–848. https://doi.org/10.7150/ijms.25004VemuriRShindeTShastriMDPereraAPTristramSMartoniCJGundamarajuRAhujaKDKBallMEriRA human origin strain Lactobacillus acidophilus DDS-1 exhibits superior in vitro probiotic efficacy in comparison to plant or dairy origin probiotics2018159840848https://doi.org/10.7150/ijms.25004Search in Google Scholar
Wang G, Liu J, Xia Y, Ai L. Probiotics-based interventions for diabetes mellitus: A review. Food Biosci. 2021a Oct;43:101172. https://doi.org/10.1016/j.fbio.2021.101172WangGLiuJXiaYAiLProbiotics-based interventions for diabetes mellitus: A review2021aOct43101172https://doi.org/10.1016/j.fbio.2021.101172Search in Google Scholar
Wang X, Han M, Zhang M, Wang Y, Ren Y, Yue T, Gao Z.In vitro evaluation of the hypoglycemic properties of lactic acid bacteria and its fermentation adaptability in apple juice. LWT. 2021b Jan; 136:110363. https://doi.org/10.1016/j.lwt.2020.110363WangXHanMZhangMWangYRenYYueTGaoZIn vitro evaluation of the hypoglycemic properties of lactic acid bacteria and its fermentation adaptability in apple juice2021bJan136110363https://doi.org/10.1016/j.lwt.2020.110363Search in Google Scholar
Wu Q, Wu S, Cheng Y, Zhang Z, Mao G, Li S, Yang Y, Zhang X, Wu M, Tong H.Sargassum fusiforme fucoidan modifies gut microbiota and intestinal metabolites during alleviation of hyperglycemia in type 2 diabetic mice. Food Funct. 2021 Apr;12(8):3572–3585. https://doi.org/10.1039/D0FO03329DWuQWuSChengYZhangZMaoGLiSYangYZhangXWuMTongHSargassum fusiforme fucoidan modifies gut microbiota and intestinal metabolites during alleviation of hyperglycemia in type 2 diabetic mice2021Apr12835723585https://doi.org/10.1039/D0FO03329DSearch in Google Scholar
Youn HS, Kim JH, Lee JS, Yoon YY, Choi SJ, Lee JY, Kim W, Hwang KW.Lactobacillus plantarum reduces low-grade inflammation and glucose levels in a mouse model of chronic stress and diabetes. Infect Immun. 2021 Jul;89(8):e00615–20. https://doi.org/10.1128/IAI.00615-20YounHSKimJHLeeJSYoonYYChoiSJLeeJYKimWHwangKWLactobacillus plantarum reduces low-grade inflammation and glucose levels in a mouse model of chronic stress and diabetes2021Jul898e0061520https://doi.org/10.1128/IAI.00615-20Search in Google Scholar
Zendeboodi F, Khorshidian N, Mortazavian AM, da Cruz AG. Probiotic: Conceptualization from a new approach. Curr Opin Food Sci. 2020 Apr;32:103–123. https://doi.org/10.1016/j.cofs.2020.03.009ZendeboodiFKhorshidianNMortazavianAMda CruzAGProbiotic: Conceptualization from a new approach2020Apr32103123https://doi.org/10.1016/j.cofs.2020.03.009Search in Google Scholar
Zeng Z, Yuan Q, Yu R, Zhang J, Ma H, Chen S. Ameliorative effects of probiotic Lactobacillus paracasei NL41 on insulin sensitivity, oxidative stress, and beta-cell function in a type 2 diabetes mellitus rat model. Mol Nutr Food Res. 2019 Nov;63(22):1900457. https://doi.org/10.1002/mnfr.201900457ZengZYuanQYuRZhangJMaHChenSAmeliorative effects of probiotic Lactobacillus paracasei NL41 on insulin sensitivity, oxidative stress, and beta-cell function in a type 2 diabetes mellitus rat model2019Nov63221900457https://doi.org/10.1002/mnfr.201900457Search in Google Scholar
Zepeda-Hernández A, Garcia-Amezquita LE, Requena T, García-Cayuela T. Probiotics, prebiotics, and synbiotics added to dairy products: Uses and applications to manage type 2 diabetes. Food Res Int. 2021 Apr;142:110208. https://doi.org/10.1016/j.foodres.2021.110208Zepeda-HernándezAGarcia-AmezquitaLERequenaTGarcía-CayuelaTProbiotics, prebiotics, and synbiotics added to dairy products: Uses and applications to manage type 2 diabetes2021Apr142110208https://doi.org/10.1016/j.foodres.2021.110208Search in Google Scholar
Zhang L, Chu J, Hao W, Zhang J, Li H, Yang C, Yang J, Chen X, Wang H. Gut microbiota and type 2 diabetes mellitus: Association, mechanism, and translational applications. Mediators Inflamm. 2021 Aug;2021:1–12. https://doi.org/10.1155/2021/5110276ZhangLChuJHaoWZhangJLiHYangCYangJChenXWangHGut microbiota and type 2 diabetes mellitus: Association, mechanism, and translational applications2021Aug2021112https://doi.org/10.1155/2021/5110276Search in Google Scholar
Zhang Y, Bai B, Yan Y, Liang J, Guan X. Bound polyphenols from red quinoa prevailed over free polyphenols in reducing postprandial blood glucose rises by inhibiting alpha-glucosidase activity and starch digestion. Nutrients. 2022 Feb;14(4):728. https://doi.org/10.3390/nu14040728ZhangYBaiBYanYLiangJGuanXBound polyphenols from red quinoa prevailed over free polyphenols in reducing postprandial blood glucose rises by inhibiting alpha-glucosidase activity and starch digestion2022Feb144728https://doi.org/10.3390/nu14040728Search in Google Scholar
Zhao W, Chen L, Zhou H, Deng C, Han Q, Chen Y, Wu Q, Li S. Protective effect of carvacrol on liver injury in type 2 diabetic db/db mice. Mol Med Rep. 2021 Aug;24(5):741. https://doi.org/10.3892/mmr.2021.12381ZhaoWChenLZhouHDengCHanQChenYWuQLiSProtective effect of carvacrol on liver injury in type 2 diabetic db/db mice2021Aug245741https://doi.org/10.3892/mmr.2021.12381Search in Google Scholar
Zhong H, Abdullah, Zhang Y, Zhao M, Zhang J, Zhang H, Xi Y, Cai H, Feng F. Screening of novel potential antidiabetic Lactobacillus plantarum strains based on in vitro and in vivo investigations. LWT. 2021 Mar;139:110526. https://doi.org/10.1016/j.lwt.2020.110526ZhongHAbdullahZhangYZhaoMZhangJZhangHXiYCaiHFengFScreening of novel potential antidiabetic Lactobacillus plantarum strains based on in vitro and in vivo investigations2021Mar139110526https://doi.org/10.1016/j.lwt.2020.110526Search in Google Scholar
Zhu DQ, Liu F, Sun Y, Yang LM, Xin L, Meng XC. Genome-wide identification of small RNAs in Bifidobacterium animalis subsp. lactis KLDS 2.0603 and their regulation role in the adaption to gastrointestinal environment. PLoS One. 2015 Feb;10(2):e0117373. https://doi.org/10.1371/journal.pone.0117373ZhuDQLiuFSunYYangLMXinLMengXCGenome-wide identification of small RNAs in Bifidobacterium animalis subsp. lactis KLDS 2.0603 and their regulation role in the adaption to gastrointestinal environment2015Feb102e0117373https://doi.org/10.1371/journal.pone.0117373Search in Google Scholar