<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Introduction</h3>
<p>The severity of COVID-19 relies on several factors, but the overproduction of pro-inflammatory cytokines remains a central mechanism. The aim of this study was to investigate the predictive utility of interleukin (IL)-6, IL-8, IL-10, IL-12, tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ) measurement in patients with COVID-19.</p>
</sec>
<sec><h3>Material and Methods</h3>
<p>We prospectively enrolled 181 adult patients with COVID-19 admitted to the 1<sup>st</sup> Infectious Disease County Hospital Târgu Mureș from December 2020 to September 2021. Serum cytokine levels were measured and correlated with disease severity, need for oxygen therapy, intensive care unit (ICU) transfer, and outcome.</p>
</sec>
<sec><h3>Results</h3>
<p>We found significantly higher serum levels of IL-6, IL-8, and IL-10 in patients with severe COVID-19 and in those with a fatal outcome. The logistic regression analysis showed a significant predictive value for IL-8 regarding disease severity, and for IL6 and IL-10 regarding ICU transfer and fatal outcome.</p>
</sec>
<sec><h3>Conclusions</h3>
<p>Serum levels of IL-6, IL-8, and IL-10 were significantly increased in patients with COVID-19, but their predictive value regarding disease severity and the need for oxygen therapy was poor. We found IL-6 and IL-10 to have a good predictive performance regarding ICU transfer and fatal outcome.</p>
</sec>
</abstract>

Introduction
The severity of COVID-19 relies on several factors, but the overproduction of pro-inflammatory cytokines remains a central mechanism. The aim of this study was to investigate the predictive utility of interleukin (IL)-6, IL-8, IL-10, IL-12, tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ) measurement in patients with COVID-19.

Material and Methods
We prospectively enrolled 181 adult patients with COVID-19 admitted to the 1st Infectious Disease County Hospital Târgu Mureș from December 2020 to September 2021. Serum cytokine levels were measured and correlated with disease severity, need for oxygen therapy, intensive care unit (ICU) transfer, and outcome.

Results
We found significantly higher serum levels of IL-6, IL-8, and IL-10 in patients with severe COVID-19 and in those with a fatal outcome. The logistic regression analysis showed a significant predictive value for IL-8 regarding disease severity, and for IL6 and IL-10 regarding ICU transfer and fatal outcome.

Conclusions
Serum levels of IL-6, IL-8, and IL-10 were significantly increased in patients with COVID-19, but their predictive value regarding disease severity and the need for oxygen therapy was poor. We found IL-6 and IL-10 to have a good predictive performance regarding ICU transfer and fatal outcome.

The Prognostic Utility of Cytokines in Hospitalized COVID-19 Patients

Doctoral School of Medicine and Pharmacy, I.O.S.U.D.

George Emil Palade University of Medicine

First Infectious Disease Clinic of Targu Mureș

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

{"article-title":"The Prognostic Utility of Cytokines in Hospitalized COVID-19 Patients"}

Introduction
The severity of COVID-19 relies on several factors, but the overproduction of pro-inflammatory cytokines remains a central mechanism. The aim of...

The Prognostic Utility of Cytokines in Hospitalized COVID-19 Patients

Article Category: Research Article

Publicado en línea: 14 nov 2023

Páginas: 208 - 217

Recibido: 08 jul 2023

Aceptado: 14 sept 2023

DOI: https://doi.org/10.2478/jccm-2023-0025

Palabras clave
cytokines, prognosis, COVID-19

© 2023 Ákos Vince Andrejkovits et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

The Prognostic Utility of Cytokines in Hospitalized COVID-19 Patients

Article Category: Research Article

Publicado en línea: 14 nov 2023

Páginas: 208 - 217

Recibido: 08 jul 2023

Aceptado: 14 sept 2023

DOI: https://doi.org/10.2478/jccm-2023-0025

Palabras clavecytokines, prognosis, COVID-19

© 2023 Ákos Vince Andrejkovits et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Palabras clave
cytokines, prognosis, COVID-19